p21 (WAF1, Cip1) Polyclonal Antibody, eBioscience | Invitrogen 14-6715-63 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p21 (WAF1, Cip1) Polyclonal Antibody, eBioscience

catalog :

14-6715-63

quantity :

10 ug

price :

US 93.25

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 9

Reference
Di Luccia B, Acampora V, Saggese A, Calabr xf2 V, Vivo M, Angrisano T, et al. Modulation of intestinal epithelial cell proliferation and apoptosis by Lactobacillus gasseri SF1183. Sci Rep. 2022;12:20248 pubmed publisher
Wang L, Wang B, Gasek N, Zhou Y, Cohn R, Martin D, et al. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022;34:75-89.e8 pubmed publisher
Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, et al. Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence. Front Immunol. 2021;12:823935 pubmed publisher
Wang B, Wang L, Gasek N, Zhou Y, Kim T, Guo C, et al. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging. 2021;1:962-973 pubmed publisher
Moreno G xf3 mez Toledano R, S xe1 nchez Esteban S, Cook A, M xed nguez Moratinos M, Ram xed rez Carracedo R, Revent xfa n P, et al. Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium. Biomolecules. 2021;11: pubmed publisher
Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A. Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells. Cells. 2021;10: pubmed publisher
Jia W, Kong L, Kidoya H, Naito H, Muramatsu F, Hayashi Y, et al. Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells. Nat Commun. 2021;12:2118 pubmed publisher
Geisinger J, Stearns T. CRISPR/Cas9 treatment causes extended TP53-dependent cell cycle arrest in human cells. Nucleic Acids Res. 2020;48:9067-9081 pubmed publisher
Sharma N, Holmes Hampton G, Kumar V, Biswas S, Wuddie K, Stone S, et al. Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059. Sci Rep. 2020;10:6825 pubmed publisher

product information

Product Type :

Antibody

Product Name :

p21 (WAF1, Cip1) Polyclonal Antibody, eBioscience

Catalog # :

14-6715-63

Quantity :

10 ug

Price :

US 93.25

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 ug/mL, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:200

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

4 C

Description :

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:200

Aliases :

Activating Fragment 1; CAP20; cdk inhibitor CIP1; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; Cip1); cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21 ; p21Cip1; p21Cip1/Waf1; p21WAF; PIC1; putative cyclin-dependent kinase inhibitor 1A (p21/WAF1/CIP1); SDI1; SLC12A9; UV96; WAF1; Wild type p53 activated fragment 1 (WAF1); wild-type p53-activated fragment 1