CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience™ | Invitrogen 14-5759-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience™

catalog :

14-5759-82

quantity :

100 µg

price :

US 141

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBioQA79 (QA79)

reactivity :

human

application :

immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Kawasaki N, Rillahan C, Cheng T, Van Rhijn I, Macauley M, Moody D, et al. Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. J Immunol. 2014;193:1560-6 pubmed publisher
	Rillahan C, Schwartz E, Rademacher C, McBride R, Rangarajan J, Fokin V, et al. On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7. ACS Chem Biol. 2013;8:1417-22 pubmed publisher
	Farag M, Weigand K, Encke J, Momburg F. Activation of natural killer cells by hepatitis C virus particles in vitro. Clin Exp Immunol. 2011;165:352-62 pubmed publisher
	Falco M, Biassoni R, Bottino C, Vitale M, Sivori S, Augugliaro R, et al. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. J Exp Med. 1999;190:793-802 pubmed

product information

Product Type :

Antibody

Product Name :

CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience™

Catalog # :

14-5759-82

Quantity :

100 µg

Price :

US 141

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunoprecipitation: Assay-Dependent

Species :

Human

Clone :

eBioQA79 (QA79)

Isotype :

IgG1

Storage :

4° C

Description :

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunoprecipitation: Assay-Dependent

Aliases :

Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; SIGLEC-7; SIGLECP2

more info or order :

Invitrogen product webpage