Blimp-1 Monoclonal Antibody (6D3), eBioscience | Invitrogen 14-5963-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Blimp-1 Monoclonal Antibody (6D3), eBioscience

catalog :

14-5963-82

quantity :

100 µg

price :

US 420.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

6D3

reactivity :

human, mouse, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; 1:50; fig 3g immunohistochemistry - paraffin section; pigs ; 1:50; loading ...; fig 1a	Kobayashi T, Zhang H, Tang W, Irie N, Withey S, Klisch D, et al. Principles of early human development and germ cell program from conserved model systems. Nature. 2017;546:416-420 pubmed publisher
western blot; mouse; loading ...; fig 3g	Vaidyanathan B, Chaudhry A, Yewdell W, Angeletti D, Yen W, Wheatley A, et al. The aryl hydrocarbon receptor controls cell-fate decisions in B cells. J Exp Med. 2017;214:197-208 pubmed publisher
immunohistochemistry; mouse; 1:50	Murakami K, GÃ¼nesdogan U, Zylicz J, Tang W, Sengupta R, Kobayashi T, et al. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature. 2016;529:403-407 pubmed publisher
immunohistochemistry - paraffin section; human; fig 7	Mould A, Morgan M, Nelson A, Bikoff E, Robertson E. Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation. PLoS Genet. 2015;11:e1005375 pubmed publisher
western blot; mouse; fig 10B	Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher
immunohistochemistry - paraffin section; mouse	Geula S, Moshitch Moshkovitz S, Dominissini D, Mansour A, Kol N, Salmon Divon M, et al. Stem cells. m6A mRNA methylation facilitates resolution of naÃ¯ve pluripotency toward differentiation. Science. 2015;347:1002-6 pubmed publisher
immunohistochemistry - frozen section; human; 1:100; fig 4a immunocytochemistry; human; 1:100; fig 2e western blot; human; fig 5a	Irie N, Weinberger L, Tang W, Kobayashi T, Viukov S, Manor Y, et al. SOX17 is a critical specifier of human primordial germ cell fate. Cell. 2015;160:253-68 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 1	Kretzschmar K, Cottle D, Donati G, Chiang M, Quist S, Gollnick H, et al. BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions. Stem Cell Reports. 2014;3:620-33 pubmed publisher
	Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, et al. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation. Dis Model Mech. 2021;14: pubmed publisher
	Oulès B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba A, et al. Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Nat Commun. 2020;11:5067 pubmed publisher
	Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen L, Han R, et al. MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity. J Clin Invest. 2020;130:6242-6260 pubmed publisher
	Ge W, Tan S, Wang S, Li L, Sun X, Shen W, et al. Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development. Theranostics. 2020;10:7581-7598 pubmed publisher
	Wang X, Liao T, Wan C, Yang X, Zhao J, Fu R, et al. Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale. Peerj. 2019;6:e6143 pubmed publisher
	White C, Pone E, Lam T, Tat C, Hayama K, Li G, et al. Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses. J Immunol. 2014;193:5933-50 pubmed publisher
	Park K, Bayles I, Szlachta McGinn A, Paul J, Boiko J, Santos P, et al. Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol. 2014;193:4663-74 pubmed publisher
	Driskell R, Lichtenberger B, Hoste E, Kretzschmar K, Simons B, Charalambous M, et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013;504:277-281 pubmed publisher
	Hu G, Chen J. A genome-wide regulatory network identifies key transcription factors for memory CD8? T-cell development. Nat Commun. 2013;4:2830 pubmed publisher
	Lesko M, Driskell R, Kretzschmar K, Goldie S, Watt F. Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013;382:15-26 pubmed publisher
	Grabole N, Tischler J, Hackett J, Kim S, Tang F, Leitch H, et al. Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep. 2013;14:629-37 pubmed publisher
	Kallies A, Xin A, Belz G, Nutt S. Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity. 2009;31:283-95 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Blimp-1 Monoclonal Antibody (6D3), eBioscience

Catalog # :

14-5963-82

Quantity :

100 µg

Price :

US 420.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: (0.5 µg)/test), Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 1-10 µg/mL

Species :

Human, Mouse

Clone :

6D3

Isotype :

IgG2a

Storage :

4° C

Description :

Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: (0.5 µg)/test), Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 1-10 µg/mL

Aliases :

B lymphocyte-induced maturation protein 1; b2b1765Clo; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; Blimp1; BLIMP-1; B-lymphocyte-induced maturation protein 1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR/SET domain 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; Prdm1; RP1-134E15.1; ZNFPR1A1

more info or order :

Invitrogen product webpage