Syk Monoclonal Antibody (4D10.1), eBioscience | Invitrogen 14-6696-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Syk Monoclonal Antibody (4D10.1), eBioscience

catalog :

14-6696-82

quantity :

100 ug

price :

US 354.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D10.1

reactivity :

human

application :

western blot, flow cytometry

citations: 7

Reference
Woods E, Zaiatz Bittencourt V, Bannan C, Bergin C, Finlay D, Hoffmann M, et al. Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination. NPJ Vaccines. 2021;6:117 pubmed publisher
Bode K, Bujupi F, Link C, Hein T, Zimmermann S, Peiris D, et al. Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2. Cell Rep. 2019;29:4435-4446.e9 pubmed publisher
Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, et al. GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity. Cancer Res. 2017;77:5664-5675 pubmed publisher
Geahlen R. Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta. 2009;1793:1115-27 pubmed publisher
Luangdilok S, Box C, Patterson L, Court W, Harrington K, Pitkin L, et al. Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck. Cancer Res. 2007;67:7907-16 pubmed
Chu D, van Oers N, Malissen M, Harris J, Elder M, Weiss A. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol. 1999;163:2610-20 pubmed
Chu D, Spits H, Peyron J, Rowley R, Bolen J, Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 1996;15:6251-61 pubmed

product information

Product Type :

Antibody

Product Name :

Syk Monoclonal Antibody (4D10.1), eBioscience

Catalog # :

14-6696-82

Quantity :

100 ug

Price :

US 354.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent, Western Blot: 5 ug/mL

Species :

Human

Clone :

4D10.1

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Western Blot: 5 ug/mL

Aliases :

DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK