This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
c-Myc Monoclonal Antibody (9E10), eBioscience
catalog :
14-6784-80
quantity :
25 ug
price :
US 133.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9.00E+10

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 35
Reference
Zhang C, Lai M, Khandan L, Lee L, Chen Z, Junge H. Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Nat Commun. 2017;8:16050 pubmed publisher
Casamayor Genescà A, Pla A, Oliver Vila I, Pujals Fonts N, Marín Gallén S, Caminal M, et al. Clinical-scale expansion of CD34+ cord blood cells amplifies committed progenitors and rapid scid repopulation cells. N Biotechnol. 2017;35:19-29 pubmed publisher
Khurana T, Newman Lindsay S, Young P, Slater J. The NPC2 protein: A novel dog allergen. Ann Allergy Asthma Immunol. 2016;116:440-446.e2 pubmed publisher
Crawley S, Weck M, Grega Larson N, Shifrin D, Tyska M. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Dev Cell. 2016;36:190-200 pubmed publisher
Hadzic E, Catillon M, Halavatyi A, Medves S, Van Troys M, Moes M, et al. Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption. PLoS ONE. 2015;10:e0140511 pubmed publisher
Calcagno D, Freitas V, Leal M, de Souza C, Demachki S, Montenegro R, et al. MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer. BMC Gastroenterol. 2013;13:141 pubmed publisher
Zhou B, Gibson Corley K, Herndon M, Sun Y, Gustafson Wagner E, Teoh Fitzgerald M, et al. Integrin ?3?1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma. Mol Cancer Res. 2014;12:143-154 pubmed publisher
Lin S, Jiang M, Wang H, Hu C, Hsu M, Hsi E, et al. Human cytomegalovirus UL76 elicits novel aggresome formation via interaction with S5a of the ubiquitin proteasome system. J Virol. 2013;87:11562-78 pubmed publisher
Tseng W, Huang Y, Chiang N, Chou Y, Wu Y, Luo S, et al. Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases. PLoS ONE. 2013;8:e63963 pubmed publisher
Goswami M, Duvic M, Dougherty A, Ni X. Increased Twist expression in advanced stage of mycosis fungoides and Sézary syndrome. J Cutan Pathol. 2012;39:500-7 pubmed publisher
Satpathy S, Shenoy G, Kaw S, Vaidya T, Bal V, Rath S, et al. Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK. J Immunol. 2010;185:6499-507 pubmed publisher
Nice T, Deng W, Coscoy L, Raulet D. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. J Immunol. 2010;185:5369-76 pubmed publisher
Lee J, Yoon S, Kim H, Kim S, Sohn H, Oh S, et al. Direct and indirect antitumor effects by human peripheral blood lymphocytes expressing both chimeric immune receptor and interleukin-2 in ovarian cancer xenograft model. Cancer Gene Ther. 2010;17:742-50 pubmed publisher
Aguado R, Martin Blanco N, Caraballo M, Canelles M. The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division. Blood. 2010;116:1705-14 pubmed publisher
Lu L, Puri M, Horvath C, Sen G. Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J Biol Chem. 2008;283:14269-76 pubmed publisher
Loewen C, Young B, Tavassoli S, Levine T. Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol. 2007;179:467-83 pubmed
Woo S, Kim D, Jun C, Kim Y, Haar E, Lee S, et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. J Biol Chem. 2007;282:25604-12 pubmed
Li B, Samanta A, Song X, Iacono K, Brennan P, Chatila T, et al. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007;19:825-35 pubmed
Brinkmann M, Spooner E, Hoebe K, Beutler B, Ploegh H, Kim Y. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007;177:265-75 pubmed
Boulland M, Marquet J, Molinier Frenkel V, Moller P, Guiter C, Lasoudris F, et al. Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation. Blood. 2007;110:220-7 pubmed
Kim Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, et al. Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells. J Immunol. 2006;176:2790-8 pubmed
Ohnishi H, Kaneko Y, Okazawa H, Miyashita M, Sato R, Hayashi A, et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. J Neurosci. 2005;25:2702-11 pubmed
Sauvonnet N, Dujeancourt A, Dautry Varsat A. Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J Cell Biol. 2005;168:155-63 pubmed
Oliveria S, Gomez L, Dell Acqua M. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003;160:101-12 pubmed
Hoffman B, Amanullah A, Shafarenko M, Liebermann D. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene. 2002;21:3414-21 pubmed
Komada M, Soriano P. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol. 2002;156:337-48 pubmed
Hilpert K, Hansen G, Wessner H, Kuttner G, Welfle K, Seifert M, et al. Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose. Protein Eng. 2001;14:803-6 pubmed
Hillman M, Yang L, Sun S, Duke J, O Neil K, Kochie J, et al. A comprehensive system for protein purification and biochemical analysis based on antibodies to c-myc peptide. Protein Expr Purif. 2001;23:359-68 pubmed
Boxer L, Dang C. Translocations involving c-myc and c-myc function. Oncogene. 2001;20:5595-610 pubmed
Yoon K, Yoon M, Moir R, Khuon S, Flitney F, Goldman R. Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells. J Cell Biol. 2001;153:503-16 pubmed
Kjøller L, Hall A. Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol. 2001;152:1145-57 pubmed
Dang C, Resar L, Emison E, Kim S, Li Q, Prescott J, et al. Function of the c-Myc oncogenic transcription factor. Exp Cell Res. 1999;253:63-77 pubmed
Prendergast G. Mechanisms of apoptosis by c-Myc. Oncogene. 1999;18:2967-87 pubmed
Xie L, Abou Samra A. Epitope tag mapping of the extracellular and cytoplasmic domains of the rat parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology. 1998;139:4563-7 pubmed
Robertson D, Paterson H, Adamson P, Hall A, Monaghan P. Ultrastructural localization of ras-related proteins using epitope-tagged plasmids. J Histochem Cytochem. 1995;43:471-80 pubmed
product information
Product Type :
Antibody
Product Name :
c-Myc Monoclonal Antibody (9E10), eBioscience
Catalog # :
14-6784-80
Quantity :
25 ug
Price :
US 133.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
ChIP Assay: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 ug/mL
Species :
Human
Clone :
9.00E+10
Isotype :
IgG1
Storage :
4 C
Description :
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 ug/mL
Aliases :
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA