AID Monoclonal Antibody (mAID-2), eBioscience | Invitrogen 14-5959-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AID Monoclonal Antibody (mAID-2), eBioscience

catalog :

14-5959-80

quantity :

25 µg

price :

US 169.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

mAID-2

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2b	Kalchschmidt J, Bashford Rogers R, Paschos K, Gillman A, Styles C, Kellam P, et al. Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells. J Exp Med. 2016;213:921-8 pubmed publisher
flow cytometry; mouse; loading ...; fig 1c	Jackson S, Jacobs H, Arkatkar T, Dam E, Scharping N, Kolhatkar N, et al. B cell IFN-Î³ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016;213:733-50 pubmed publisher
western blot; mouse; fig S2	Yousif A, Stanlie A, Mondal S, Honjo T, Begum N. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. Proc Natl Acad Sci U S A. 2014;111:E1016-24 pubmed publisher
immunohistochemistry - frozen section; mouse	Wang J, New J, Xie S, Yang P, Wu Q, Li J, et al. Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703-12 pubmed publisher
	Bai W, Zhu G, Xu J, Chen P, Meng F, Xue H, et al. The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Rep. 2021;36:109756 pubmed publisher
	Sun X, Liu M, Bai J, Xu J, Zhu C, Dong J, et al. ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage. J Leukoc Biol. 2021;110:1101-1112 pubmed publisher
	Iizuka T, Wakae K, Ono M, Suzuki T, Mizumoto Y, Kitamura K, et al. Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. Sci Rep. 2021;11:3833 pubmed publisher
	Delgado P, xc1 lvarez Prado x, Marina Z xe1 rate E, Sernández I, Mur S, de la Barrera J, et al. Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. PLoS Genet. 2020;16:e1008960 pubmed publisher
	Delgado Benito V, Berruezo Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, et al. PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification. J Exp Med. 2020;217: pubmed publisher
	Kim A, Han L, Yu K. Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions. Mol Cell Biol. 2020;: pubmed publisher
	Trivedi N, Weisel F, Smita S, Joachim S, Kader M, Radhakrishnan A, et al. Liver Is a Generative Site for the B Cell Response to Ehrlichia muris. Immunity. 2019;51:1088-1101.e5 pubmed publisher
	Methot S, Litzler L, Subramani P, Eranki A, Fifield H, Patenaude A, et al. A licensing step links AID to transcription elongation for mutagenesis in B cells. Nat Commun. 2018;9:1248 pubmed publisher
	Marina Zárate E, Pérez García A, Ramiro A. CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination. Front Immunol. 2017;8:1076 pubmed publisher
	Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214:1181-1198 pubmed publisher
	Fabbri G, Holmes A, Viganotti M, Scuoppo C, Belver L, Herranz D, et al. Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2017;114:E2911-E2919 pubmed publisher
	Compagno M, Wang Q, Pighi C, Cheong T, Meng F, Poggio T, et al. Phosphatidylinositol 3-kinase Î´ blockade increases genomic instability in B cells. Nature. 2017;542:489-493 pubmed publisher
	Wang Q, Kieffer Kwon K, Oliveira T, Mayer C, Yao K, Pai J, et al. The cell cycle restricts activation-induced cytidine deaminase activity to early G1. J Exp Med. 2017;214:49-58 pubmed publisher
	Montamat Sicotte D, Litzler L, Abreu C, Safavi S, Zahn A, Orthwein A, et al. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015;45:2365-76 pubmed publisher
	Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul A, et al. TGF-Î² suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. PLoS Pathog. 2015;11:e1004780 pubmed publisher
	Wang H, Geng J, Wen X, Bi E, Kossenkov A, Wolf A, et al. The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat Immunol. 2014;15:667-75 pubmed publisher
	Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS ONE. 2014;9:e94735 pubmed publisher
	Basso K, Schneider C, Shen Q, Holmes A, Setty M, Leslie C, et al. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. J Exp Med. 2012;209:2455-65 pubmed publisher
	Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science. 2009;323:1488-92 pubmed publisher
	Tsuji M, Suzuki K, Kitamura H, Maruya M, Kinoshita K, Ivanov I, et al. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity. 2008;29:261-71 pubmed publisher
	Kolar G, Mehta D, Pelayo R, Capra J. A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood. 2007;109:2545-52 pubmed
	Honjo T, Muramatsu M, Fagarasan S. AID: how does it aid antibody diversity?. Immunity. 2004;20:659-68 pubmed
	Okazaki I, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, et al. Constitutive expression of AID leads to tumorigenesis. J Exp Med. 2003;197:1173-81 pubmed
	Muramatsu M, Sankaranand V, Anant S, Sugai M, Kinoshita K, Davidson N, et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999;274:18470-6 pubmed

product information

Product Type :

Antibody

Product Name :

AID Monoclonal Antibody (mAID-2), eBioscience

Catalog # :

14-5959-80

Quantity :

25 µg

Price :

US 169.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Frozen): 20 µg/mL, Immunohistochemistry (Paraffin): 20 µg/mL, Western Blot: 20 µg/mL

Species :

Human, Mouse

Clone :

mAID-2

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 20 µg/mL, Immunohistochemistry (Paraffin): 20 µg/mL, Western Blot: 20 µg/mL

Aliases :

activation induced deaminase; activation-induced cytidine deaminase; Aicda; AID; Arp2; CDA2; Cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase

more info or order :

Invitrogen product webpage