MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), eBioscience | Invitrogen 14-5980-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), eBioscience

catalog :

14-5980-81

quantity :

50 µg

price :

US 78.25

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14-4-4S

reactivity :

mouse, rat

application :

flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s2a	Wang X, Chen H, Tian R, Zhang Y, Drutskaya M, Wang C, et al. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nat Commun. 2017;8:14091 pubmed publisher
	Quixabeira D, Zafar S, Santos J, Cervera Carrascon V, Havunen R, Kudling T, et al. Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control. Front Immunol. 2021;12:674400 pubmed publisher
	Krishnan B, Massilamany C, Basavalingappa R, Gangaplara A, Rajasekaran R, Afzal M, et al. Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice. J Immunol. 2018;200:523-537 pubmed publisher
	Carrillo E, Jimenez M, Sanchez C, Cunha J, Martins C, da Paixão Sevá A, et al. Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis. PLoS ONE. 2014;9:e89412 pubmed publisher
	Lewkowich I, Lajoie S, Stoffers S, Suzuki Y, Richgels P, Dienger K, et al. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunol. 2013;6:728-39 pubmed publisher
	Farquhar C, Paterson A, Cobbold S, Garcia Rueda H, Fairchild P, Yates S, et al. Tolerogenicity is not an absolute property of a dendritic cell. Eur J Immunol. 2010;40:1728-37 pubmed publisher
	Liu J, Ruckwardt T, Chen M, Johnson T, Graham B. Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model. J Virol. 2009;83:4934-41 pubmed publisher
	Turnquist H, Sumpter T, Tsung A, Zahorchak A, Nakao A, Nau G, et al. IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol. 2008;181:62-72 pubmed
	Robbins C, Franco F, Mouded M, Cernadas M, Shapiro S. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol. 2008;180:6623-8 pubmed
	Tseng S, Liu M, Dustin M. CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol. 2005;175:7829-36 pubmed
	Augello A, Tasso R, Negrini S, Amateis A, Indiveri F, Cancedda R, et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol. 2005;35:1482-90 pubmed
	Farr A, DeRoos P, Eastman S, Rudensky A. Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells. Eur J Immunol. 1996;26:3185-93 pubmed
	Pruitt S, Baldwin W, Barth R, Sanfilippo F. The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. Transplantation. 1993;56:1318-24 pubmed
	Spencer J, Freed J, Kubo R. Expression and function of mixed isotype MHC class II molecules in normal mice. J Immunol. 1993;151:6822-32 pubmed
	Maloy W, Ozato K, Sachs D, Coligan J. Evidence for the association of I-A and I-E molecules in d-haplotype mice. Mol Immunol. 1986;23:263-9 pubmed
	Liu H, Steiner B, Alder J, Baertschy D, Schell R. Immune T cells sorted by flow cytometry confer protection against infection with Treponema pallidum subsp. pertenue in hamsters. Infect Immun. 1990;58:1685-90 pubmed

product information

Product Type :

Antibody

Product Name :

MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), eBioscience

Catalog # :

14-5980-81

Quantity :

50 µg

Price :

US 78.25

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse, Rat

Clone :

14-4-4S

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

AI323765; cell surface glycoprotein; E-alpha-f; H-2 class II histocompatibility antigen, E-D alpha chain; H-2 class II histocompatibility antigen, E-K alpha chain; H-2 class II histocompatibility antigen, E-U alpha chain; H-2 class II histocompatibility antigen, I-E beta chain; H-2Ea; H2-Ea; H2-Ea-ps; H2Eb; H-2Eb; H2-Eb1; H2-IE-alpha; histocompatibility 2, class II antigen E alpha; histocompatibility 2, class II antigen E alpha, pseudogene; histocompatibility 2, class II antigen E beta; Ia3; Ia-3; Ia4; Ia-4; I-E alpha MHC class II; I-E beta MHC class II; I-Ealpha; major histocompatibility complex H-2E beta chain; MGC117888; MHC class II antigen E alpha; MHC class II IE-b; MHC class II protein; MHC H2-IE-beta cell surface glycoprotein

more info or order :

Invitrogen product webpage