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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Integrin alpha 4 beta 7 (LPAM-1) Monoclonal Antibody (DATK32 (DATK-32)), eBioscience™
catalog :
14-5887-82
quantity :
100 µg
price :
99.5 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
DATK32 (DATK-32)
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 43
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Yuan X, Dee M, Altman N, Malek T. IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa. J Immunol. 2015;194:1334-46 pubmed publisher
  • flow cytometry; mouse; 1:100
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
Chen L, Nicholson Y, Rosborough B, Thomson A, Raimondi G. A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells. J Immunol. 2016;197:1137-47 pubmed publisher
Do J, Visperas A, Freeman M, Iwakura Y, Oukka M, Min B. Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and ?? T cells. Immunol Cell Biol. 2014;92:90-8 pubmed publisher
Hwang I, Park C, Luong T, Harrison K, Birnbaumer L, Kehrl J. The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome. PLoS ONE. 2013;8:e72596 pubmed publisher
Brinkman C, Rouhani S, Srinivasan N, Engelhard V. Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells. J Immunol. 2013;191:2412-25 pubmed publisher
Radulovic K, Rossini V, Manta C, Holzmann K, Kestler H, Niess J. The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS ONE. 2013;8:e65413 pubmed publisher
Seo G, Jang Y, Kim H, Lee M, Park M, Park S, et al. Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-?1 to enhance the overall IgA response. J Leukoc Biol. 2013;94:325-35 pubmed publisher
Bäuerlein C, Riedel S, Baker J, Brede C, Garrote A, Chopra M, et al. A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model. BMC Med. 2013;11:134 pubmed publisher
Kawabe T, Sun S, Fujita T, Yamaki S, Asao A, Takahashi T, et al. Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. J Immunol. 2013;190:5788-98 pubmed publisher
Agnello D, Denimal D, Lavaux A, Blondeau Germe L, Lu B, Gerard N, et al. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol. 2013;190:4836-47 pubmed publisher
Chen X, Dodge J, Komorowski R, Drobyski W. A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. Blood. 2013;121:3970-80 pubmed publisher
Bouladoux N, Hall J, Grainger J, dos Santos L, Kann M, Nagarajan V, et al. Regulatory role of suppressive motifs from commensal DNA. Mucosal Immunol. 2012;5:623-34 pubmed publisher
Jiang X, Clark R, Liu L, Wagers A, Fuhlbrigge R, Kupper T. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012;483:227-31 pubmed publisher
Sugiyama M, Nakato G, Jinnohara T, Akiba H, Okumura K, Ohno H, et al. Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development. Int Immunol. 2012;24:369-78 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Thomas S, Scanlon S, Griewank K, Constantinides M, Savage A, Barr K, et al. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med. 2011;208:1179-88 pubmed publisher
Ciabattini A, Pettini E, Fiorino F, Prota G, Pozzi G, Medaglini D. Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice. PLoS ONE. 2011;6:e19346 pubmed publisher
Hall J, Cannons J, Grainger J, Dos Santos L, Hand T, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34:435-47 pubmed publisher
Tachibana M, Tenno M, Tezuka C, Sugiyama M, Yoshida H, Taniuchi I. Runx1/Cbf?2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages. J Immunol. 2011;186:1450-7 pubmed publisher
Karlsson F, Robinson Jackson S, Gray L, Zhang S, Grisham M. Ex vivo generation of regulatory T cells: characterization and therapeutic evaluation in a model of chronic colitis. Methods Mol Biol. 2011;677:47-61 pubmed publisher
Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song S, et al. Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins. J Immunol. 2010;185:5289-99 pubmed publisher
Ryan G, Wang C, Chamberlain J, Attridge K, Schmidt E, Kenefeck R, et al. B1 cells promote pancreas infiltration by autoreactive T cells. J Immunol. 2010;185:2800-7 pubmed publisher
Douglas D, Beiting D, Loftus J, Appleton J, Bliss S. Combinatorial effects of interleukin 10 and interleukin 4 determine the progression of hepatic inflammation following murine enteric parasitic infection. Hepatology. 2010;51:2162-71 pubmed publisher
Ciabattini A, Pettini E, Arsenijevic S, Pozzi G, Medaglini D. Intranasal immunization with vaccine vector Streptococcus gordonii elicits primed CD4+ and CD8+ T cells in the genital and intestinal tracts. Vaccine. 2010;28:1226-33 pubmed publisher
Withers D, Jaensson E, Gaspal F, McConnell F, Eksteen B, Anderson G, et al. The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals. J Immunol. 2009;183:5079-84 pubmed publisher
Olson J, Zeiser R, Beilhack A, Goldman J, Negrin R. Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol. 2009;183:3219-28 pubmed publisher
Carlow D, Gold M, Ziltener H. Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells. J Immunol. 2009;183:1155-65 pubmed publisher
Sharma R, Sung S, Abaya C, Ju A, Fu S, Ju S. IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol. 2009;183:1065-73 pubmed publisher
Pettini E, Ciabattini A, Pozzi G, Medaglini D. Adoptive transfer of transgenic T cells to study mucosal adjuvants. Methods. 2009;49:340-5 pubmed publisher
Petty J, Lenox C, Weiss D, Poynter M, Suratt B. Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow. J Immunol. 2009;182:604-12 pubmed
Brinkman C, Sheasley O neill S, Ferguson A, Engelhard V. Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics. J Immunol. 2008;181:1814-24 pubmed
Lee S, Park Y, So T, Kwon B, Cheroutre H, Mittler R, et al. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008;9:917-26 pubmed publisher
Thompson J, Whitmore A, Staats H, Johnston R. Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine. 2008;26:4267-75 pubmed publisher
Thompson J, Nicholson M, Whitmore A, Zamora M, West A, Iwasaki A, et al. Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. J Immunol. 2008;181:574-85 pubmed
Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H. Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology. 2008;125:38-47 pubmed publisher
Desanti G, Cumano A, Golub R. Identification of CD4int progenitors in mouse fetal spleen, a source of resident lymphoid cells. J Leukoc Biol. 2008;83:1145-54 pubmed publisher
Enioutina E, Bareyan D, Daynes R. TLR ligands that stimulate the metabolism of vitamin D3 in activated murine dendritic cells can function as effective mucosal adjuvants to subcutaneously administered vaccines. Vaccine. 2008;26:601-13 pubmed publisher
Sun C, Hall J, Blank R, Bouladoux N, Oukka M, Mora J, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204:1775-85 pubmed
Bliss S, Bliss S, Beiting D, Alcaraz A, Appleton J. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. J Immunol. 2007;178:7974-83 pubmed
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten L, Ceredig R, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007;26:643-54 pubmed
Priestley G, Scott L, Ulyanova T, Papayannopoulou T. Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity. Blood. 2006;107:2959-67 pubmed
Berlin C, Berg E, Briskin M, Andrew D, Kilshaw P, Holzmann B, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74:185-95 pubmed
product information
Product Type :
Antibody
Product Name :
Integrin alpha 4 beta 7 (LPAM-1) Monoclonal Antibody (DATK32 (DATK-32)), eBioscience™
Catalog # :
14-5887-82
Quantity :
100 µg
Price :
99.5 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Species :
Mouse
Clone :
DATK32 (DATK-32)
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Aliases :
CD49 antigen-like family member D; CD49d; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin beta 7; Integrin beta-7; Integrin beta-P; Itga4; Itga4B; Itgb7; LPAM subunit alpha; Ly69; Lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; VLA; VLA 4; VLA-4 receptor, alpha 4 subunit; VLA4 subunit alpha; VLA-4 subunit alpha
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA