VEGF Receptor 3 Monoclonal Antibody (AFL4), eBioscience | Invitrogen 14-5988-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VEGF Receptor 3 Monoclonal Antibody (AFL4), eBioscience

catalog :

14-5988-81

quantity :

50 µg

price :

US 99.50

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

AFL4

reactivity :

mouse

application :

western blot, immunohistochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 35

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; loading ...; fig 4b	Sato T, Paquet Fifield S, Harris N, Roufail S, Turner D, Yuan Y, et al. VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury. J Pathol. 2016;239:152-61 pubmed publisher
immunohistochemistry; mouse	Dellinger M, Meadows S, Wynne K, Cleaver O, Brekken R. Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS ONE. 2013;8:e74686 pubmed publisher
	Cioffi S, Flore G, Martucciello S, Bilio M, Turturo M, Illingworth E. VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome. Life Sci Alliance. 2022;5: pubmed publisher
	Mece O, Houbaert D, Sassano M, Durré T, Maes H, Schaaf M, et al. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis. Nat Commun. 2022;13:2760 pubmed publisher
	Wang X, Yang L, Wang Y, Xu Z, Feng Y, Zhang J, et al. Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level. Cell Res. 2020;30:1109-1126 pubmed publisher
	Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, et al. G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling. Cell Rep. 2016;17:2532-2541 pubmed publisher
	Tagaram H, Desai D, Li G, Liu D, Rountree C, Gowda K, et al. A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. Pharmaceuticals (Basel). 2016;9: pubmed publisher
	Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
	Iwami D, Brinkman C, Bromberg J. Vascular endothelial growth factor c/vascular endothelial growth factor receptor 3 signaling regulates chemokine gradients and lymphocyte migration from tissues to lymphatics. Transplantation. 2015;99:668-77 pubmed publisher
	Nakayama A, Nakayama M, Turner C, Höing S, Lepore J, Adams R. Ephrin-B2 controls PDGFR? internalization and signaling. Genes Dev. 2013;27:2576-89 pubmed publisher
	Thiele W, Rothley M, Teller N, Jung N, Bulat B, Plaumann D, et al. Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis. 2013;34:2804-13 pubmed publisher
	Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams R. Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS ONE. 2012;7:e41116 pubmed publisher
	Jayaraman P, Parikh F, López Rivera E, Hailemichael Y, Clark A, Ma G, et al. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol. 2012;188:5365-76 pubmed publisher
	Lapinski P, Kwon S, Lubeck B, Wilkinson J, Srinivasan R, Sevick Muraca E, et al. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 2012;122:733-47 pubmed publisher
	Cesca F, Yabe A, Spencer Dene B, Scholz Starke J, Medrihan L, Maden C, et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012;19:194-208 pubmed publisher
	Tvorogov D, Anisimov A, Zheng W, Leppänen V, Tammela T, Laurinavicius S, et al. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 2010;18:630-40 pubmed publisher
	Zhang L, Zhou F, Han W, Shen B, Luo J, Shibuya M, et al. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010;20:1319-31 pubmed publisher
	Kim H, Nguyen V, Petrova T, Cruz M, Alitalo K, Dumont D. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol. 2010;10:72 pubmed publisher
	Garmy Susini B, Avraamides C, Schmid M, Foubert P, Ellies L, Barnes L, et al. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010;70:3042-51 pubmed publisher
	Teller N, Thiele W, Boettler U, Sleeman J, Marko D. Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol Nutr Food Res. 2009;53:1075-83 pubmed publisher
	Taniguchi K, Ishizaki T, Ayada T, Sugiyama Y, Wakabayashi Y, Sekiya T, et al. Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. Cancer Sci. 2009;100:1648-54 pubmed publisher
	Teller N, Thiele W, Marczylo T, Gescher A, Boettler U, Sleeman J, et al. Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. J Agric Food Chem. 2009;57:3094-101 pubmed publisher
	Vondenhoff M, van de Pavert S, Dillard M, Greuter M, Goverse G, Oliver G, et al. Lymph sacs are not required for the initiation of lymph node formation. Development. 2009;136:29-34 pubmed publisher
	Yamaguchi T, Ichise T, Iwata O, Hori A, Adachi T, Nakamura M, et al. Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J. 2008;275:1988-98 pubmed publisher
	Copland I, Sharma K, Lejeune L, Eliopoulos N, Stewart D, Liu P, et al. CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization. Exp Hematol. 2008;36:93-103 pubmed
	Garmy Susini B, Makale M, Fuster M, Varner J. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007;426:415-38 pubmed
	Kanehira M, Xin H, Hoshino K, Maemondo M, Mizuguchi H, Hayakawa T, et al. Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells. Cancer Gene Ther. 2007;14:894-903 pubmed
	Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, et al. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007;27:4541-50 pubmed
	Galvagni F, Anselmi F, Salameh A, Orlandini M, Rocchigiani M, Oliviero S. Vascular endothelial growth factor receptor-3 activity is modulated by its association with caveolin-1 on endothelial membrane. Biochemistry. 2007;46:3998-4005 pubmed
	Orlandini M, Spreafico A, Bardelli M, Rocchigiani M, Salameh A, Nucciotti S, et al. Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation. J Biol Chem. 2006;281:17961-7 pubmed
	Colucci S, Taraboletti G, Primo L, Viale A, Roca C, Valdembri D, et al. Gorham-Stout syndrome: a monocyte-mediated cytokine propelled disease. J Bone Miner Res. 2006;21:207-18 pubmed
	Kubo H, Fujiwara T, Jussila L, Hashi H, Ogawa M, Shimizu K, et al. Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood. 2000;96:546-53 pubmed
	Saaristo A, Partanen T, Arola J, Jussila L, Hytonen M, Makitie A, et al. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. Am J Pathol. 2000;157:7-14 pubmed
	Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol. 2000;156:1499-504 pubmed
	Larrivee B, Karsan A. Signaling pathways induced by vascular endothelial growth factor (review). Int J Mol Med. 2000;5:447-56 pubmed

product information

Product Type :

Antibody

Product Name :

VEGF Receptor 3 Monoclonal Antibody (AFL4), eBioscience

Catalog # :

14-5988-81

Quantity :

50 µg

Price :

US 99.50

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-Dependent, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent

Species :

Mouse

Clone :

AFL4

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Format :

Liquid

Applications w/Dilutions :

Aliases :

AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3

more info or order :

Invitrogen product webpage