TOX Monoclonal Antibody (TXRX10), eBioscience | Invitrogen 14-6502-37 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TOX Monoclonal Antibody (TXRX10), eBioscience

catalog :

14-6502-37

quantity :

2 mg

price :

US 1388.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

TXRX10

reactivity :

human, mouse

application :

western blot, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:100; fig 2f	Page N, Lemeille S, Vincenti I, Klimek B, Mariotte A, Wagner I, et al. Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling. Nat Commun. 2021;12:1009 pubmed publisher
flow cytometry; mouse; fig s6f	Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
	Ma K, Sun L, Shen M, Zhang X, Xiao Z, Wang J, et al. Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion. iScience. 2022;25:104347 pubmed publisher
	Robles Valero J, Fernandez Nevado L, Lorenzo Martín L, Cuadrado M, Fernández Pisonero I, Rodríguez Fdez S, et al. Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis. EMBO J. 2021;40:e108125 pubmed publisher
	Zhou M, Sacirbegovic F, Zhao K, Rosenberger S, Shlomchik W. T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect. Nat Commun. 2020;11:4227 pubmed publisher
	Aliahmad P, Kaye J. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008;205:245-56 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TOX Monoclonal Antibody (TXRX10), eBioscience

Catalog # :

14-6502-37

Quantity :

2 mg

Price :

US 1388.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Immunoprecipitation: Assay-Dependent, Western Blot: 5 µg/mL

Species :

Human, Mouse

Clone :

TXRX10

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay-Dependent, Western Blot: 5 µg/mL

Aliases :

1700007F02Rik; KIAA0808; thymocyte selection associated high mobility group box; thymocyte selection-associated high mobility group box; thymocyte selection-associated high mobility group box protein TOX; thymocyte selection-associated HMG box; thymus high mobility group box protein TOX; TOX; TOX1

more info or order :

Invitrogen product webpage