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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-49H Monoclonal Antibody (3D10), eBioscience™
catalog :
14-5886-82
quantity :
100µg
price :
US 139
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3D10
reactivity :
mouse
application :
immunoprecipitation, flow cytometry
more info or order :
Invitrogen product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 6e
Bern M, Parikh B, Yang L, Beckman D, Poursine Laurent J, Yokoyama W. Inducible down-regulation of MHC class I results in natural killer cell tolerance. J Exp Med. 2019;216:99-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Jensen I, Winborn C, Fosdick M, Shao P, Tremblay M, Shan Q, et al. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 2018;14:e1007405 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Abel A, Tiwari A, Gerbec Z, Siebert J, Yang C, Schloemer N, et al. IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. Front Immunol. 2018;9:1168 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6b
Bern M, Beckman D, Ebihara T, Taffner S, Poursine Laurent J, White J, et al. Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor. Proc Natl Acad Sci U S A. 2017;114:E8440-E8447 pubmed publisher
  • flow cytometry; mouse; fig s1
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
Almishaal A, Mathur P, Hillas E, Chen L, Zhang A, Yang J, et al. Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice. PLoS Pathog. 2017;13:e1006599 pubmed publisher
Hamblet C, Makowski S, Tritapoe J, Pomerantz J. NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. J Immunol. 2016;196:2614-26 pubmed publisher
Doorduijn E, Sluijter M, Querido B, Oliveira C, Achour A, Ossendorp F, et al. TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. J Clin Invest. 2016;126:784-94 pubmed publisher
O Sullivan T, Johnson L, Kang H, Sun J. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015;43:331-42 pubmed publisher
Freeman B, Raué H, Hill A, Slifka M. Cytokine-Mediated Activation of NK Cells during Viral Infection. J Virol. 2015;89:7922-31 pubmed publisher
Nandagopal N, Ali A, Komal A, Lee S. The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions. Front Immunol. 2014;5:187 pubmed publisher
Sojka D, Plougastel Douglas B, Yang L, Pak Wittel M, Artyomov M, Ivanova Y, et al. Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells. elife. 2014;3:e01659 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Merino E, Abeyweera T, Firth M, Zawislak C, Basu R, Liu X, et al. Protein kinase C-? clustering at immunological synapses amplifies effector responses in NK cells. J Immunol. 2012;189:4859-69 pubmed publisher
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed publisher
Lee G, Liou Y, Wang S, Ko K, Jiang S, Liao N. Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol. 2011;187:1212-21 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, Kolbe T, et al. A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood. 2011;117:1565-73 pubmed publisher
Beilke J, Benjamin J, Lanier L. The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient. Blood. 2010;116:5208-16 pubmed publisher
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold C, et al. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010;107:9759-64 pubmed publisher
Fodil Cornu N, Pyzik M, Vidal S. Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus. Methods Mol Biol. 2010;612:393-409 pubmed publisher
Orr M, Sun J, Hesslein D, Arase H, Phillips J, Takai T, et al. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J Exp Med. 2009;206:807-17 pubmed publisher
Chen S, Kawashima H, Lowe J, Lanier L, Fukuda M. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med. 2005;202:1679-89 pubmed
Caraux A, Kim N, Bell S, Zompi S, Ranson T, Lesjean Pottier S, et al. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 2006;107:994-1002 pubmed
Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed
Brown M, Dokun A, Heusel J, Smith H, Beckman D, Blattenberger E, et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 2001;292:934-7 pubmed
Smith H, Chuang H, Wang L, Salcedo M, Heusel J, Yokoyama W. Nonstochastic coexpression of activation receptors on murine natural killer cells. J Exp Med. 2000;191:1341-54 pubmed
product information
Product Type :
Antibody
Product Name :
Ly-49H Monoclonal Antibody (3D10), eBioscience™
Catalog # :
14-5886-82
Quantity :
100µg
Price :
US 139
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Species :
Mouse
Clone :
3D10
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly49H is expressed in a subset of NK cells but not NKT (NK1.1/CD3+) cells. Natural killer cells can express several Ly49 proteins.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Aliases :
Cmv1; Cmv-1; cytomegalovirus resistance 1; Killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u ; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA