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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IgM Monoclonal Antibody (II/41), eBioscience™
catalog :
14-5790-82
quantity :
100µg
price :
US 108
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
II/41
reactivity :
mouse
application :
ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig s8a
Mayer C, Gazumyan A, Kara E, Gitlin A, Golijanin J, Viant C, et al. The microanatomic segregation of selection by apoptosis in the germinal center. Science. 2017;358: pubmed publisher
  • flow cytometry; mouse; fig 4e
Tellier J, Shi W, Minnich M, Liao Y, Crawford S, Smyth G, et al. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response. Nat Immunol. 2016;17:323-30 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, et al. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice. Nat Med. 2016;22:183-93 pubmed publisher
  • flow cytometry; mouse
Jacque E, Schweighoffer E, Tybulewicz V, Ley S. BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J Exp Med. 2015;212:883-92 pubmed publisher
Weng Q, Hu F, Zhang M, Dong Y, Lv C, Wang Y, et al. A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regen (Lond). 2018;7:7-15 pubmed publisher
Stark A, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, et al. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nat Commun. 2018;9:3174 pubmed publisher
Wang X, Zhang Y, Wang Z, Liu X, Zhu G, Han G, et al. Anti?IL?39 (IL?23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus?like mice. Mol Med Rep. 2017;: pubmed publisher
Forster M, Farrington K, Petrov J, Belle J, Mindt B, Witalis M, et al. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response. J Leukoc Biol. 2017;101:643-654 pubmed publisher
Ikawa T, Masuda K, Endo T, Endo M, Isono K, Koseki Y, et al. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev. 2016;30:2475-2485 pubmed
Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
Cheong T, Compagno M, Chiarle R. Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Nat Commun. 2016;7:10934 pubmed publisher
Harmon D, Srikakulapu P, Kaplan J, Oldham S, McSkimming C, Garmey J, et al. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016;36:682-91 pubmed publisher
Yabas M, Jing W, Shafik S, Bröer S, Enders A. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS ONE. 2016;11:e0146774 pubmed publisher
Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, et al. Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A. 2016;113:1256-60 pubmed publisher
Lobo P, Schlegel K, Bajwa A, Huang L, Kurmaeva E, Wang B, et al. Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. J Immunol. 2015;195:5215-26 pubmed publisher
Vuyyuru R, Shen S, Manser T. Testing the role of the Fc?RIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response. Immun Inflamm Dis. 2015;3:247-64 pubmed publisher
Miosge L, Field M, Sontani Y, Cho V, Johnson S, Palkova A, et al. Comparison of predicted and actual consequences of missense mutations. Proc Natl Acad Sci U S A. 2015;112:E5189-98 pubmed publisher
Weindel C, Richey L, Bolland S, Mehta A, Kearney J, Huber B. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy. 2015;11:1010-24 pubmed publisher
Kuzin I, Bouta E, Schwarz E, Bottaro A. TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes. Cell Immunol. 2015;296:133-7 pubmed publisher
Walsh N, Waters L, Fowler J, Lin M, Cunningham C, Brooks D, et al. LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation. EMBO Rep. 2015;16:753-68 pubmed publisher
Cho J, Seo J, Lim C, Yang L, Shiratsuchi T, Lee M, et al. Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015;22:1437-50 pubmed publisher
Tusi B, Deng C, Salz T, Zeumer L, Li Y, So C, et al. Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement. FASEB J. 2015;29:1505-15 pubmed publisher
Kong G, Wunderlich M, Yang D, Ranheim E, Young K, Wang J, et al. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J Clin Invest. 2014;124:2762-73 pubmed publisher
Rouaud P, Saintamand A, Saad F, Carrion C, Lecardeur S, Cogne M, et al. Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region. J Exp Med. 2014;211:975-85 pubmed publisher
Sindhava V, Scholz J, Stohl W, Cancro M. APRIL mediates peritoneal B-1 cell homeostasis. Immunol Lett. 2014;160:120-7 pubmed publisher
Olive V, SABIO E, Bennett M, De Jong C, Biton A, McGann J, et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. elife. 2013;2:e00822 pubmed publisher
Timblin G, Schlissel M. Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development. J Immunol. 2013;191:4676-87 pubmed publisher
Lindner J, Wong C, Möller A, Nielsen P. A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1. Mol Cell Biol. 2013;33:4628-40 pubmed publisher
Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
Torrado E, Fountain J, Robinson R, Martino C, Pearl J, Rangel Moreno J, et al. Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse. PLoS ONE. 2013;8:e61681 pubmed publisher
Bai X, Trowbridge J, Riley E, Lee J, DiBiase A, KAARTINEN V, et al. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013;373:422-30 pubmed publisher
Yu M, Chen Y, He Y, Podd A, Fu G, Wright J, et al. Critical role of B cell lymphoma 10 in BAFF-regulated NF-?B activation and survival of anergic B cells. J Immunol. 2012;189:5185-93 pubmed publisher
Ramon S, Bancos S, Thatcher T, Murant T, Moshkani S, Sahler J, et al. Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response. J Immunol. 2012;189:4740-7 pubmed publisher
Jeelall Y, Wang J, Law H, Domaschenz H, Fung H, Kallies A, et al. Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production. J Exp Med. 2012;209:1907-17 pubmed publisher
Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, et al. PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ. 2012;19:1722-32 pubmed publisher
Rayamajhi M, Delgado C, Condon T, Riches D, Lenz L. Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. Mucosal Immunol. 2012;5:444-54 pubmed publisher
Perlot T, Penninger J. Development and function of murine B cells lacking RANK. J Immunol. 2012;188:1201-5 pubmed publisher
Horikawa M, Minard Colin V, Matsushita T, Tedder T. Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest. 2011;121:4268-80 pubmed publisher
Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A. Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis. PLoS ONE. 2011;6:e18051 pubmed publisher
Wuerzberger Davis S, Chen Y, Yang D, Kearns J, Bates P, Lynch C, et al. Nuclear export of the NF-?B inhibitor I?B? is required for proper B cell and secondary lymphoid tissue formation. Immunity. 2011;34:188-200 pubmed publisher
Sloan R, Kuhl B, Donahue D, Roland A, Bar Magen T, Wainberg M. Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef. J Virol. 2011;85:2828-36 pubmed publisher
Smith S, Haas K, Poe J, Yanaba K, Ward C, Migone T, et al. B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. Int Immunol. 2010;22:681-91 pubmed publisher
Olive V, Bennett M, Walker J, Ma C, Jiang I, Cordon Cardo C, et al. miR-19 is a key oncogenic component of mir-17-92. Genes Dev. 2009;23:2839-49 pubmed publisher
Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, et al. Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood. 2010;115:995-1005 pubmed publisher
Chan A, Jensen K, Skokos D, Doty S, Lederman H, Kaplan R, et al. Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. PLoS ONE. 2009;4:e7955 pubmed publisher
Schuman J, Chen Y, Podd A, Yu M, Liu H, Wen R, et al. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood. 2009;113:4566-74 pubmed publisher
Yanaba K, Bouaziz J, Haas K, Poe J, Fujimoto M, Tedder T. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28:639-50 pubmed publisher
Bai L, Chen Y, He Y, Dai X, Lin X, Wen R, et al. Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. Mol Cell Biol. 2007;27:5957-67 pubmed
product information
Product Type :
Antibody
Product Name :
IgM Monoclonal Antibody (II/41), eBioscience™
Catalog # :
14-5790-82
Quantity :
100µg
Price :
US 108
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
ELISA: Assay-Dependent, Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent
Species :
Mouse
Clone :
II/41
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
IgM is expressed intracellularly, during early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-Dependent, Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent
Aliases :
AGM1; AI326478; Igh6; Igh-6; Ighm; Igh-M; IgM; immunoglobulin heavy chain 6; immunoglobulin heavy constant mu; MU; muH; RGD1359202; VH
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA