CD254 (RANK Ligand) Monoclonal Antibody (MIH24), eBioscience | Invitrogen 14-6619-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD254 (RANK Ligand) Monoclonal Antibody (MIH24), eBioscience

catalog :

14-6619-82

quantity :

100 ug

price :

US 346.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MIH24

The same clone is also sold as:

BioLegend: 347508, 347504, 347511, 347503, 347509, 347507, 347513, 347501

reactivity :

human

application :

flow cytometry

citations: 6

Reference
Breuer J, Schwab N, Schneider Hohendorf T, Marziniak M, Mohan H, Bhatia U, et al. Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol. 2014;75:739-58 pubmed publisher
Buckle C, De Leenheer E, Lawson M, Yong K, Rabin N, Perry M, et al. Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. PLoS ONE. 2012;7:e41127 pubmed publisher
Kim S, Han S, Withers D, Gaspal F, Bae J, Baik S, et al. CD117? CD3? CD56? OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues. Eur J Immunol. 2011;41:1563-72 pubmed publisher
Soderstrom K, Stein E, Colmenero P, Purath U, Müller Ladner U, de Matos C, et al. Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. Proc Natl Acad Sci U S A. 2010;107:13028-33 pubmed publisher
Krejsek J, Kolackova M, Lonsky V, Kudlová M, Mandak J, Kunes P, et al. RANK/RANKL expression is induced by cardiac surgical operation. Acta Medica (Hradec Kralove). 2009;52:149-53 pubmed
Kanamaru F, Iwai H, Ikeda T, Nakajima A, Ishikawa I, Azuma M. Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells. Immunol Lett. 2004;94:239-46 pubmed

product information

Product Type :

Antibody

Product Name :

CD254 (RANK Ligand) Monoclonal Antibody (MIH24), eBioscience

Catalog # :

14-6619-82

Quantity :

100 ug

Price :

US 346.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Flow Cytometry: 1 ug/test

Species :

Human

Clone :

MIH24

Isotype :

IgG2b, kappa

Storage :

4 C

Description :

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: 1 ug/test

Aliases :

CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine