product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FOXP3 Monoclonal Antibody (FJK-16s), eBioscience
catalog :
14-5773-82
quantity :
100 µg
price :
US 374
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
FJK-16s
reactivity :
horses, human, mouse, rat, dogs, bovine, pigs , cat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 1877
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1b
Kim M, Borcherding N, Ahmed K, Voigt A, Vishwakarma A, Kolb R, et al. CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Nat Commun. 2021;12:5764 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...
Liu H, Pedros C, Kong K, Canonigo Balancio A, Xue W, Altman A. Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy. J Immunother Cancer. 2021;9: pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 3d
Pavasutthipaisit S, Stoff M, Ebbecke T, Ciurkiewicz M, Mayer Lambertz S, Stork T, et al. CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination. Int J Mol Sci. 2021;22: pubmed publisher
  • flow cytometry; mouse; 1:40; loading ...; fig 3f
Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, et al. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021;12:3754 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s3b
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  • flow cytometry; mouse; 1:200; fig 2c
Zhang S, Li L, Xie D, Reddy S, Sleasman J, Ma L, et al. Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1. Front Immunol. 2021;12:620437 pubmed publisher
  • flow cytometry; mouse; loading ...
Jhala G, Selck C, Chee J, Kwong C, Pappas E, Thomas H, et al. Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice. Front Immunol. 2021;12:645817 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig 7a
Borges P, Waclawiak I, Georgii J, Fraga Junior V, Barros J, Lemos F, et al. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Front Immunol. 2021;12:651740 pubmed publisher
  • flow cytometry; mouse; loading ...
Nian Y, Iske J, Maenosono R, Minami K, Heinbokel T, Quante M, et al. Targeting age-specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival. Aging Cell. 2021;20:e13299 pubmed publisher
  • flow cytometry; mouse; 1:50; fig s17b
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed publisher
  • flow cytometry; mouse; fig 2b
Zhao L, Hu S, Davila M, Yang J, Lin Y, Albanese J, et al. Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunol. 2021;14:420-430 pubmed publisher
  • flow cytometry; horses; 1:10; loading ...; fig 1
Piszczatowska K, Przybylska D, Sikora E, Mosieniak G. Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells. Antioxidants (Basel). 2020;9: pubmed publisher
  • flow cytometry; horses; 1:10; loading ...; fig 1
Yasuoka M, Monteiro B, Fantinato Neto P, Paiano R, Fantoni D, Otsuki D, et al. Transient Pulmonary Artery Hypertension in Holstein Neonate Calves. Animals (Basel). 2020;10: pubmed publisher
  • flow cytometry; horses; 1:10; loading ...; fig 1
Zhang Z, Zheng Q, Liu Y, Sun L, Han P, Wang R, et al. Human CD133-positive hematopoietic progenitor cells enhance the malignancy of breast cancer cells. BMC Cancer. 2020;20:1158 pubmed publisher
  • flow cytometry; horses; 1:10; loading ...; fig 1
Witkowska Piłaszewicz O, Pingwara R, Winnicka A. The Effect of Physical Training on Peripheral Blood Mononuclear Cell Ex Vivo Proliferation, Differentiation, Activity, and Reactive Oxygen Species Production in Racehorses. Antioxidants (Basel). 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s6-2
Jensen I, Jensen S, Sjaastad F, Gibson Corley K, Dileepan T, Griffith T, et al. Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...
Fernandes R, Li C, Wang G, Yang X, Savvides C, Glassman C, et al. Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody K, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6:eaba4353 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 2d
  • flow cytometry; mouse; 1:100; loading ...; fig 2j
Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5c, 5d
Zhang S, Liang W, Luo L, Sun S, Wang F. The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology. BMC Biol. 2020;18:29 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7
Lawenius L, Scheffler J, Gustafsson K, Henning P, Nilsson K, Colldén H, et al. Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss. Am J Physiol Endocrinol Metab. 2020;318:E480-E491 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6s1
Canel M, Taggart D, Sims A, Lonergan D, Waizenegger I, Serrels A. T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1, 2, 3d
Raphael I, Gomez Rivera F, Raphael R, Robinson R, Nalawade S, Forsthuber T. TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells. JCI Insight. 2019;4: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4p
  • flow cytometry; mouse; 1:100; loading ...; fig 4b
Li A, Herbst R, Canner D, Schenkel J, Smith O, Kim J, et al. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Rep. 2019;29:2998-3008.e8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2j
Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e8b
Alspach E, Lussier D, Miceli A, Kizhvatov I, DuPage M, Luoma A, et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019;574:696-701 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Wang P, Qi X, Xu G, Liu J, Guo J, Li X, et al. CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY). 2019;11:7402-7415 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4h
Wolf Y, Bartok O, Patkar S, Eli G, Cohen S, Litchfield K, et al. UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. Cell. 2019;179:219-235.e21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2a
Sorrentino C, Yin Z, Ciummo S, Lanuti P, Lu L, Marchisio M, et al. Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival. J Immunother Cancer. 2019;7:201 pubmed publisher
  • flow cytometry; mouse; 1:250; loading ...; fig 3e, 3f, s6c, s6d
Ansaldo E, Slayden L, Ching K, Koch M, Wolf N, Plichta D, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019;364:1179-1184 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig 2f
Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, et al. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019;10:2352 pubmed publisher
  • flow cytometry; mouse; loading ...
Di Pilato M, Kim E, Cadilha B, Prüßmann J, Nasrallah M, Seruggia D, et al. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019;570:112-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Sharma N, Vacher J, Allison J. TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion. Proc Natl Acad Sci U S A. 2019;116:10453-10462 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7a
Kawalkowska J, Ogbechi J, Venables P, Williams R. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs. Sci Adv. 2019;5:eaaw5422 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3h
Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
  • flow cytometry; mouse; loading ...; fig e1b, e1c, e1d
Silva D, Yu S, Ulge U, Spangler J, Jude K, Labao Almeida C, et al. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 2019;565:186-191 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig s1b
Aarts S, Seijkens T, Kusters P, Van Tiel C, Reiche M, den Toom M, et al. Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis. J Pathol. 2019;247:471-480 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s8a
Dong S, Harrington B, Hu E, Greene J, Lehman A, Tran M, et al. PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression. J Clin Invest. 2019;129:122-136 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c, 4d
Maseda D, Banerjee A, Johnson E, Washington M, Kim H, Lau K, et al. mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation. Front Immunol. 2018;9:2954 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2d
Ding L, Kim H, Wang Q, Kearns M, Jiang T, Ohlson C, et al. PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Rep. 2018;25:2972-2980.e5 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3g
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b, s5b
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a, 2c
Atretkhany K, Mufazalov I, Dunst J, Kuchmiy A, Gogoleva V, Andruszewski D, et al. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018;115:13051-13056 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s4c
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Humblet Baron S, Barber J, Roca C, Lenaerts A, Koni P, Liston A. Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells. Blood. 2018;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2e
Mollaoglu G, Jones A, Wait S, Mukhopadhyay A, Jeong S, Arya R, et al. The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018;49:764-779.e9 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s10a
Deason K, Troutman T, Jain A, Challa D, Mandraju R, Brewer T, et al. BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation. J Exp Med. 2018;215:2413-2428 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6e
Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen H, Bastian D, Zhang M, et al. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018;128:2787-2801 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5c
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots G, et al. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018;9:714 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Tanaka S, Pfleger C, Lai J, Roan F, Sun S, Ziegler S. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23:796-807 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
Prado C, Gaiazzi M, Gonzalez H, Ugalde V, Figueroa A, Osorio Barrios F, et al. Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:571 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1f
Gaddis D, Padgett L, Wu R, McSkimming C, Romines V, Taylor A, et al. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018;9:1095 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8
Kornete M, Marone R, Jeker L. Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. J Immunol. 2018;200:2489-2501 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 9c
Kim I, Kim K, Lee E, Oh D, Park C, Park S, et al. Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. J Exp Med. 2018;215:963-983 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5a
Kotov D, Kotov J, Goldberg M, Jenkins M. Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. J Immunol. 2018;200:2004-2012 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Perry C, Muñoz Rojas A, Meeth K, Kellman L, Amezquita R, Thakral D, et al. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018;215:877-893 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5f
Seki A, Rutz S. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells. J Exp Med. 2018;215:985-997 pubmed publisher
  • flow cytometry; human; 1:100; fig 1a
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4e
Wheeler D, Sariol A, Meyerholz D, Perlman S. Microglia are required for protection against lethal coronavirus encephalitis in mice. J Clin Invest. 2018;128:931-943 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Fontaine M, Vogel I, Van Eycke Y, Galuppo A, Ajouaou Y, Decaestecker C, et al. Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells. EMBO J. 2018;37:398-412 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 5b
Guimarães G, Gomes M, Campos P, Marinho F, de Assis N, Silveira T, et al. Immunoproteasome Subunits Are Required for CD8+ T Cell Function and Host Resistance to Brucella abortus Infection in Mice. Infect Immun. 2018;86: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5
Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Burrack A, Malhotra D, Dileepan T, Osum K, Swanson L, Fife B, et al. Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides. J Immunol. 2018;200:477-482 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Maseda D, Johnson E, Nyhoff L, Baron B, Kojima F, Wilhelm A, et al. mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production. J Immunol. 2018;200:725-736 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Mailer R, Gisterå A, Polyzos K, Ketelhuth D, Hansson G. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:15655 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
  • immunohistochemistry; mouse; loading ...; fig 4f
Goel S, Decristo M, Watt A, BrinJones H, Sceneay J, Li B, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017;548:471-475 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, et al. The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun. 2017;8:254 pubmed publisher
  • flow cytometry; rat; loading ...; fig s7
Kyratsous N, Bauer I, Zhang G, Pesic M, Bartholomäus I, Mues M, et al. Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proc Natl Acad Sci U S A. 2017;114:E6381-E6389 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Billerbeck E, Wolfisberg R, Fahnøe U, Xiao J, Quirk C, Luna J, et al. Mouse models of acute and chronic hepacivirus infection. Science. 2017;357:204-208 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Sitrin J, Suto E, Wuster A, Eastham Anderson J, Kim J, Austin C, et al. The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice. J Immunol. 2017;199:1238-1249 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6d
Seifert H, Benedek G, Liang J, Nguyen H, Kent G, Vandenbark A, et al. Sex differences in regulatory cells in experimental stroke. Cell Immunol. 2017;318:49-54 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Xie M, Koh B, Hollister K, Wu H, Sun J, Kaplan M, et al. Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. Eur J Immunol. 2017;47:1136-1141 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
  • flow cytometry; human; loading ...; fig 2d
Li C, Leng Y, Zhao B, Gao C, Du F, Jin N, et al. Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases. Stem Cells. 2017;35:1719-1732 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Burton O, Tamayo J, Stranks A, Koleoglou K, Oettgen H. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141:189-201.e3 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7b
Daley D, Mani V, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214:1711-1724 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1c
  • flow cytometry; mouse; loading ...; fig 2d
Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Immunology. 2017;152:65-73 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5i
Angelin A, Gil de Gómez L, Dahiya S, Jiao J, Guo L, Levine M, et al. Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab. 2017;25:1282-1293.e7 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7d
Garg G, Nikolouli E, Hardtke Wolenski M, Toker A, Ohkura N, Beckstette M, et al. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. 2017;8:35542-35557 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Zemmour D, Pratama A, Loughhead S, Mathis D, Benoist C. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proc Natl Acad Sci U S A. 2017;114:E3472-E3480 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1h
Bouziat R, Hinterleitner R, Brown J, Stencel Baerenwald J, Ikizler M, Mayassi T, et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017;356:44-50 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5d
Bruce D, Stefanski H, Vincent B, Dant T, Reisdorf S, Bommiasamy H, et al. Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease. J Clin Invest. 2017;127:1813-1825 pubmed publisher
  • flow cytometry; mouse; fig 1e
  • western blot; mouse
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:800; loading ...; fig st7
  • immunohistochemistry - paraffin section; mouse; 1:800; loading ...; fig st7
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 6a
  • flow cytometry; mouse
Ramjee V, Li D, Manderfield L, Liu F, Engleka K, Aghajanian H, et al. Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. J Clin Invest. 2017;127:899-911 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Asano T, Meguri Y, Yoshioka T, Kishi Y, Iwamoto M, Nakamura M, et al. PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy. Blood. 2017;129:2186-2197 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Goverse G, Molenaar R, Macia L, Tan J, Erkelens M, Konijn T, et al. Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. J Immunol. 2017;198:2172-2181 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4f
Mizutani H, Tamagawa Mineoka R, Minami Y, Yagita K, Katoh N. Constant light exposure impairs immune tolerance development in mice. J Dermatol Sci. 2017;86:63-70 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1k
Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, et al. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017;214:209-226 pubmed publisher
  • flow cytometry; rat; loading ...; fig 1f
Tuncel J, Haag S, Holmdahl R. MHC class II alleles associated with Th1 rather than Th17 type immunity drive the onset of early arthritis in a rat model of rheumatoid arthritis. Eur J Immunol. 2017;47:563-574 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
Hashimoto Hill S, Friesen L, Kim M, Kim C. Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7. Mucosal Immunol. 2017;10:912-923 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Yokota Nakatsuma A, Ohoka Y, Takeuchi H, Song S, Iwata M. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties. Sci Rep. 2016;6:37914 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3f
Hammer A, Yang G, Friedrich J, Kovacs A, Lee D, Grave K, et al. Role of the receptor Mas in macrophage-mediated inflammation in vivo. Proc Natl Acad Sci U S A. 2016;113:14109-14114 pubmed
  • flow cytometry; mouse; loading ...; fig 2c
Escalante N, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker C, et al. The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility. J Exp Med. 2016;213:2841-2850 pubmed
  • flow cytometry; mouse; fig 4d
Cummings R, Barbet G, Bongers G, Hartmann B, Gettler K, Muniz L, et al. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature. 2016;539:565-569 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest. 2016;126:4626-4639 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
Kwong Chung C, Ronchi F, Geuking M. Detrimental effect of systemic antimicrobial CD4+ T-cell reactivity on gut epithelial integrity. Immunology. 2017;150:221-235 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2e
Massaad M, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, et al. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016;126:4219-4236 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
Klotz L, Kuzmanov I, Hucke S, Gross C, Posevitz V, Dreykluft A, et al. B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A. 2016;113:E6182-E6191 pubmed
  • flow cytometry; mouse; loading ...; fig 3d
Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed
  • flow cytometry; mouse; loading ...; fig 6a
Lexmond W, Goettel J, Lyons J, Jacobse J, Deken M, Lawrence M, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016;126:4030-4044 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Butcher M, Filipowicz A, Waseem T, McGary C, Crow K, Magilnick N, et al. Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFN?+ Th1/Tregs. Circ Res. 2016;119:1190-1203 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 11C
  • flow cytometry; mouse; loading ...; fig 12
Uhde A, Herder V, Akram Khan M, Ciurkiewicz M, Schaudien D, Teich R, et al. Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice. PLoS ONE. 2016;11:e0161883 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, et al. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med. 2016;213:1881-900 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta N, et al. Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection. J Exp Med. 2016;213:1695-703 pubmed publisher
  • flow cytometry; mouse; fig 2
Pizzolla A, Oh D, Luong S, Prickett S, Henstridge D, Febbraio M, et al. High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance. PLoS ONE. 2016;11:e0160407 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s7
Ferreirinha P, Pérez Cabezas B, Correia A, Miyazawa B, França A, Carvalhais V, et al. Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their In Vivo Proinflammatory Effect. Infect Immun. 2016;84:2933-43 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Biton J, Khaleghparast Athari S, Thiolat A, Santinon F, Lemeiter D, Hervé R, et al. In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis. J Immunol. 2016;197:1708-19 pubmed publisher
  • flow cytometry; mouse; fig 5
Seifert A, Zeng S, Zhang J, Kim T, Cohen N, Beckman M, et al. PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors. Clin Cancer Res. 2017;23:454-465 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4
Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Lim J, Im K, Lee E, Kim N, Nam Y, Jeon Y, et al. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis. Sci Rep. 2016;6:26851 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1
Chu H, Khosravi A, Kusumawardhani I, Kwon A, Vasconcelos A, Cunha L, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016;352:1116-20 pubmed publisher
  • flow cytometry; mouse; fig s8
Brandstätter O, Schanz O, Vorac J, König J, Mori T, Maruyama T, et al. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016;6:26091 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1f
Holmkvist P, Pool L, Hägerbrand K, Agace W, Rivollier A. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness. Eur J Immunol. 2016;46:1371-82 pubmed publisher
  • flow cytometry; mouse; fig s1
Sim C, Cho Y, Kim B, Baek I, Kim Y, Lee M. 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Cancer Immunol Immunother. 2016;65:663-75 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4h
Mathewson N, Jenq R, Mathew A, Koenigsknecht M, Hanash A, Toubai T, et al. Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol. 2016;17:505-513 pubmed publisher
  • flow cytometry; mouse; fig s5c
Gomez de Agüero M, Ganal Vonarburg S, Fuhrer T, Rupp S, Uchimura Y, Li H, et al. The maternal microbiota drives early postnatal innate immune development. Science. 2016;351:1296-302 pubmed publisher
  • flow cytometry; mouse; fig 2
Kabat A, Harrison O, Riffelmacher T, Moghaddam A, Pearson C, Laing A, et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. elife. 2016;5:e12444 pubmed publisher
  • flow cytometry; mouse; fig 1
Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4g
Xiong Y, Ahmad S, Iwami D, Brinkman C, Bromberg J. T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function. J Immunol. 2016;196:2526-40 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7a
Lin C, Bradstreet T, Schwarzkopf E, Jarjour N, Chou C, Archambault A, et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016;213:251-71 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 1
Aloulou M, Carr E, Gador M, Bignon A, Liblau R, Fazilleau N, et al. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016;7:10579 pubmed publisher
  • flow cytometry; mouse; fig 3
  • immunocytochemistry; mouse; 1:150
Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher
  • flow cytometry; mouse; fig 3
Kuipers H, Rieck M, Gurevich I, Nagy N, Butte M, Negrin R, et al. Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. Proc Natl Acad Sci U S A. 2016;113:1339-44 pubmed publisher
  • flow cytometry; mouse; fig 4, 5
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Onodera T, Fukuhara A, Jang M, Shin J, Aoi K, Kikuta J, et al. Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells. Sci Rep. 2015;5:16801 pubmed publisher
  • flow cytometry; mouse; fig s4
Kim J, Phan T, Nguyen V, Dinh Vu H, Zheng J, Yun M, et al. Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β. Theranostics. 2015;5:1328-42 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015;16:1235-44 pubmed publisher
  • flow cytometry; mouse; 1:200; fig 1
Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher
  • flow cytometry; mouse; fig 3
Poncini C, Ilarregui J, Batalla E, Engels S, Cerliani J, Cucher M, et al. Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms. J Immunol. 2015;195:3311-24 pubmed publisher
  • immunohistochemistry - paraffin section; bovine; 1:100; loading ...; fig 1h
Romero Palomo F, Risalde M, Gómez Villamandos J. Immunopathologic Changes in the Thymus of Calves Pre-infected with BVDV and Challenged with BHV-1. Transbound Emerg Dis. 2017;64:574-584 pubmed publisher
  • flow cytometry; mouse
Xin L, Jiang T, Kinder J, Ertelt J, Way S. Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice. Aging Cell. 2015;14:1122-6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Ngiow S, Young A, Jacquelot N, Yamazaki T, Enot D, Zitvogel L, et al. A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Cancer Res. 2015;75:3800-11 pubmed publisher
  • flow cytometry; mouse
Redpath S, Van Der Werf N, MacDonald A, Maizels R, Taylor M. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun. 2015;83:3881-9 pubmed publisher
  • flow cytometry; mouse
Evonuk K, Baker B, Doyle R, Moseley C, Sestero C, Johnston B, et al. Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination. J Immunol. 2015;195:450-463 pubmed publisher
  • flow cytometry; mouse; fig 1
Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, et al. DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Immunity. 2015;42:1143-58 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig s8
Chen H, Sun J, Huang Z, Hou H, Arcilla M, Rakhilin N, et al. Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nat Biotechnol. 2015;33:656-60 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig 4d
Liao J, Ovenell K, Curtis E, Cecil D, Koehnlein M, Rastetter L, et al. Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer. J Immunother Cancer. 2015;3:16 pubmed publisher
  • flow cytometry; mouse; fig 5
Holm J, Sorobetea D, Kiilerich P, Ramayo Caldas Y, Estellé J, Ma T, et al. Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli. PLoS ONE. 2015;10:e0125495 pubmed publisher
  • immunohistochemistry; human; 1:200
Dennis K, Saadalla A, Blatner N, Wang S, Venkateswaran V, Gounari F, et al. T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res. 2015;3:806-14 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6b
  • immunohistochemistry; mouse; loading ...; fig 3b
Lal G, Nakayama Y, Sethi A, Singh A, Burrell B, Kulkarni N, et al. Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance. Transplantation. 2015;99:1817-28 pubmed publisher
  • flow cytometry; mouse; fig 8
Van Den Ham K, Shio M, Rainone A, Fournier S, Krawczyk C, Olivier M. Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis. PLoS ONE. 2015;10:e0118451 pubmed publisher
  • flow cytometry; mouse; fig s4
Wiesner D, Specht C, Lee C, Smith K, Mukaremera L, Lee S, et al. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog. 2015;11:e1004701 pubmed publisher
  • flow cytometry; mouse
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  • western blot; mouse; 1:100; fig 5,6
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed publisher
  • flow cytometry; mouse; fig 1
Buchwald Z, Yang C, Nellore S, Shashkova E, Davis J, Cline A, et al. A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells. J Bone Miner Res. 2015;30:1508-22 pubmed publisher
  • flow cytometry; mouse
Triplett T, Tucker C, Triplett K, Alderman Z, Sun L, Ling L, et al. STAT3 Signaling Is Required for Optimal Regression of Large Established Tumors in Mice Treated with Anti-OX40 and TGFβ Receptor Blockade. Cancer Immunol Res. 2015;3:526-35 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s5
Evans E, Jonason A, Bussler H, Torno S, Veeraraghavan J, Reilly C, et al. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies. Cancer Immunol Res. 2015;3:689-701 pubmed publisher
  • flow cytometry; mouse; fig 6
Zhang Y, Wu B, Metelli A, Thaxton J, Hong F, Rachidi S, et al. GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest. 2015;125:859-69 pubmed publisher
  • flow cytometry; mouse; fig s2
Clouthier D, Zhou A, Wortzman M, Luft O, Levy G, Watts T. GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection. PLoS Pathog. 2015;11:e1004517 pubmed publisher
  • flow cytometry; mouse
Singh K, Hjort M, Thorvaldson L, Sandler S. Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice. Sci Rep. 2015;5:7767 pubmed publisher
  • flow cytometry; human; fig 5
Hannani D, Vétizou M, Enot D, Rusakiewicz S, Chaput N, Klatzmann D, et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res. 2015;25:208-24 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 2
  • flow cytometry; mouse
Teixeira L, Moreira J, Melo J, Bezerra F, Marques R, Ferreirinha P, et al. Immune response in the adipose tissue of lean mice infected with the protozoan parasite Neospora caninum. Immunology. 2015;145:242-57 pubmed publisher
  • flow cytometry; mouse; tbl 1
Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, et al. Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. J Neuroinflammation. 2015;12:208 pubmed publisher
  • flow cytometry; mouse; fig s5
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher
  • flow cytometry; mouse; fig 2
Krishnamoorthy N, Burkett P, Dalli J, Abdulnour R, Colas R, Ramon S, et al. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015;194:863-7 pubmed publisher
  • flow cytometry; mouse
Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, et al. Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. PLoS ONE. 2014;9:e115198 pubmed publisher
  • flow cytometry; mouse
Harmon E, Fronhofer V, Keller R, Feustel P, Zhu X, Xu H, et al. Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques. J Am Heart Assoc. 2014;3:e001232 pubmed publisher
  • flow cytometry; mouse
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
  • flow cytometry; pigs
Gerner W, Talker S, Koinig H, Sedlak C, Mair K, Saalmüller A. Phenotypic and functional differentiation of porcine αβ T cells: current knowledge and available tools. Mol Immunol. 2015;66:3-13 pubmed publisher
  • immunohistochemistry; mouse; 1:25
Lees J, Duffy S, Perera C, Moalem Taylor G. Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury. Cytokine. 2015;71:207-14 pubmed publisher
  • flow cytometry; mouse; fig 4
Hou J, Zhang Q, Fujino M, Cai S, Ito H, Takahashi K, et al. 5-Aminolevulinic acid with ferrous iron induces permanent cardiac allograft acceptance in mice via induction of regulatory cells. J Heart Lung Transplant. 2015;34:254-63 pubmed publisher
  • flow cytometry; mouse
Peters A, Burkett P, Sobel R, Buckley C, Watson S, Bettelli E, et al. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2015;125:129-40 pubmed publisher
  • flow cytometry; mouse; fig 2
Uchiyama M, Jin X, Yin E, Shimokawa T, Niimi M. Treadmill exercise induces murine cardiac allograft survival and generates regulatory T cell. Transpl Int. 2015;28:352-62 pubmed publisher
  • flow cytometry; mouse; fig 7
  • immunohistochemistry; mouse; fig 7
Donaldson D, Bradford B, Artis D, Mabbott N. Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23. Mucosal Immunol. 2015;8:582-95 pubmed publisher
  • flow cytometry; mouse; 1:100
Burton B, Britton G, Fang H, Verhagen J, Smithers B, Sabatos Peyton C, et al. Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nat Commun. 2014;5:4741 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 3
  • flow cytometry; mouse; fig 5
Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K, Matsushita T. B cells promote tumor immunity against B16F10 melanoma. Am J Pathol. 2014;184:3120-9 pubmed publisher
  • flow cytometry; mouse
Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, et al. Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo. Immunobiology. 2015;220:270-9 pubmed publisher
  • flow cytometry; mouse
Penaloza MacMaster P, Kamphorst A, Wieland A, Araki K, Iyer S, West E, et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med. 2014;211:1905-18 pubmed publisher
  • flow cytometry; mouse; fig 4
Ishihara M, Seo N, Mitsui J, Muraoka D, Tanaka M, Mineno J, et al. Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor. PLoS ONE. 2014;9:e104669 pubmed publisher
  • flow cytometry; mouse
Denton A, Roberts E, Linterman M, Fearon D. Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proc Natl Acad Sci U S A. 2014;111:12139-44 pubmed publisher
  • flow cytometry; human
Zhu Y, Knolhoff B, Meyer M, Nywening T, West B, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74:5057-69 pubmed publisher
  • flow cytometry; mouse
Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning C, et al. Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection. Nanomedicine. 2014;10:1787-98 pubmed publisher
  • flow cytometry; mouse
Vogelzang A, Perdomo C, Zedler U, Kuhlmann S, Hurwitz R, Gengenbacher M, et al. Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ?ureC::hly vaccine's superior protection against tuberculosis. J Infect Dis. 2014;210:1928-37 pubmed publisher
  • flow cytometry; mouse
Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, et al. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res. 2014;74:4258-69 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4
Nandi B, Pai C, Huang Q, Prabhala R, Munshi N, Gold J. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE. 2014;9:e97566 pubmed publisher
  • flow cytometry; mouse
Smolarchuk C, Zhu L, Chan W, Anderson C. T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol. 2014;44:2263-73 pubmed publisher
  • flow cytometry; mouse
Pick J, Arra A, Lingel H, Hegel J, Huber M, Nishanth G, et al. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol. 2014;44:2139-52 pubmed publisher
  • immunohistochemistry; dogs; 1:400
Rossi G, Pengo G, Caldin M, Palumbo Piccionello A, Steiner J, Cohen N, et al. Comparison of microbiological, histological, and immunomodulatory parameters in response to treatment with either combination therapy with prednisone and metronidazole or probiotic VSL#3 strains in dogs with idiopathic inflammatory bowel disease. PLoS ONE. 2014;9:e94699 pubmed publisher
  • flow cytometry; mouse
Cochain C, Chaudhari S, Koch M, Wiendl H, Eckstein H, Zernecke A. Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS ONE. 2014;9:e93280 pubmed publisher
  • flow cytometry; mouse; fig 4
Samuelson E, Laird R, Papillion A, Tatum A, Princiotta M, Hayes S. Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice. PLoS ONE. 2014;9:e92054 pubmed publisher
  • flow cytometry; mouse; 1:100
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
  • flow cytometry; mouse
Mercadante A, Perobelli S, Alves A, Gonçalves Silva T, Mello W, Gomes Santos A, et al. Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance. J Immunol. 2014;192:1928-37 pubmed publisher
  • flow cytometry; mouse
Joedicke J, Dietze K, Zelinskyy G, Dittmer U. The phenotype and activation status of regulatory T cells during Friend retrovirus infection. Virol Sin. 2014;29:48-60 pubmed publisher
  • flow cytometry; mouse
Hu Y, Xiao H, Shi T, Oppenheim J, Chen X. Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4? Foxp3? regulatory T cells. Immunology. 2014;142:193-201 pubmed publisher
  • flow cytometry; mouse
Saligrama N, Case L, Krementsov D, Teuscher C. Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J. 2014;28:1898-909 pubmed publisher
  • flow cytometry; mouse
Chatterjee S, Eby J, Al Khami A, Soloshchenko M, Kang H, Kaur N, et al. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol. 2014;134:1285-1294 pubmed publisher
  • flow cytometry; mouse
Cavnar M, Zeng S, Kim T, Sorenson E, Ocuin L, Balachandran V, et al. KIT oncogene inhibition drives intratumoral macrophage M2 polarization. J Exp Med. 2013;210:2873-86 pubmed publisher
  • flow cytometry; mouse
Murphy K, Erickson J, Johnson C, Seiler C, Bedi J, Hu P, et al. CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol. 2014;192:224-33 pubmed publisher
  • flow cytometry; mouse
  • immunohistochemistry; mouse; fig 2
Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein C, et al. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE. 2013;8:e75737 pubmed publisher
  • flow cytometry; mouse; fig s2
Yockey L, Demehri S, Turkoz M, Turkoz A, Ahern P, Jassim O, et al. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013;133:2714-2721 pubmed publisher
  • flow cytometry; mouse; fig s3
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
  • flow cytometry; mouse
Billich A, Baumruker T, Beerli C, Bigaud M, Bruns C, Calzascia T, et al. Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS ONE. 2013;8:e59630 pubmed publisher
  • flow cytometry; mouse; fig 6
Redpath S, Van Der Werf N, Cervera A, MacDonald A, Gray D, Maizels R, et al. ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol. 2013;43:705-15 pubmed publisher
  • flow cytometry; mouse; fig s4
Khan A, Fu H, Tan L, Harper J, Beutelspacher S, Larkin D, et al. Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition. Eur J Immunol. 2013;43:734-46 pubmed publisher
  • immunohistochemistry; mouse; fig 6
Weiss J, Bilate A, Gobert M, Ding Y, Curotto de Lafaille M, Parkhurst C, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med. 2012;209:1723-42, S1 pubmed
  • flow cytometry; mouse; fig 7
Hwang S, Song K, Lesourne R, Lee J, Pinkhasov J, Li L, et al. Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med. 2012;209:1781-95 pubmed
  • flow cytometry; mouse
Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice. Evid Based Complement Alternat Med. 2012;2012:689810 pubmed publisher
  • flow cytometry; mouse
Golias J, Schwarzer M, Wallner M, Kverka M, Kozakova H, Srůtková D, et al. Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. PLoS ONE. 2012;7:e37156 pubmed publisher
  • flow cytometry; mouse; fig 6
Feng T, Cong Y, Alexander K, Elson C. Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells. PLoS ONE. 2012;7:e35918 pubmed publisher
  • flow cytometry; mouse; fig 2
Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg. 2012;7:26 pubmed publisher
  • flow cytometry; mouse
Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney N, Schuijs M, et al. IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS ONE. 2012;7:e32371 pubmed publisher
  • flow cytometry; mouse
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
  • flow cytometry; mouse
Wollenberg I, Agua Doce A, Hernandez A, Almeida C, Oliveira V, Faro J, et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol. 2011;187:4553-60 pubmed publisher
  • flow cytometry; mouse
Qian B, Li J, Zhang H, Kitamura T, Zhang J, Campion L, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222-5 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 1
Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, et al. Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice. PLoS ONE. 2011;6:e19495 pubmed publisher
  • flow cytometry; mouse; fig 1
Goldstein J, Balderas R, Marodon G. Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus. PLoS ONE. 2011;6:e19038 pubmed publisher
  • flow cytometry; mouse; fig 5, 6
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med. 2010;207:2561-8 pubmed publisher
  • flow cytometry; mouse; fig 2
Lin P, Sun L, Thibodeaux S, Ludwig S, Vadlamudi R, Hurez V, et al. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol. 2010;185:2747-53 pubmed publisher
  • flow cytometry; mouse; fig 1
Cai S, Cao X, Hassan A, Fehniger T, Ley T. Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. Blood. 2010;115:1669-77 pubmed publisher
  • flow cytometry; mouse
Blache C, Adriouch S, Calbo S, Drouot L, Dulauroy S, Arnoult C, et al. Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells. J Immunol. 2009;183:4182-6 pubmed publisher
  • flow cytometry; mouse
Zelinskyy G, Dietze K, Hüsecken Y, Schimmer S, Nair S, Werner T, et al. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood. 2009;114:3199-207 pubmed publisher
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Houot R, Goldstein M, Kohrt H, Myklebust J, Alizadeh A, Lin J, et al. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood. 2009;114:3431-8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6
  • flow cytometry; mouse; fig 5
Ellestad K, Tsutsui S, Noorbakhsh F, Warren K, Yong V, Pittman Q, et al. Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells. J Immunol. 2009;183:298-309 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Abboud G, Staumont Sallé D, Kanda A, Roumier T, Deruytter N, Lavogiez C, et al. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol. 2009;182:6517-26 pubmed publisher
  • flow cytometry; mouse; fig 5c
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
  • flow cytometry; mouse
Sato K, Eizumi K, Fukaya T, Fujita S, Sato Y, Takagi H, et al. Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood. 2009;113:4780-9 pubmed publisher
  • flow cytometry; mouse; fig 8
Ribeiro de Almeida C, Heath H, Krpic S, Dingjan G, van Hamburg J, Bergen I, et al. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol. 2009;182:999-1010 pubmed
  • flow cytometry; mouse
Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, et al. Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation. J Immunol. 2008;181:6889-97 pubmed
  • flow cytometry; mouse
Casiraghi F, Azzollini N, Cassis P, Imberti B, Morigi M, Cugini D, et al. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol. 2008;181:3933-46 pubmed
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Reinwald S, Wiethe C, Westendorf A, Breloer M, Probst Kepper M, Fleischer B, et al. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. J Immunol. 2008;180:5890-7 pubmed
  • flow cytometry; mouse; fig 1d
Bommireddy R, Babcock G, Singh R, Doetschman T. TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function. Clin Immunol. 2008;127:206-13 pubmed publisher
  • flow cytometry; mouse; fig 5
Barron L, Knoechel B, Lohr J, Abbas A. Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance. J Immunol. 2008;180:2762-6 pubmed
  • flow cytometry; mouse
Rana S, Byrne S, MacDonald L, Chan C, Halliday G. Ultraviolet B suppresses immunity by inhibiting effector and memory T cells. Am J Pathol. 2008;172:993-1004 pubmed publisher
  • flow cytometry; mouse; fig 4
Ahonen C, Wasiuk A, Fuse S, Turk M, Ernstoff M, Suriawinata A, et al. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008;111:3116-25 pubmed publisher
  • flow cytometry; mouse
Venanzi E, Gray D, Benoist C, Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol. 2007;179:5693-700 pubmed
  • flow cytometry; mouse; fig 3
Cambos M, Belanger B, Jacques A, Roulet A, Scorza T. Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. Int J Parasitol. 2008;38:229-38 pubmed
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Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
  • flow cytometry; mouse
Yamazaki S, Bonito A, Spisek R, Dhodapkar M, Inaba K, Steinman R. Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood. 2007;110:4293-302 pubmed
  • flow cytometry; mouse
Jiang L, Yang P, He H, Li B, Lin X, Hou S, et al. Increased expression of Foxp3 in splenic CD8+ T cells from mice with anterior chamber-associated immune deviation. Mol Vis. 2007;13:968-74 pubmed
  • flow cytometry; mouse
Walsh C, Smith P, Fallon P. Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. Parasite Immunol. 2007;29:293-308 pubmed
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Stephens G, Andersson J, Shevach E. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol. 2007;178:6901-11 pubmed
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Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007;110:1225-32 pubmed
  • flow cytometry; mouse; fig 4B
Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
  • flow cytometry; mouse
  • western blot; mouse; fig 1B
MacKenzie D, Schartner J, Lin J, Timmel A, Jennens Clough M, Fathman C, et al. GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem. 2007;282:9696-702 pubmed
  • flow cytometry; mouse; fig 6C
Erhardt A, Biburger M, Papadopoulos T, Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology. 2007;45:475-85 pubmed
  • flow cytometry; mouse
Wang Z, Davies J. CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo. Int Immunopharmacol. 2007;7:249-65 pubmed
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Lohr J, Knoechel B, Wang J, Villarino A, Abbas A. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med. 2006;203:2785-91 pubmed
  • immunohistochemistry - paraffin section; mouse; fig 6
Gebe J, Unrath K, Falk B, Ito K, Wen L, Daniels T, et al. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol. 2006;121:294-304 pubmed
  • flow cytometry; mouse
Cassan C, Piaggio E, Zappulla J, Mars L, Couturier N, Bucciarelli F, et al. Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells. J Immunol. 2006;177:1552-60 pubmed
  • flow cytometry; mouse; fig 5
Hansen W, Loser K, Westendorf A, Bruder D, Pfoertner S, Siewert C, et al. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. J Immunol. 2006;177:209-15 pubmed
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  • flow cytometry; mouse; fig 6
Leithäuser F, Meinhardt Krajina T, Fink K, Wotschke B, Moller P, Reimann J. Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol. 2006;168:1898-909 pubmed
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Sfondrini L, Rossini A, Besusso D, Merlo A, Tagliabue E, Menard S, et al. Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer. J Immunol. 2006;176:6624-30 pubmed
  • flow cytometry; mouse
Robertson S, Messer R, Carmody A, Hasenkrug K. In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells. J Immunol. 2006;176:3342-9 pubmed
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product information
Product Type :
Antibody
Product Name :
FOXP3 Monoclonal Antibody (FJK-16s), eBioscience
Catalog # :
14-5773-82
Quantity :
100 µg
Price :
US 374
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Bovine, Canine, Feline, Mouse, Porcine, Rat
Applications :
Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Species :
Bovine, Canine, Feline, Mouse, Porcine, Rat
Clone :
FJK-16s
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Aliases :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA