product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FceR1 alpha Monoclonal Antibody (MAR-1), eBioscience™
catalog :
14-5898-85
quantity :
500 µg
price :
286 USD
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
MAR-1
reactivity :
mouse
application :
immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments, other
more info or order :
citations: 130
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; fig 3b
Wang H, Do D, Liu J, Wang B, Qu J, Ke X, et al. Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2018;141:586-600.e6 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig s1a
  • flow cytometry; mouse; fig s1a
Oh J, Oh D, Jung H, Lee H. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. 2017;114:E1188-E1195 pubmed publisher
  • flow cytometry; mouse; loading ...
Nakamura Y, Ishimaru K, Shibata S, Nakao A. Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Sci Rep. 2017;7:39934 pubmed publisher
  • flow cytometry; mouse; fig 3a
Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, et al. Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 2017;292:2924-2932 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Sektioglu I, Carretero R, Bulbuc N, Bald T, Tüting T, Rudensky A, et al. Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells. Cancer Res. 2017;77:291-302 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3D
Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
  • flow cytometry; mouse; loading ...
Mascarell L, Airouche S, Berjont N, Gary C, Gueguen C, Fourcade G, et al. The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation. Mucosal Immunol. 2017;10:695-704 pubmed publisher
  • flow cytometry; mouse; loading ...
Ramirez Carrozzi V, Sambandam A, Zhou M, Yan D, Kang J, Wu X, et al. Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone. J Allergy Clin Immunol. 2017;139:705-708.e6 pubmed publisher
  • flow cytometry; mouse
Henry E, Sy C, Inclan Rico J, Espinosa V, Ghanny S, Dwyer D, et al. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. 2016;213:1663-73 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1
Kim M, Taparowsky E, Kim C. Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut. Immunity. 2015;43:107-19 pubmed publisher
  • flow cytometry; mouse; tbl s1
Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 2015;463:739-45 pubmed publisher
  • flow cytometry; mouse
Schwartz C, Turqueti Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D. Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proc Natl Acad Sci U S A. 2014;111:E5169-77 pubmed publisher
  • flow cytometry; mouse; 10 ug/ml; fig 2b
Burton O, Logsdon S, Zhou J, Medina Tamayo J, Abdel Gadir A, Noval Rivas M, et al. Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. J Allergy Clin Immunol. 2014;134:1310-1317.e6 pubmed publisher
  • flow cytometry; mouse
Sheng K, Herrero L, Taylor A, Hapel A, Mahalingam S. IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages. PLoS ONE. 2014;9:e95208 pubmed publisher
  • flow cytometry; mouse; fig 1
Kim S, Prout M, Ramshaw H, Lopez A, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol. 2010;184:1143-7 pubmed publisher
  • other; mouse
  • flow cytometry; mouse
Sato K, Eizumi K, Fukaya T, Fujita S, Sato Y, Takagi H, et al. Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood. 2009;113:4780-9 pubmed publisher
  • flow cytometry; mouse
Fallon P, Ballantyne S, Mangan N, Barlow J, Dasvarma A, Hewett D, et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006;203:1105-16 pubmed
Kobayashi T, Shimabukuro Demoto S, Tsutsui H, Toyama Sorimachi N. Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis. PLoS Biol. 2019;17:e3000530 pubmed publisher
Liu C, Zhang X, Liu J, Wang Y, Sukhova G, Wojtkiewicz G, et al. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nat Commun. 2019;10:3978 pubmed publisher
Ford J, Hughson A, Lim K, Bardina S, Lu W, Charo I, et al. CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection. Front Immunol. 2018;9:3063 pubmed publisher
Potůčková L, Dráberová L, Hálová I, Paulenda T, Draber P. Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. Front Immunol. 2018;9:1771 pubmed publisher
Meroni E, Stakenborg N, Gomez Pinilla P, De Hertogh G, Goverse G, Matteoli G, et al. Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation. PLoS ONE. 2018;13:e0197487 pubmed publisher
Koga S, Hozumi K, Hirano K, Yazawa M, Terooatea T, Minoda A, et al. Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2. J Exp Med. 2018;215:1609-1626 pubmed publisher
Nemeth T, Futosi K, Szilveszter K, Vilinovszki O, Kiss Pápai L, Mocsai A. Lineage-Specific Analysis of Syk Function in Autoantibody-Induced Arthritis. Front Immunol. 2018;9:555 pubmed publisher
Garaycoechea J, Crossan G, Langevin F, Mulderrig L, Louzada S, Yang F, et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018;553:171-177 pubmed publisher
Dudeck J, Medyukhina A, Fröbel J, Svensson C, Kotrba J, Gerlach M, et al. Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med. 2017;214:3791-3811 pubmed publisher
Nakamura T, Fukaya T, Uto T, Takagi H, Arimura K, Tono T, et al. Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis. Biochem Biophys Rep. 2017;9:29-35 pubmed publisher
Niu R, Xiao X, Liu B, Li Y, Zhong Y, Ma L. Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b. Sci Rep. 2017;7:7409 pubmed publisher
Musio S, Costanza M, Poliani P, Fontana E, Cominelli M, Abolafio G, et al. Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin. Neurol Neuroimmunol Neuroinflamm. 2017;4:e342 pubmed publisher
Meurer S, Neß M, Weiskirchen S, Kim P, Tag C, Kauffmann M, et al. Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice. PLoS ONE. 2016;11:e0158104 pubmed publisher
Bambousková M, Polakovičová I, Hálová I, Goel G, Dráberová L, Bugajev V, et al. New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. Mol Cell Biol. 2016;36:1366-82 pubmed publisher
Patel K, AVEN L, Shao F, Krishnamoorthy N, Duvall M, Levy B, et al. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016;9:1466-1476 pubmed publisher
Oh J, Kim B, Chang D, Kwon M, Lee S, Kang D, et al. Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa. Proc Natl Acad Sci U S A. 2016;113:E762-71 pubmed publisher
Lee Y, Liu C, Liao M, Sukhova G, Shirakawa J, Abdennour M, et al. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015;156:4047-58 pubmed publisher
Mintern J, Macri C, Chin W, Panozza S, Segura E, Patterson N, et al. Differential use of autophagy by primary dendritic cells specialized in cross-presentation. Autophagy. 2015;11:906-17 pubmed publisher
Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, et al. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014;20:1340-1347 pubmed publisher
Hancock D, Shklovskaya E, Guy T, Falsafi R, Fjell C, Ritchie W, et al. A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells. PLoS ONE. 2014;9:e100613 pubmed publisher
Campbell I, Miescher S, Branch D, Mott P, Lazarus A, Han D, et al. Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils. J Immunol. 2014;192:5031-8 pubmed publisher
Zhong W, Su W, Zhang Y, Liu Q, Wu J, Di C, et al. Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation. Immunology. 2014;142:202-15 pubmed publisher
Ishijima Y, Ohmori S, Ohneda K. Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice. FEBS Open Bio. 2013;4:18-24 pubmed publisher
Leyva Castillo J, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, et al. Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun. 2013;4:2847 pubmed publisher
Siegel A, Stone K, Cruse G, Lawrence M, Olivera A, Jung M, et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 2013;132:1388-96 pubmed publisher
Khodoun M, Kucuk Z, Strait R, Krishnamurthy D, Janek K, Clay C, et al. Rapid desensitization of mice with anti-Fc?RIIb/Fc?RIII mAb safely prevents IgG-mediated anaphylaxis. J Allergy Clin Immunol. 2013;132:1375-87 pubmed publisher
Tung H, Plunkett B, Huang S, Zhou Y. Murine mast cells secrete and respond to interleukin-33. J Interferon Cytokine Res. 2014;34:141-7 pubmed publisher
Suzukawa M, Miller M, Rosenthal P, Cho J, Doherty T, Varki A, et al. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013;190:5939-48 pubmed publisher
Doyle A, Jacobsen E, Ochkur S, Willetts L, Shim K, Neely J, et al. Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. J Leukoc Biol. 2013;94:17-24 pubmed publisher
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, et al. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013;14:554-63 pubmed publisher
Roediger B, Kyle R, Yip K, Sumaria N, Guy T, Kim B, et al. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol. 2013;14:564-73 pubmed publisher
Yang Q, Monticelli L, Saenz S, Chi A, Sonnenberg G, Tang J, et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013;38:694-704 pubmed publisher
Lee Y, Kumagai Y, Jang M, Kim J, Yang B, Lee E, et al. Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1? stimulation. J Immunol. 2013;190:5296-305 pubmed publisher
Fukuishi N, Igawa Y, Kunimi T, Hamano H, Toyota M, Takahashi H, et al. Generation of mast cells from mouse fetus: analysis of differentiation and functionality, and transcriptome profiling using next generation sequencer. PLoS ONE. 2013;8:e60837 pubmed publisher
Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, et al. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J Immunol. 2013;190:4489-99 pubmed publisher
Nabe T, Matsuya K, Akamizu K, Fujita M, Nakagawa T, Shioe M, et al. Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice. Br J Pharmacol. 2013;169:462-76 pubmed publisher
Moniaga C, Jeong S, Egawa G, Nakajima S, Hara Chikuma M, Jeon J, et al. Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. Am J Pathol. 2013;182:841-51 pubmed publisher
Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed publisher
Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, et al. Sequential engagement of Fc?RI on Mast Cells and Basophil Histamine H(4) Receptor and Fc?RI in Allergic Rhinitis. J Immunol. 2013;190:539-48 pubmed publisher
Giacomin P, Siracusa M, Walsh K, Grencis R, Kubo M, Comeau M, et al. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol. 2012;189:4371-8 pubmed publisher
Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, et al. Regulation of GATA factor expression is distinct between erythroid and mast cell lineages. Mol Cell Biol. 2012;32:4742-55 pubmed publisher
Dahlin J, Feinstein R, Cui Y, Heyman B, Hallgren J. CD11c+ cells are required for antigen-induced increase of mast cells in the lung. J Immunol. 2012;189:3869-77 pubmed publisher
Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss M, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A. 2012;109:14954-9 pubmed publisher
Garaycoechea J, Crossan G, Langevin F, Daly M, Arends M, Patel K. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature. 2012;489:571-5 pubmed publisher
Piliponsky A, Chen C, Rios E, Treuting P, Lahiri A, Abrink M, et al. The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol. 2012;181:875-86 pubmed publisher
Kawahara T. Establishment and characterization of mouse bone marrow-derived mast cell hybridomas. Exp Cell Res. 2012;318:2385-96 pubmed publisher
Larson D, Hübner M, Torrero M, Morris C, Brankin A, Swierczewski B, et al. Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. J Immunol. 2012;188:4188-99 pubmed publisher
Hill D, Siracusa M, Abt M, Kim B, Kobuley D, Kubo M, et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med. 2012;18:538-46 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Nie X, Cai G, Zhang W, Wang H, Wu B, Li Q, et al. Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis. Clin Immunol. 2012;142:269-79 pubmed publisher
Forbes Blom E, Camberis M, Prout M, Tang S, Le Gros G. Staphylococcal-derived superantigen enhances peanut induced Th2 responses in the skin. Clin Exp Allergy. 2012;42:305-14 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Park K, Park J, Yang W, Lee J, Song M, Kim H. Transcriptional activation of the IL31 gene by NFAT and STAT6. J Leukoc Biol. 2012;91:245-57 pubmed publisher
Lilla J, Chen C, Mukai K, Benbarak M, Franco C, Kalesnikoff J, et al. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood. 2011;118:6930-8 pubmed publisher
Suzuki K, Murphy S, Xia Y, Yokota M, Nakagomi D, Liu F, et al. Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS ONE. 2011;6:e25412 pubmed publisher
Hübner M, Larson D, Torrero M, Mueller E, Shi Y, Killoran K, et al. Anti-Fc?R1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice. Clin Immunol. 2011;141:205-17 pubmed publisher
Tawara I, Nieves E, Liu C, Evers R, Toubai T, Sun Y, et al. Host basophils are dispensable for induction of donor T helper 2 cell differentiation and severity of experimental graft-versus-host disease. Biol Blood Marrow Transplant. 2011;17:1747-53 pubmed publisher
Anthony R, Kobayashi T, Wermeling F, Ravetch J. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011;475:110-3 pubmed publisher
Schneider E, Machavoine F, Bricard Rignault R, Levasseur M, Petit Bertron A, Gautron S, et al. Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. J Allergy Clin Immunol. 2011;128:864-871.e2 pubmed publisher
Kageyama Yahara N, Suehiro Y, Yamamoto T, Kadowaki M. Rab5a regulates surface expression of Fc?RI and functional activation in mast cells. Biol Pharm Bull. 2011;34:760-3 pubmed
Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, et al. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE. 2011;6:e18404 pubmed publisher
Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol. 2011;186:5766-71 pubmed publisher
McDonald J, Cortini A, Rosas M, Fossati Jimack L, Ling G, Lewis K, et al. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB J. 2011;25:1972-82 pubmed publisher
Piconese S, Costanza M, Musio S, Tripodo C, Poliani P, Gri G, et al. Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice. Lab Invest. 2011;91:627-41 pubmed publisher
Nakagawa Y, Takamatsu H, Okuno T, Kang S, Nojima S, Kimura T, et al. Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses. J Immunol. 2011;186:2881-8 pubmed publisher
van Panhuys N, Prout M, Forbes E, Min B, Paul W, Le Gros G. Basophils are the major producers of IL-4 during primary helminth infection. J Immunol. 2011;186:2719-28 pubmed publisher
Kawahara T, Iizuka T. Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells. Cytotechnology. 2011;63:143-52 pubmed publisher
Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, et al. Adjuvants determine the contribution of basophils to antigen sensitization in vivo. Immunol Lett. 2011;136:49-54 pubmed publisher
Kawahara T. Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells. Anim Sci J. 2010;81:714-21 pubmed publisher
Rodriguez Gomez M, Talke Y, Goebel N, Hermann F, Reich B, Mack M. Basophils support the survival of plasma cells in mice. J Immunol. 2010;185:7180-5 pubmed publisher
Qi Y, Operario D, Oberholzer C, Kobie J, Looney R, Georas S, et al. Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol. 2010;126:1260-6.e4 pubmed publisher
Kalesnikoff J, Galli S. Antiinflammatory and immunosuppressive functions of mast cells. Methods Mol Biol. 2011;677:207-20 pubmed publisher
Cheung D, Ehlenbach S, Kitchens R, Riley D, Thomas L, Holtzman M, et al. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol. 2010;185:4983-7 pubmed publisher
Wang X, Reece S, Van Scott M, Brown J. A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro. Brain Behav Immun. 2011;25:127-34 pubmed publisher
de Vries V, Elgueta R, Lee D, Noelle R. Mast cell protease 6 is required for allograft tolerance. Transplant Proc. 2010;42:2759-62 pubmed publisher
Phythian Adams A, Cook P, Lundie R, Jones L, Smith K, Barr T, et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med. 2010;207:2089-96 pubmed publisher
Freire T, Zhang X, Deriaud E, Ganneau C, Vichier Guerre S, Azria E, et al. Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. Blood. 2010;116:3526-36 pubmed publisher
Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, et al. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 2010;120:2867-75 pubmed publisher
Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, et al. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood. 2010;116:2665-75 pubmed publisher
Kageyama Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, et al. Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo. FEBS Lett. 2010;584:111-8 pubmed publisher
Gaudenzio N, Espagnolle N, Mars L, Liblau R, Valitutti S, Espinosa E. Cell-cell cooperation at the T helper cell/mast cell immunological synapse. Blood. 2009;114:4979-88 pubmed publisher
de Vries V, Wasiuk A, Bennett K, Benson M, Elgueta R, Waldschmidt T, et al. Mast cell degranulation breaks peripheral tolerance. Am J Transplant. 2009;9:2270-80 pubmed publisher
Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, et al. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation. Blood. 2009;114:2639-48 pubmed publisher
Moore M, Newcomb D, Parekh V, Van Kaer L, Collins R, Zhou W, et al. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009;183:2016-26 pubmed publisher
Ota T, Aoki Ota M, Duong B, Nemazee D. Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. J Immunol. 2009;182:8110-7 pubmed publisher
Perrigoue J, Saenz S, Siracusa M, Allenspach E, Taylor B, Giacomin P, et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009;10:697-705 pubmed publisher
Charles N, Watford W, Ramos H, Hellman L, Oettgen H, Gomez G, et al. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity. 2009;30:533-43 pubmed publisher
Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, et al. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol. 2009;123:74-81.e1 pubmed publisher
Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008;181:5653-9 pubmed
Nakano N, Nishiyama C, Tokura T, Nagasako Akazome Y, Ohtake Y, Okumura K, et al. Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation. Int Arch Allergy Immunol. 2008;147:213-21 pubmed publisher
Kondo Y, Yoshimoto T, Yasuda K, Futatsugi Yumikura S, Morimoto M, Hayashi N, et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol. 2008;20:791-800 pubmed publisher
Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, et al. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food. 2008;11:14-20 pubmed publisher
Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008;28:581-9 pubmed publisher
Sokol C, Barton G, Farr A, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008;9:310-8 pubmed publisher
Grayson M, Cheung D, Rohlfing M, Kitchens R, Spiegel D, Tucker J, et al. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med. 2007;204:2759-69 pubmed
Ho L, Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M, et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol. 2007;82:1481-90 pubmed
Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, et al. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007;110:913-20 pubmed
Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, et al. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood. 2007;109:4846-55 pubmed
Oh K, Shen T, Le Gros G, Min B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood. 2007;109:2921-7 pubmed
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product information
Product Type :
Antibody
Product Name :
FceR1 alpha Monoclonal Antibody (MAR-1), eBioscience™
Catalog # :
14-5898-85
Quantity :
500 µg
Price :
286 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent
Species :
Mouse
Clone :
MAR-1
Isotype :
IgG
Storage :
4° C
Description :
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent
Aliases :
fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RP11-550P17.3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA