Aiolos Monoclonal Antibody (8B2), eBioscience | Invitrogen 14-5789-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Aiolos Monoclonal Antibody (8B2), eBioscience

catalog :

14-5789-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8B2

The same clone is also sold as:

BioLegend: 653203, 653204, 653202, 653205, 653201, 653206

reactivity :

mouse

application :

western blot

citations: 10

Reference
Lazarian G, Yin S, ten Hacken E, Sewastianik T, Uduman M, Font Tello A, et al. A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer Cell. 2021;39:380-393.e8 pubmed publisher
Guichard V, Bonilla N, Durand A, Audemard Verger A, Guilbert T, Martin B, et al. Calcium-mediated shaping of naive CD4 T-cell phenotype and function. elife. 2017;6: pubmed publisher
O Hagan K, Choi J, Pryshchep O, Chernoff J, Phee H. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. J Immunol. 2015;195:1564-77 pubmed publisher
Holmes M, Huntington N, Thong R, Brady J, Hayakawa Y, Andoniou C, et al. Peripheral natural killer cell maturation depends on the transcription factor Aiolos. EMBO J. 2014;33:2721-34 pubmed publisher
Venigalla R, McGuire V, Clarke R, Patterson Kane J, Najafov A, Toth R, et al. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J. 2013;32:1008-22 pubmed publisher
Karnowski A, Cao C, Matthias G, Carotta S, Corcoran L, Martensson I, et al. Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. PLoS ONE. 2008;3:e3568 pubmed publisher
Thompson E, Cobb B, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007;26:335-44 pubmed
Rebollo A, Schmitt C. Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies. Immunol Cell Biol. 2003;81:171-5 pubmed
Romero F, Martinez A C, Camonis J, Rebollo A. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 1999;18:3419-30 pubmed
Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997;16:2004-13 pubmed

product information

Product Type :

Antibody

Product Name :

Aiolos Monoclonal Antibody (8B2), eBioscience

Catalog # :

14-5789-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Western Blot: 5 ug/mL

Species :

Mouse

Clone :

8B2

Isotype :

IgG1, kappa

Storage :

4 C

Description :

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 5 ug/mL

Aliases :

5830411O07Rik; AIO; AIOLOS; IKAROS family zinc finger 3; IKAROS family zinc finger 3 (Aiolos); ikaros family zinc finger protein 3; Ikzf3; Zfpn1a3; zinc finger DNA binding protein Aiolos; zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); Znfn1a3