This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD309 (FLK1) Monoclonal Antibody (Avas12a1), eBioscience™
catalog :
14-5821-81
quantity :
50 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
Avas12a1
reactivity :
mouse
application :
western blot, immunohistochemistry, flow cytometry
citations: 25
Reference
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez Anguita N, et al. Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis. elife. 2018;7: pubmed publisher
Murray L, Habiel D, Hohmann M, Camelo A, Shang H, Zhou Y, et al. Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis. JCI Insight. 2017;2: pubmed publisher
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro Oonuma T, Hwang Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2017;2:e90905 pubmed publisher
Wu L, Wary K, REVSKOY S, Gao X, Tsang K, Komarova Y, et al. Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports. 2015;5:10-21 pubmed publisher
Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, et al. Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice. Mol Carcinog. 2016;55:882-96 pubmed publisher
Yamamizu K, Schlessinger D, Ko M. SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1). Development. 2014;141:4254-66 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Shi X, Richard J, Zirbes K, Gong W, Lin G, Kyba M, et al. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol. 2014;389:208-18 pubmed publisher
Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, et al. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells. 2014;32:191-203 pubmed publisher
Rasmussen T, Martin C, Walter C, Shi X, Perlingeiro R, Koyano Nakagawa N, et al. Etv2 rescues Flk1 mutant embryoid bodies. Genesis. 2013;51:471-80 pubmed publisher
Behrens A, Iacovino M, Lohr J, Ren Y, Zierold C, Harvey R, et al. Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10. Stem Cells Dev. 2013;22:2211-20 pubmed publisher
Rasmussen T, Shi X, Wallis A, Kweon J, Zirbes K, Koyano Nakagawa N, et al. VEGF/Flk1 signaling cascade transactivates Etv2 gene expression. PLoS ONE. 2012;7:e50103 pubmed publisher
Sountoulidis A, Stavropoulos A, Giaglis S, Apostolou E, Monteiro R, Chuva de Sousa Lopes S, et al. Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair. PLoS ONE. 2012;7:e41460 pubmed publisher
Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
Jayaraman P, Parikh F, López Rivera E, Hailemichael Y, Clark A, Ma G, et al. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol. 2012;188:5365-76 pubmed publisher
van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, et al. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep. 2012;13:355-62 pubmed publisher
Mukouyama Y, James J, Nam J, Uchida Y. Whole-mount confocal microscopy for vascular branching morphogenesis. Methods Mol Biol. 2012;843:69-78 pubmed publisher
Warram J, Sorace A, Saini R, Umphrey H, Zinn K, Hoyt K. A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature. J Ultrasound Med. 2011;30:921-31 pubmed
Schenke Layland K, Nsair A, Van Handel B, Angelis E, Gluck J, Votteler M, et al. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011;32:2748-56 pubmed publisher
Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, et al. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells. 2010;28:1465-75 pubmed publisher
Huusko J, Merentie M, Dijkstra M, Ryhänen M, Karvinen H, Rissanen T, et al. The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice. Cardiovasc Res. 2010;86:122-30 pubmed publisher
Asahina K, Tsai S, Li P, Ishii M, Maxson R, Sucov H, et al. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009;49:998-1011 pubmed publisher
Barkho B, Munoz A, Li X, Li L, Cunningham L, Zhao X. Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells. 2008;26:3139-49 pubmed publisher
Willmann J, Cheng Z, Davis C, Lutz A, Schipper M, Nielsen C, et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology. 2008;249:212-9 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD309 (FLK1) Monoclonal Antibody (Avas12a1), eBioscience™
Catalog # :
14-5821-81
Quantity :
50 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Mouse
Clone :
Avas12a1
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
6130401C07; CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor Flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; Vegfr-2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA