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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IgM Monoclonal Antibody (eB121-15F9), eBioscience™
catalog :
14-5890-85
quantity :
500 µg
price :
176 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eB121-15F9
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Chen M, Chen Y, Wu M, Yu G, Lin W, Tan T, et al. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS ONE. 2014;9:e107505 pubmed publisher
Goldstein J, Valido A, Lewandowski J, Walker R, Mills M, Messemer K, et al. Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus. Sci Rep. 2019;9:18613 pubmed publisher
Szappanos D, Tschismarov R, Perlot T, Westermayer S, Fischer K, Platanitis E, et al. The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS Pathog. 2018;14:e1007397 pubmed publisher
Koohy H, Bolland D, Matheson L, Schoenfelder S, Stellato C, Dimond A, et al. Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells. Genome Biol. 2018;19:126 pubmed publisher
Anders P, Montgomery N, Montgomery S, Bhatt A, Dittmer D, Damania B. Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. J Clin Invest. 2018;128:2519-2534 pubmed publisher
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam A, Sattentau Q, Meinhart A, et al. RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Mol Cell. 2018;70:650-662.e8 pubmed publisher
Guzman H, Sanders K, Idica A, Bochnakian A, Jury D, Daugaard I, et al. miR-128 inhibits telomerase activity by targeting TERT mRNA. Oncotarget. 2018;9:13244-13253 pubmed publisher
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed publisher
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed publisher
El Zaatari M, Bass A, Bowlby R, Zhang M, Syu L, Yang Y, et al. Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity. Gastroenterology. 2018;154:140-153.e17 pubmed publisher
Lindner S, Lohmüller M, Kotkamp B, Schüler F, Knust Z, Villunger A, et al. The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells. EMBO Rep. 2017;18:1604-1617 pubmed publisher
van Nieuwenhuijze A, Dooley J, Humblet Baron S, Sreenivasan J, Koenders M, Schlenner S, et al. Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice. Cell Mol Life Sci. 2017;74:2095-2106 pubmed publisher
Alrefai H, Muhammad K, Rudolf R, Pham D, Klein Hessling S, Patra A, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724 pubmed publisher
Knackmuss U, Lindner S, Aneichyk T, Kotkamp B, Knust Z, Villunger A, et al. MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells. Cell Death Differ. 2016;23:242-52 pubmed publisher
Limon J, So L, Jellbauer S, Chiu H, Corado J, Sykes S, et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A. 2014;111:E5076-85 pubmed publisher
Tu M, Mahmoud A, Wight A, Mottashed A, Belanger S, Rahim M, et al. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 2014;74:3684-94 pubmed publisher
Filbey K, Grainger J, Smith K, Boon L, Van Rooijen N, Harcus Y, et al. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunol Cell Biol. 2014;92:436-48 pubmed publisher
Ding Z, Bergman A, Rutemark C, Ouchida R, Ohno H, Wang J, et al. Complement-activating IgM enhances the humoral but not the T cell immune response in mice. PLoS ONE. 2013;8:e81299 pubmed publisher
Donius L, Handy J, Weis J, Weis J. Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol. 2013;191:434-47 pubmed publisher
Zhong M, Veillette A. Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity. Mol Cell Biol. 2013;33:1223-32 pubmed publisher
Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, et al. Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol. 2012;188:1809-18 pubmed publisher
Allman W, Saini S, Tuzun E, Christadoss P. Characterization of peripheral blood acetylcholine receptor-binding B cells in experimental myasthenia gravis. Cell Immunol. 2011;271:292-8 pubmed publisher
Wang J, Lee J, Yan M, Rho J, Roehrl M. Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity. Am J Pathol. 2011;178:2168-76 pubmed publisher
Shiokawa A, Tanabe K, Tsuji N, Sato R, Hachimura S. IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance. Immunol Lett. 2009;125:7-14 pubmed publisher
Benatar T, Cao M, Lee Y, Li H, Feng N, Gu X, et al. Virulizin induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors. Cancer Immunol Immunother. 2008;57:1757-69 pubmed publisher
Chen X, Esplin B, Garrett K, Welner R, Webb C, Kincade P. Retinoids accelerate B lineage lymphoid differentiation. J Immunol. 2008;180:138-45 pubmed
Onai N, Obata Onai A, Schmid M, Ohteki T, Jarrossay D, Manz M. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007;8:1207-16 pubmed
Burchill M, Yang J, Vogtenhuber C, Blazar B, Farrar M. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007;178:280-90 pubmed
Nojima T, Hayashi K, Goitsuka R, Nakayama K, Nakayama K, Kitamura D. Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation. Immunol Lett. 2006;105:48-54 pubmed
product information
Product Type :
Antibody
Product Name :
IgM Monoclonal Antibody (eB121-15F9), eBioscience™
Catalog # :
14-5890-85
Quantity :
500 µg
Price :
176 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay-Dependent
Species :
Mouse
Clone :
eB121-15F9
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
IgM is expressed intracellularly, during early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent
Aliases :
AGM1; AI326478; Igh6; Igh-6; IGHM; Igh-M; Igm; immunoglobulin heavy chain 6; immunoglobulin heavy constant mu; MU; muH; RGD1359202; VH
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA