MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™ | Invitrogen 14-5863-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™

catalog :

14-5863-82

quantity :

100µg

price :

US 139

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

5D10

reactivity :

mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:75	Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
	Nam J, Son S, Ochyl L, Kuai R, Schwendeman A, Moon J. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Commun. 2018;9:1074 pubmed publisher
	Tu M, Mahmoud A, Wight A, Mottashed A, Belanger S, Rahim M, et al. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 2014;74:3684-94 pubmed publisher
	Nakata J, Nakano K, Okumura A, Mizutani Y, Kinoshita H, Iwai M, et al. In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity. Leukemia. 2014;28:1316-25 pubmed publisher
	Kroesen M, Nierkens S, Ansems M, Wassink M, Orentas R, Boon L, et al. A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma. Int J Cancer. 2014;134:1335-45 pubmed publisher
	Li Z, Zhang C, Zhou Z, Zhang J, Zhang J, Tian Z. Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor ?? are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection. Infect Immun. 2012;80:565-74 pubmed publisher
	Schmidt R, Filak H, Lemon J, Potter T, Lenz L. A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog. 2011;7:e1002368 pubmed publisher
	Prajeeth C, Haeberlein S, Sebald H, Schleicher U, Bogdan C. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun. 2011;79:2699-708 pubmed publisher
	Mishra R, Chen A, Welsh R, Szomolanyi Tsuda E. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog. 2010;6:e1000924 pubmed publisher
	Grabig A, Paclik D, Guzy C, Dankof A, Baumgart D, Erckenbrecht J, et al. Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways. Infect Immun. 2006;74:4075-82 pubmed
	Bui J, Carayannopoulos L, Lanier L, Yokoyama W, Schreiber R. IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. J Immunol. 2006;176:905-13 pubmed
	Bahram S, Inoko H, Shiina T, Radosavljevic M. MIC and other NKG2D ligands: from none to too many. Curr Opin Immunol. 2005;17:505-9 pubmed
	Krmpotic A, Hasan M, Loewendorf A, Saulig T, Halenius A, Lenac T, et al. NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145. J Exp Med. 2005;201:211-20 pubmed
	Diefenbach A, Jamieson A, Liu S, Shastri N, Raulet D. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol. 2000;1:119-26 pubmed

product information

Product Type :

Antibody

Product Name :

MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™

Catalog # :

14-5863-82

Quantity :

100µg

Price :

US 139

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Mouse, Rat

Clone :

5D10

Isotype :

IgG

Storage :

4° C

Description :

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

A430108B07Rik; ALCAN-beta; MULT1; N2DL1; N2DL-1; NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; NKG2DL1; RAET1I; Retinoic acid early transcript 1I; UL16 binding protein 1; UL16-binding protein 1; UL16-binding protein-like transcript 1; ULBP; ULBP 1; ULBP1

more info or order :

Invitrogen product webpage