This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR beta Monoclonal Antibody (H57-597), eBioscience™
catalog :
14-5961-81
quantity :
50 µg
price :
US 309.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
H57-597
reactivity :
mouse
application :
immunohistochemistry, flow cytometry
citations: 81
Reference
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
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Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Robles Valero J, Lorenzo Martín L, Menacho Márquez M, Fernández Pisonero I, Abad A, Camos M, et al. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2017;32:608-623.e9 pubmed publisher
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed publisher
Etzensperger R, Kadakia T, Tai X, Alag A, Guinter T, Egawa T, et al. Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus. Nat Immunol. 2017;18:1218-1227 pubmed publisher
Shan Q, Zeng Z, Xing S, Li F, Hartwig S, Gullicksrud J, et al. The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017;18:931-939 pubmed publisher
Dai K, Huang L, Huang Y, Chen Z, Yang L, Jiang Y. 1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model. Front Immunol. 2017;8:320 pubmed publisher
Lee B, Ko E, Lee J, Jo Y, Hwang H, Goh T, et al. Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice. Int J Chron Obstruct Pulmon Dis. 2017;12:817-827 pubmed publisher
Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol. 2017;8:94 pubmed publisher
Vasanthakumar A, Xu D, Lun A, Kueh A, van Gisbergen K, Iannarella N, et al. A non-canonical function of Ezh2 preserves immune homeostasis. EMBO Rep. 2017;18:619-631 pubmed publisher
Alkayyal A, Tai L, Kennedy M, de Souza C, Zhang J, Lefebvre C, et al. NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine. Cancer Immunol Res. 2017;5:211-221 pubmed publisher
Nowyhed H, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, et al. ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content. Sci Rep. 2017;7:40273 pubmed publisher
Cruz A, Ramaswamy M, Ouyang C, Klebanoff C, Sengupta P, Yamamoto T, et al. Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction. Nat Commun. 2016;7:13895 pubmed publisher
Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, et al. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016;7:12756 pubmed publisher
Proekt I, Miller C, Jeanne M, Fasano K, Moon J, Lowell C, et al. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016;126:3758-3771 pubmed publisher
Lebrero Fernández C, Bas Forsberg A. The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine. Sci Rep. 2016;6:31524 pubmed publisher
Huang B, Gomez Rodriguez J, Preite S, Garrett L, Harper U, Schwartzberg P. CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development. PLoS ONE. 2016;11:e0156072 pubmed publisher
Xing S, Li F, Zeng Z, Zhao Y, Yu S, Shan Q, et al. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016;17:695-703 pubmed publisher
Xiao R, Bergin S, Huang W, Slater A, Liu X, Judd R, et al. Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype. Cancer Immunol Res. 2016;4:488-497 pubmed publisher
Wu L, Li N, Zhang M, Xue S, Cassady K, Lin Q, et al. MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci U S A. 2015;112:15994-9 pubmed publisher
Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, et al. DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS Genet. 2015;11:e1005645 pubmed publisher
Alam M, Gaida M, Bergmann F, Lasitschka F, Giese T, Giese N, et al. Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med. 2015;21:1337-43 pubmed publisher
Galipeau H, McCarville J, Huebener S, Litwin O, Meisel M, Jabri B, et al. Intestinal microbiota modulates gluten-induced immunopathology in humanized mice. Am J Pathol. 2015;185:2969-82 pubmed publisher
Zanvit P, Konkel J, Jiao X, Kasagi S, Zhang D, Wu R, et al. Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nat Commun. 2015;6:8424 pubmed publisher
Klemann C, Schröder A, Dreier A, Möhn N, Dippel S, Winterberg T, et al. Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients. Gastroenterology. 2016;150:229-241.e5 pubmed publisher
Arnold I, Mathisen S, Schulthess J, Danne C, Hegazy A, Powrie F. CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. Mucosal Immunol. 2016;9:352-63 pubmed publisher
Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, et al. Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2016;27:92-106 pubmed publisher
Borthwick L, Barron L, Hart K, Vannella K, Thompson R, Oland S, et al. Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis. Mucosal Immunol. 2016;9:38-55 pubmed publisher
Martinet L, Ferrari de Andrade L, Guillerey C, Lee J, Liu J, Souza Fonseca Guimaraes F, et al. DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 2015;11:85-97 pubmed publisher
Van Praet J, Donovan E, Vanassche I, Drennan M, Windels F, Dendooven A, et al. Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015;34:466-74 pubmed publisher
Yumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, et al. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest. 2015;125:621-35 pubmed publisher
Saunders A, Shim Y, Johnson P. Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation. J Immunol. 2014;193:2831-42 pubmed publisher
Cao Q, Wang Y, Wang X, Lu J, Lee V, Ye Q, et al. Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy. J Am Soc Nephrol. 2015;26:349-63 pubmed publisher
Diana J, Lehuen A. Macrophages and ?-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes. EMBO Mol Med. 2014;6:1090-104 pubmed publisher
Zvezdova E, Lee J, El Khoury D, Barr V, Akpan I, Samelson L, et al. In vivo functional mapping of the conserved protein domains within murine Themis1. Immunol Cell Biol. 2014;92:721-8 pubmed publisher
Kaczmarek J, Homsi Y, van Üüm J, Metzger C, Knolle P, Kolanus W, et al. Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time. PLoS ONE. 2014;9:e99574 pubmed publisher
Nandagopal N, Ali A, Komal A, Lee S. The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions. Front Immunol. 2014;5:187 pubmed publisher
White A, Jenkinson W, Cowan J, Parnell S, Bacon A, Jones N, et al. An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells. J Immunol. 2014;192:2659-66 pubmed publisher
Duarte J, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS ONE. 2013;8:e79819 pubmed publisher
Kansara M, Leong H, Lin D, Popkiss S, Pang P, Garsed D, et al. Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation. J Clin Invest. 2013;123:5351-60 pubmed publisher
Stoppelenburg A, Salimi V, Hennus M, Plantinga M, Huis in t Veld R, Walk J, et al. Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS ONE. 2013;8:e78461 pubmed publisher
Hong C, Nam A, Keller H, Ligons D, Park J, Yoon H, et al. Interleukin-6 expands homeostatic space for peripheral T cells. Cytokine. 2013;64:532-40 pubmed publisher
Saligrama N, Case L, del Rio R, Noubade R, Teuscher C. Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. J Immunol. 2013;191:614-22 pubmed publisher
Yang Q, Monticelli L, Saenz S, Chi A, Sonnenberg G, Tang J, et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013;38:694-704 pubmed publisher
Reis B, Rogoz A, Costa Pinto F, Taniuchi I, Mucida D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4? T cell immunity. Nat Immunol. 2013;14:271-80 pubmed publisher
Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel Wahab O, et al. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 2013;210:339-53 pubmed publisher
Chen X, Wu X, Zhou Q, Howard O, Netea M, Oppenheim J. TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol. 2013;190:1076-84 pubmed publisher
van Helden M, Zaiss D, Sijts A. CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS ONE. 2012;7:e52027 pubmed publisher
Saligrama N, Noubade R, Case L, del Rio R, Teuscher C. Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system. Eur J Immunol. 2012;42:1536-46 pubmed publisher
Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, et al. PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ. 2012;19:1722-32 pubmed publisher
Berent Maoz B, Montecino Rodriguez E, Signer R, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012;119:5715-21 pubmed publisher
Blankenhorn E, Butterfield R, Case L, Wall E, del Rio R, DIEHL S, et al. Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. Ann Neurol. 2011;70:887-96 pubmed publisher
Bunnell T, Burbach B, Shimizu Y, Ervasti J. ?-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011;22:4047-58 pubmed publisher
Lee I, van den Elzen P, Tan R, Priatel J. NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes. J Immunol. 2011;187:2898-904 pubmed publisher
Zlotoff D, Zhang S, De Obaldia M, Hess P, Todd S, Logan T, et al. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011;118:1962-70 pubmed publisher
Haas J, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, et al. Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in ?? and ?? T cells. PLoS ONE. 2011;6:e20171 pubmed publisher
Hall J, Cannons J, Grainger J, Dos Santos L, Hand T, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34:435-47 pubmed publisher
Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog. 2011;7:e1001274 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Sabatino J, Huang J, Zhu C, Evavold B. High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses. J Exp Med. 2011;208:81-90 pubmed publisher
Cheng C, Duwaerts C, Rooijen N, Wintermeyer P, Mott S, Gregory S. NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism. J Hepatol. 2011;54:746-52 pubmed publisher
Ishikawa E, Miyake Y, Hara H, Saito T, Yamasaki S. Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation. Proc Natl Acad Sci U S A. 2010;107:19979-84 pubmed publisher
McCarl C, Khalil S, Ma J, Oh Hora M, Yamashita M, Roether J, et al. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185:5845-58 pubmed publisher
Liu H, Chi A, Arnett K, Chiang M, Xu L, Shestova O, et al. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010;24:2395-407 pubmed publisher
Zhu Y, Ju S, Chen E, Dai S, Li C, MOREL P, et al. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. 2010;185:3174-83 pubmed publisher
Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, et al. A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010;160:292-310 pubmed publisher
Wilson D, Grotenbreg G, Liu K, Zhao Y, Frickel E, Gubbels M, et al. Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathog. 2010;6:e1000815 pubmed publisher
Tan A, Lam K. Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J Immunol. 2010;184:1849-57 pubmed publisher
Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, et al. Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood. 2010;115:995-1005 pubmed publisher
Armstrong A, Gebre A, Parks J, Hedrick C. ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol. 2010;184:173-83 pubmed publisher
Kohu K, Ohmori H, Wong W, Onda D, Wakoh T, Kon S, et al. The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J Immunol. 2009;183:7817-24 pubmed publisher
Banh C, Fugere C, Brossay L. Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood. 2009;114:5299-306 pubmed publisher
Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, et al. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009;185:291-303 pubmed publisher
Mix H, Weiler Normann C, Thimme R, Ahlenstiel G, Shin E, Herkel J, et al. Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. Gastroenterology. 2008;135:2107-18 pubmed publisher
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007;204:57-63 pubmed
Coles M, Veiga Fernandes H, Foster K, Norton T, Pagakis S, Seddon B, et al. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A. 2006;103:13457-62 pubmed
product information
Product Type :
Antibody
Product Name :
TCR beta Monoclonal Antibody (H57-597), eBioscience™
Catalog # :
14-5961-81
Quantity :
50 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent
Species :
Mouse
Clone :
H57-597
Isotype :
IgG
Storage :
4° C
Description :
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent
Aliases :
bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA