This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NOTCH1 Monoclonal Antibody (mN1A), eBioscience
catalog :
14-5785-37
quantity :
2 mg
price :
US 1474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
mN1A

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, flow cytometry
citations: 9
Reference
Islam S, Qassem K, Islam S, Parag R, Rahman M, Farhat W, et al. Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma. Cell Death Dis. 2022;13:696 pubmed publisher
Portal C, Wang Z, Scott D, Wolosin J, Iomini C. The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair. Invest Ophthalmol Vis Sci. 2022;63:3 pubmed publisher
Larose H, Prokoph N, Matthews J, Schlederer M, Högler S, Alsulami A, et al. Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target. Haematologica. 2020;: pubmed publisher
Skarmoutsou E, Bevelacqua V, D Amico F, Russo A, Spandidos D, Scalisi A, et al. FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma. Int J Mol Med. 2018;42:392-404 pubmed publisher
Roderick J, González Pérez G, Kuksin C, Dongre A, Roberts E, Srinivasan J, et al. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med. 2013;210:1311-29 pubmed publisher
Tezgel A, González Pérez G, Telfer J, Osborne B, Minter L, Tew G. Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells. Mol Ther. 2013;21:201-9 pubmed publisher
Billiard F, Lobry C, Darrasse Jèze G, Waite J, Liu X, Mouquet H, et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med. 2012;209:1011-28 pubmed publisher
Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, et al. Notch signaling regulates mouse and human Th17 differentiation. J Immunol. 2011;187:692-701 pubmed publisher
Yan H, Blackburn A, McLary S, Tao L, Roberts A, Xavier E, et al. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol. 2010;176:1421-32 pubmed publisher
product information
Product Type :
Antibody
Product Name :
NOTCH1 Monoclonal Antibody (mN1A), eBioscience
Catalog # :
14-5785-37
Quantity :
2 mg
Price :
US 1474.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1 ug/test, Immunohistochemistry: Assay-Dependent, Western Blot: 1:500
Species :
Human, Mouse
Clone :
mN1A
Isotype :
IgG1, kappa
Storage :
4 C
Description :
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Immunohistochemistry: Assay-Dependent, Western Blot: 1:500
Aliases :
9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA