TOX Monoclonal Antibody (TXRX10), eBioscience | Invitrogen 14-6502-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TOX Monoclonal Antibody (TXRX10), eBioscience

catalog :

14-6502-82

quantity :

100 ug

price :

US 303.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

TXRX10

reactivity :

human, mouse

application :

western blot, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:100; fig 2f	Page N, Lemeille S, Vincenti I, Klimek B, Mariotte A, Wagner I, et al. Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling. Nat Commun. 2021;12:1009 pubmed publisher
flow cytometry; mouse; fig s6f	Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
western blot; mouse; loading ...; fig 6j	Khan O, Giles J, McDonald S, Manne S, Ngiow S, Patel K, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature. 2019;: pubmed publisher
flow cytometry; mouse; loading ...; fig 3f	Li J, He Y, Hao J, Ni L, Dong C. High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells. Front Immunol. 2018;9:2981 pubmed publisher
flow cytometry; mouse; loading ...; fig 5d	Harly C, Cam M, Kaye J, Bhandoola A. Development and differentiation of early innate lymphoid progenitors. J Exp Med. 2018;215:249-262 pubmed publisher
	Fan H, Xia S, Xiang J, Li Y, Ross M, Lim S, et al. Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity. Nature. 2023;623:1034-1043 pubmed publisher
	Li P, Zhou D, Chen D, Cheng Y, Chen Y, Lin Z, et al. Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer. J Biomed Sci. 2023;30:47 pubmed publisher
	Duhalde Vega M, Olivera D, Gast xe3 o Davanzo G, Bertullo M, Noya V, Fabiano de Souza G, et al. PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease. Sci Adv. 2022;8:eabn6545 pubmed publisher
	Ma K, Sun L, Shen M, Zhang X, Xiao Z, Wang J, et al. Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion. iScience. 2022;25:104347 pubmed publisher
	Robles Valero J, Fernandez Nevado L, Lorenzo Martín L, Cuadrado M, Fernández Pisonero I, Rodríguez Fdez S, et al. Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis. EMBO J. 2021;40:e108125 pubmed publisher
	Scharping N, Rivadeneira D, Menk A, Vignali P, Ford B, Rittenhouse N, et al. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol. 2021;22:205-215 pubmed publisher
	Zhou M, Sacirbegovic F, Zhao K, Rosenberger S, Shlomchik W. T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect. Nat Commun. 2020;11:4227 pubmed publisher
	Yoshitomi H, Kobayashi S, Miyagawa Hayashino A, Okahata A, Doi K, Nishitani K, et al. Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Nat Commun. 2018;9:3762 pubmed publisher
	Aliahmad P, de la Torre B, Kaye J. Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat Immunol. 2010;11:945-52 pubmed publisher
	Aliahmad P, Kaye J. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008;205:245-56 pubmed publisher
	Aliahmad P, O Flaherty E, Han P, Goularte O, Wilkinson B, Satake M, et al. TOX provides a link between calcineurin activation and CD8 lineage commitment. J Exp Med. 2004;199:1089-99 pubmed
	Wilkinson B, Chen J, Han P, Rufner K, Goularte O, Kaye J. TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat Immunol. 2002;3:272-80 pubmed

product information

Product Type :

Antibody

Product Name :

TOX Monoclonal Antibody (TXRX10), eBioscience

Catalog # :

14-6502-82

Quantity :

100 ug

Price :

US 303.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Immunoprecipitation: Assay-Dependent, Western Blot: 5 ug/mL

Species :

Human, Mouse

Clone :

TXRX10

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay-Dependent, Western Blot: 5 ug/mL

Aliases :

1700007F02Rik; KIAA0808; thymocyte selection associated high mobility group box; thymocyte selection-associated high mobility group box; thymocyte selection-associated high mobility group box protein TOX; thymocyte selection-associated HMG box; thymus high mobility group box protein TOX; TOX; TOX1

more info or order :

Invitrogen product webpage