This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Bcl-X Monoclonal Antibody (2H12), eBioscience
catalog :
14-6994-81
quantity :
50 ug
price :
US 187.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2H12

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
citations: 4
Reference
Jeon B, Kwon C, Lee J, Moon K, Cha J, Park I, et al. Anticancer Activity of Continentalic Acid in B-Cell Lymphoma. Molecules. 2021;26: pubmed publisher
Hashiramoto A, Murata M, Kawazoe T, Yoshida K, Akiyama C, Shiozawa K, et al. Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B. Rheumatology (Oxford). 2011;50:852-61 pubmed publisher
Li C, Cheng Y, Liao P, Kang J. Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control. Neoplasia. 2010;12:150-60 pubmed
Hsu Y, Youle R. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem. 1997;272:13829-34 pubmed
product information
Product Type :
Antibody
Product Name :
Bcl-X Monoclonal Antibody (2H12), eBioscience
Catalog # :
14-6994-81
Quantity :
50 ug
Price :
US 187.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Immunocytochemistry: 5 ug/mL, Western Blot: 1-2 ug/mL
Species :
Human, Mouse, Non-human primate, Rat
Clone :
2H12
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
The protein encoded the BCL-X gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 5 ug/mL, Western Blot: 1-2 ug/mL
Aliases :
anti-apoptosis regulatory protein; anti-apoptotic Bcl-2 gene family member; anti-apoptotic Bcl-xL; anti-apoptotic regulator Bcl-xL; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl 2 like 1; bcl x; Bcl xL; BCL XL/S; Bcl(X)L; bcl-2 L1; BCL2 like 1; BCL2L; Bcl2l1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCL2-like protein 1; BCLX; bcl-x; Bcl-x long protein; BclxL; Bcl-xL; BCL-XL/S; BclXS; bcl-xS; BLC2L; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3; unnamed protein product
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA