MERTK Monoclonal Antibody (DS5MMER), eBioscience™ | Invitrogen 14-5751-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MERTK Monoclonal Antibody (DS5MMER), eBioscience™

catalog :

14-5751-82

quantity :

100 µg

price :

US 329

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

DS5MMER

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 26

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s3d	Bhattacharjee O, Ayyangar U, Kurbet A, Lakshmanan V, Palakodeti D, Ginhoux F, et al. Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Front Immunol. 2021;12:718005 pubmed publisher
immunohistochemistry; human; 1:200; loading ...; fig 1c	Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
flow cytometry; mouse; loading ...; fig 4c	Manils J, Webb L, Howes A, Janzen J, Boeing S, Bowcock A, et al. CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation. elife. 2020;9: pubmed publisher
flow cytometry; mouse; loading ...	Wang S, Li R, Ng T, Luthria G, Oudin M, Prytyskach M, et al. Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6:eaaz8521 pubmed publisher
flow cytometry; mouse; loading ...	Te H, Perlman D, Shenoy C, Steinberger D, Cogswell R, Roukoz H, et al. Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts. BMC Pulm Med. 2020;20:155 pubmed publisher
flow cytometry; mouse; loading ...	Lee K, Zhang Z, Achuthan A, Fleetwood A, Smith J, Hamilton J, et al. IL-23 in arthritic and inflammatory pain development in mice. Arthritis Res Ther. 2020;22:123 pubmed publisher
flow cytometry; mouse; loading ...	Woo Y, Lim J, Oh J, Lee J, Kim J. Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice. Antioxidants (Basel). 2020;9: pubmed publisher
flow cytometry; mouse; loading ...; fig 1b	Huang L, Nazarova E, Tan S, Liu Y, Russell D. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018;215:1135-1152 pubmed publisher
flow cytometry; mouse; loading ...; fig 5a	Long M, Eddy W, Gong K, Lovelace Macon L, McMahan R, Charron J, et al. MEK1/2 Inhibition Promotes Macrophage Reparative Properties. J Immunol. 2017;198:862-872 pubmed publisher
	Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
	Dou G, Tian R, Liu X, Yuan P, Ye Q, Liu J, et al. Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation. Sci Adv. 2020;6:eaba2987 pubmed publisher
	Wang F, Chen R, Jiang Q, Wu H, Gong M, Liu W, et al. Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells. Front Microbiol. 2020;11:1292 pubmed publisher
	Holtzhausen A, Harris W, Ubil E, Hunter D, Zhao J, Zhang Y, et al. TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma. Cancer Immunol Res. 2019;7:1672-1686 pubmed publisher
	Vaibhav K, Braun M, Khan M, Fatima S, Saad N, Shankar A, et al. Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation. J Exp Med. 2018;215:2636-2654 pubmed publisher
	Waterborg C, Beermann S, Broeren M, Bennink M, Koenders M, van Lent P, et al. Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models. Front Immunol. 2018;9:742 pubmed publisher
	Barnette D, Cahill T, Gunadasa Rohling M, Carr C, Freeman M, Riley P. iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction. JCI Insight. 2018;3: pubmed publisher
	Naik S, Larsen S, Gomez N, Alaverdyan K, Sendoel A, Yuan S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550:475-480 pubmed publisher
	Shenoy A, Brissac T, Gilley R, Kumar N, Wang Y, Gonzalez Juarbe N, et al. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog. 2017;13:e1006582 pubmed publisher
	Savage A, Liang H, Locksley R. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017;199:1912-1922 pubmed publisher
	Tufail Y, Cook D, Fourgeaud L, Powers C, Merten K, Clark C, et al. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron. 2017;93:574-586.e8 pubmed publisher
	Meliopoulos V, Van De Velde L, Van De Velde N, Karlsson E, Neale G, Vogel P, et al. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016;12:e1005804 pubmed publisher
	Fourgeaud L, Traves P, Tufail Y, Leal Bailey H, Lew E, Burrola P, et al. TAM receptors regulate multiple features of microglial physiology. Nature. 2016;532:240-244 pubmed publisher
	Dransfield I, ZagÃ³rska A, Lew E, Michail K, Lemke G. Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells. Cell Death Dis. 2015;6:e1646 pubmed publisher
	Rothlin C, Carrera Silva E, Bosurgi L, Ghosh S. TAM receptor signaling in immune homeostasis. Annu Rev Immunol. 2015;33:355-91 pubmed publisher
	ZagÃ³rska A, TravÃ©s P, Lew E, Dransfield I, Lemke G. Diversification of TAM receptor tyrosine kinase function. Nat Immunol. 2014;15:920-8 pubmed publisher
	Lemke G, Burstyn Cohen T. TAM receptors and the clearance of apoptotic cells. Ann N Y Acad Sci. 2010;1209:23-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MERTK Monoclonal Antibody (DS5MMER), eBioscience™

Catalog # :

14-5751-82

Quantity :

100 µg

Price :

US 329

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Frozen): 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Species :

Mouse

Clone :

DS5MMER

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Format :

Liquid

Applications w/Dilutions :

Aliases :

c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; Mer; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer

more info or order :

Invitrogen product webpage