AID Monoclonal Antibody (mAID-2), eBioscience | Invitrogen 14-5959-37 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AID Monoclonal Antibody (mAID-2), eBioscience

catalog :

14-5959-37

quantity :

2 mg

price :

US 1474.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

mAID-2

The same clone is also sold as:

Abcam: ab169522

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 16

Reference
Bai W, Zhu G, Xu J, Chen P, Meng F, Xue H, et al. The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Rep. 2021;36:109756 pubmed publisher
Sun X, Liu M, Bai J, Xu J, Zhu C, Dong J, et al. ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage. J Leukoc Biol. 2021;110:1101-1112 pubmed publisher
Iizuka T, Wakae K, Ono M, Suzuki T, Mizumoto Y, Kitamura K, et al. Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. Sci Rep. 2021;11:3833 pubmed publisher
Delgado P, xc1 lvarez Prado x, Marina Z xe1 rate E, Sernández I, Mur S, de la Barrera J, et al. Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. PLoS Genet. 2020;16:e1008960 pubmed publisher
Kim A, Han L, Yu K. Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions. Mol Cell Biol. 2020;: pubmed publisher
Trivedi N, Weisel F, Smita S, Joachim S, Kader M, Radhakrishnan A, et al. Liver Is a Generative Site for the B Cell Response to Ehrlichia muris. Immunity. 2019;51:1088-1101.e5 pubmed publisher
Methot S, Litzler L, Subramani P, Eranki A, Fifield H, Patenaude A, et al. A licensing step links AID to transcription elongation for mutagenesis in B cells. Nat Commun. 2018;9:1248 pubmed publisher
Marina Zárate E, Pérez García A, Ramiro A. CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination. Front Immunol. 2017;8:1076 pubmed publisher
Compagno M, Wang Q, Pighi C, Cheong T, Meng F, Poggio T, et al. Phosphatidylinositol 3-kinase Î´ blockade increases genomic instability in B cells. Nature. 2017;542:489-493 pubmed publisher
Wang Q, Kieffer Kwon K, Oliveira T, Mayer C, Yao K, Pai J, et al. The cell cycle restricts activation-induced cytidine deaminase activity to early G1. J Exp Med. 2017;214:49-58 pubmed publisher
Kalchschmidt J, Bashford Rogers R, Paschos K, Gillman A, Styles C, Kellam P, et al. Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells. J Exp Med. 2016;213:921-8 pubmed publisher
Montamat Sicotte D, Litzler L, Abreu C, Safavi S, Zahn A, Orthwein A, et al. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015;45:2365-76 pubmed publisher
Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul A, et al. TGF-Î² suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. PLoS Pathog. 2015;11:e1004780 pubmed publisher
Wang H, Geng J, Wen X, Bi E, Kossenkov A, Wolf A, et al. The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nat Immunol. 2014;15:667-75 pubmed publisher
Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS ONE. 2014;9:e94735 pubmed publisher
Basso K, Schneider C, Shen Q, Holmes A, Setty M, Leslie C, et al. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. J Exp Med. 2012;209:2455-65 pubmed publisher

product information

Product Type :

Antibody

Product Name :

AID Monoclonal Antibody (mAID-2), eBioscience

Catalog # :

14-5959-37

Quantity :

2 mg

Price :

US 1474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Frozen): 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL, Western Blot: 20 ug/mL

Species :

Human, Mouse

Clone :

mAID-2

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL, Western Blot: 20 ug/mL

Aliases :

activation induced deaminase; activation-induced cytidine deaminase; Aicda; AID; Arp2; CDA2; Cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase