IkB zeta Monoclonal Antibody (LK2NAP), eBioscience | Invitrogen 14-6801-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IkB zeta Monoclonal Antibody (LK2NAP), eBioscience

catalog :

14-6801-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

LK2NAP

reactivity :

mouse

application :

western blot

citations: 8

Reference
Cataisson C, Salcedo R, Michalowski A, Klosterman M, Naik S, Li L, et al. T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis. Mol Cancer Res. 2019;: pubmed publisher
Essig K, Kronbeck N, Guimaraes J, Lohs C, Schlundt A, Hoffmann A, et al. Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat Commun. 2018;9:3810 pubmed publisher
Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, et al. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. J Exp Med. 2018;215:2197-2209 pubmed publisher
Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, et al. I?B? is essential for natural killer cell activation in response to IL-12 and IL-18. Proc Natl Acad Sci U S A. 2010;107:17680-5 pubmed publisher
Okamoto K, Iwai Y, Oh Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464:1381-5 pubmed publisher
Seshadri S, Kannan Y, Mitra S, Parker Barnes J, Wewers M. MAIL regulates human monocyte IL-6 production. J Immunol. 2009;183:5358-68 pubmed publisher
RAICES R, Kannan Y, Bellamkonda Athmaram V, Seshadri S, Wang H, Guttridge D, et al. A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS ONE. 2009;4:e6776 pubmed publisher
Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, et al. Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages. Arch Histol Cytol. 2003;66:53-62 pubmed

product information

Product Type :

Antibody

Product Name :

IkB zeta Monoclonal Antibody (LK2NAP), eBioscience

Catalog # :

14-6801-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Western Blot: 1 ug/mL

Species :

Mouse

Clone :

LK2NAP

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1 ug/mL

Aliases :

AA408868; FLJ30225; FLJ34463; Ikappa B-zeta variant 3; ikappaBzeta; I-kappa-B-zeta; IkappaB-zeta; IKBZ; ikB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; Mail; molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKB inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; RGD1310834