RASSF1A Monoclonal Antibody (eB114-10H1), eBioscience | Invitrogen 14-6888-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RASSF1A Monoclonal Antibody (eB114-10H1), eBioscience

catalog :

14-6888-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eB114-10H1

reactivity :

human, mouse

application :

western blot, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 4a	Yang J, Platt L, Maity B, Ahlers K, Luo Z, Lin Z, et al. RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation. Oncotarget. 2016;7:69159-69172 pubmed publisher
	Ghomlaghi M, Theocharous M, Hoang N, Shin S, von Kriegsheim A, O Neill E, et al. Integrative modeling and analysis of signaling crosstalk reveal molecular switches coordinating Yes-associated protein transcriptional activities. iScience. 2024;27:109031 pubmed publisher
	Romano D, Garc xed a Guti xe9 rrez L, Aboud N, Duffy D, Flaherty K, Frederick D, et al. Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma. Life Sci Alliance. 2022;5: pubmed publisher
	Blanchard T, Czinn S, Banerjee V, Sharda N, Bafford A, Mubariz F, et al. Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer. Cancers (Basel). 2019;11: pubmed publisher
	Li W, Yue F, Dai Y, Shi B, Xu G, Jiang X, et al. Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. Cell Death Differ. 2018;: pubmed publisher
	Dubois F, Jean Jacques B, Roberge H, Benard M, Galas L, Schapman D, et al. A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control. Cell Commun Signal. 2018;16:66 pubmed publisher
	Blanchard T, Lapidus R, Banerjee V, Bafford A, Czinn S, Ahmed H, et al. Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation. Cell Physiol Biochem. 2018;48:1259-1273 pubmed publisher
	Xue W, Feng Y, Wang F, Guo Y, Li P, Wang L, et al. Asialoglycoprotein receptor-magnetic dual targeting nanoparticles for delivery of RASSF1A to hepatocellular carcinoma. Sci Rep. 2016;6:22149 pubmed publisher
	Marzese D, Scolyer R, Roque M, Vargas Roig L, Huynh J, Wilmott J, et al. DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations. Neuro Oncol. 2014;16:1499-509 pubmed publisher
	Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed publisher
	Liu R, Zhang X, Zhang K, Li W, Wang W, Luo D, et al. 5-Aza-2''-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene. Int J Ophthalmol. 2014;7:51-6 pubmed publisher
	Mariano F, Rincon D, Gondak R, Jorge R, Lopes M, Altemani A, et al. Carcinoma ex-pleomorphic adenoma of upper lip showing copy number loss of tumor suppressor genes. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:69-74 pubmed publisher
	Park Y, Kim D, Park K, Baek S, Kwon S, Shin S, et al. RASSF1A and ERCC1 expression levels might be predictive of prognosis in advanced, recurrent, and metastatic squamous cell carcinoma of the head and neck treated with docetaxel and cisplatin. Onkologie. 2012;35:673-82 pubmed publisher
	Chang J, Hsu H, Ni H, Chuang C, Hsiung C, Huang T, et al. Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A. PLoS ONE. 2010;5:e12847 pubmed publisher
	Recino A, Sherwood V, Flaxman A, Cooper W, Latif F, Ward A, et al. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Biochem J. 2010;430:207-13 pubmed publisher
	Rother J, Jones D. Molecular markers of tumor progression in melanoma. Curr Genomics. 2009;10:231-9 pubmed publisher
	Palakurthy R, Wajapeyee N, Santra M, Gazin C, Lin L, Gobeil S, et al. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell. 2009;36:219-30 pubmed publisher
	Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, et al. RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol. 2009;19:279-92 pubmed publisher
	Man C, Rosa J, Lee L, Lee V, Chow B, Lo K, et al. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene. 2007;26:3069-80 pubmed
	Reu F, Leaman D, Maitra R, Bae S, Cherkassky L, Fox M, et al. Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res. 2006;66:2785-93 pubmed
	Vos M, Dallol A, Eckfeld K, Allen N, Donninger H, Hesson L, et al. The RASSF1A tumor suppressor activates Bax via MOAP-1. J Biol Chem. 2006;281:4557-63 pubmed
	Whang Y, Kim Y, Kim J, Yoo Y. RASSF1A suppresses the c-Jun-NH2-kinase pathway and inhibits cell cycle progression. Cancer Res. 2005;65:3682-90 pubmed
	Dallol A, Agathanggelou A, Fenton S, Ahmed Choudhury J, Hesson L, Vos M, et al. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Res. 2004;64:4112-6 pubmed
	Ortiz Vega S, Khokhlatchev A, Nedwidek M, Zhang X, Dammann R, Pfeifer G, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002;21:1381-90 pubmed
	Dammann R, Yang G, Pfeifer G. Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res. 2001;61:3105-9 pubmed

product information

Product Type :

Antibody

Product Name :

RASSF1A Monoclonal Antibody (eB114-10H1), eBioscience

Catalog # :

14-6888-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: Assay-Dependent, Western Blot: 1-10 ug/mL

Species :

Human

Clone :

eB114-10H1

Isotype :

IgG1, kappa

Storage :

4 C

Description :

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay-Dependent, Western Blot: 1-10 ug/mL

Aliases :

123F protein; 123F2; AA536941; AU044980; cardiac-specific ras association domain family 1 protein; NORE2A; pancreas-specific ras association domain family 1 protein; protein 123F2; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; Ras association domain family member 1; ras association domain-containing protein 1; Rassf1; Rassf1A; RASSF1A tumor suppressor; Rassf1B; Rassf1C; RDA32; REH3P21; tumor suppressor protein RDA32; wu:fc17f02; WUGSC:H_LUCA12.5; zgc:112224; zgc:92505; zgc:92505 protein

more info or order :

Invitrogen product webpage