MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™ | Invitrogen 14-5863-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™

catalog :

14-5863-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

5D10

reactivity :

mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 3

Reference
Nam J, Son S, Ochyl L, Kuai R, Schwendeman A, Moon J. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Commun. 2018;9:1074 pubmed publisher
Tu M, Mahmoud A, Wight A, Mottashed A, Belanger S, Rahim M, et al. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 2014;74:3684-94 pubmed publisher
Schmidt R, Filak H, Lemon J, Potter T, Lenz L. A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog. 2011;7:e1002368 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™

Catalog # :

14-5863-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Mouse, Rat

Clone :

5D10

Isotype :

IgG

Storage :

4° C

Description :

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

A430108B07Rik; ALCAN-beta; MULT1; N2DL1; N2DL-1; NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; NKG2DL1; RAET1I; Retinoic acid early transcript 1I; UL16 binding protein 1; UL16-binding protein 1; UL16-binding protein-like transcript 1; ULBP; ULBP 1; Ulbp1