This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Nur77 Monoclonal Antibody (12.14), eBioscience™
catalog :
14-5965-95
quantity :
10 mg
price :
US 3000.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
12.14
reactivity :
mouse
application :
western blot
citations: 7
Reference
Oh J, Wang W, Thomas R, Su D. Capacity of tTreg generation is not impaired in the atrophied thymus. PLoS Biol. 2017;15:e2003352 pubmed publisher
Orta Mascaró M, Consuegra Fernández M, Carreras E, Roncagalli R, Carreras Sureda A, Alvarez P, et al. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016;213:1387-97 pubmed publisher
Bremser A, Brack M, Izcue A. Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction. PLoS ONE. 2015;10:e0137393 pubmed publisher
Kirchenbaum G, St Clair J, Detanico T, Aviszus K, Wysocki L. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol. 2014;44:970-82 pubmed publisher
Schmidt A, Zou T, Joshi R, Leichner T, Pimentel M, Sommers C, et al. Diacylglycerol kinase ? limits the generation of natural regulatory T cells. Sci Signal. 2013;6:ra101 pubmed publisher
Hawk J, Bookout A, Poplawski S, Bridi M, Rao A, Sulewski M, et al. NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest. 2012;122:3593-602 pubmed publisher
Hwang S, Song K, Lesourne R, Lee J, Pinkhasov J, Li L, et al. Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med. 2012;209:1781-95 pubmed
product information
Product Type :
Antibody
Product Name :
Nur77 Monoclonal Antibody (12.14), eBioscience™
Catalog # :
14-5965-95
Quantity :
10 mg
Price :
US 3000.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Western Blot: 5 µg/mL
Species :
Mouse
Clone :
12.14
Isotype :
IgG1, kappa
Storage :
4° C
Description :
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 5 µg/mL
Aliases :
early response protein NAK1; Gfrp; GFRP1; growth factor-inducible nuclear protein N10; Hbr1; Hbr-1; Hmr; hormone receptor; immediate early gene transcription factor NGFI-B; MGC9485; N10; NAK1; NAK-1; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; NGFIB; NGFI-B; NP10; Nr4a1; nuclear hormone receptor NUR/77; Nuclear protein N10; nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; NUR77; Orphan nuclear receptor HMR; orphan nuclear receptor TR3; Orphan receptor tr3; ST-59; steroid receptor TR3; testicular receptor 3; TIS1; TR3; TR3 orphan receptor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA