product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR gamma/delta Monoclonal Antibody (eBioGL3 (GL-3, GL3)), eBioscience
catalog :
14-5711-82
quantity :
100 µg
price :
US 106
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
eBioGL3 (GL-3, GL3)
reactivity :
mouse
application :
immunoprecipitation, flow cytometry, mass cytometry
more info or order :
citations: 76
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 7a
Huang C, Schuring J, Skinner J, Mok L, Chong M. MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine. PLoS ONE. 2022;17:e0270820 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
Liu Y, Du J, Liu X, Wang L, Han Y, Huang C, et al. MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness. Signal Transduct Target Ther. 2021;6:321 pubmed publisher
  • mass cytometry; mouse; loading ...
Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton K, Tian L, et al. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021;125:176-189 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Qian L, Bajana S, Georgescu C, Peng V, Wang H, Adrianto I, et al. Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019;216:884-899 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a
Sadana P, Geyer R, Pezoldt J, Helmsing S, Huehn J, Hust M, et al. The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. J Biol Chem. 2018;293:8672-8690 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Dejea C, Fathi P, Craig J, Boleij A, Taddese R, Geis A, et al. Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. Science. 2018;359:592-597 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017;312:L122-L130 pubmed publisher
  • flow cytometry; mouse; fig s1a
Semenkovich N, Planer J, Ahern P, Griffin N, Lin C, Gordon J. Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 2016;113:14805-14810 pubmed publisher
  • flow cytometry; mouse; fig 2
Vigeland C, Collins S, Chan Li Y, Hughes A, Oh M, Powell J, et al. Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells. PLoS ONE. 2016;11:e0163288 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Lebrero Fernández C, Bas Forsberg A. The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine. Sci Rep. 2016;6:31524 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg M. lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets. J Immunol. 2016;197:2261-8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Chen S, Miyazaki M, Chandra V, Fisch K, Chang A, Murre C. Id3 Orchestrates Germinal Center B Cell Development. Mol Cell Biol. 2016;36:2543-52 pubmed publisher
  • flow cytometry; mouse; fig 1
Kim J, Phan T, Nguyen V, Dinh Vu H, Zheng J, Yun M, et al. Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β. Theranostics. 2015;5:1328-42 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed publisher
  • flow cytometry; mouse
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  • flow cytometry; mouse; fig 2
Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, et al. A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J Immunol. 2015;194:243-51 pubmed publisher
  • flow cytometry; mouse
Peters A, Burkett P, Sobel R, Buckley C, Watson S, Bettelli E, et al. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2015;125:129-40 pubmed publisher
  • flow cytometry; mouse
Mathew R, Seiler M, Scanlon S, Mao A, Constantinides M, Bertozzi Villa C, et al. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012;491:618-21 pubmed publisher
  • flow cytometry; mouse
Wu S, Rhee K, Albesiano E, RABIZADEH S, Wu X, Yen H, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009;15:1016-22 pubmed publisher
Filtjens J, Roger A, Quatrini L, Wieduwild E, Gouilly J, Hoeffel G, et al. Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection. Nat Commun. 2021;12:2936 pubmed publisher
Yu S, Wu X, Shi Z, Huynh M, Jena P, Sheng L, et al. Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer. J Dermatol Sci. 2020;97:194-200 pubmed publisher
Tong W, Maira M, Roychoudhury R, Galan A, Brahimi F, Gilbert M, et al. Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy. Cell Chem Biol. 2019;: pubmed publisher
Sigurdardottir S, Zapadka T, Lindstrom S, Liu H, Taylor B, Lee C, et al. Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability. Cell Immunol. 2019;:103921 pubmed publisher
Liu M, Hu Y, Yuan Y, Tian Z, Zhang C. γδT Cells Suppress Liver Fibrosis via Strong Cytolysis and Enhanced NK Cell-Mediated Cytotoxicity Against Hepatic Stellate Cells. Front Immunol. 2019;10:477 pubmed publisher
Math xe4 L, Shim H, Steer C, Yin Y, Martínez González I, Takei F. Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production. PLoS ONE. 2019;14:e0214286 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Kong M, Hashimoto Tane A, Kawashima Y, Sakuma M, Yokosuka T, Kometani K, et al. Inhibition of T cell activation and function by the adaptor protein CIN85. Sci Signal. 2019;12: pubmed publisher
Jin C, Lagoudas G, Zhao C, Bullman S, Bhutkar A, Hu B, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019;176:998-1013.e16 pubmed publisher
Seehus C, Kadavallore A, Torre B, Yeckes A, Wang Y, Tang J, et al. Alternative activation generates IL-10 producing type 2 innate lymphoid cells. Nat Commun. 2017;8:1900 pubmed publisher
Hong M, Gu B, Madison M, Landers C, Tung H, Kim M, et al. Protective role of γδ T cells in cigarette smoke and influenza infection. Mucosal Immunol. 2018;11:894-908 pubmed publisher
Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A, et al. High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells. Sci Rep. 2017;7:14076 pubmed publisher
Niki M, Nakajima K, Ishikawa D, Nishida J, Ishifune C, Tsukumo S, et al. MicroRNA-449a deficiency promotes colon carcinogenesis. Sci Rep. 2017;7:10696 pubmed publisher
Lacher S, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, et al. HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis. 2017;8:e2824 pubmed publisher
Kulig P, Musiol S, Freiberger S, Schreiner B, Gyülveszi G, Russo G, et al. IL-12 protects from psoriasiform skin inflammation. Nat Commun. 2016;7:13466 pubmed publisher
Fontana M, Baccarella A, Craft J, Boyle M, McIntyre T, Wood M, et al. A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection. PLoS ONE. 2016;11:e0162132 pubmed publisher
Klebow S, Hahn M, Nikoalev A, Wunderlich F, Hövelmeyer N, Karbach S, et al. IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis. PLoS ONE. 2016;11:e0151913 pubmed publisher
Polansky J, Bahri R, Divivier M, Duitman E, Vock C, Goyeneche Patino D, et al. High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Sci Rep. 2016;6:19699 pubmed publisher
Corpuz T, Stolp J, Kim H, Pinget G, Gray D, Cho J, et al. Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines. J Immunol. 2016;196:645-54 pubmed publisher
Derkow K, Krüger C, Dembny P, Lehnardt S. Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation. PLoS ONE. 2015;10:e0135898 pubmed publisher
Brown E, Wlodarska M, Willing B, Vonaesch P, Han J, Reynolds L, et al. Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nat Commun. 2015;6:7806 pubmed publisher
Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
Akitsu A, Ishigame H, Kakuta S, Chung S, Ikeda S, Shimizu K, et al. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells. Nat Commun. 2015;6:7464 pubmed publisher
Coll R, Robertson A, Chae J, Higgins S, Muñoz Planillo R, Inserra M, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21:248-55 pubmed publisher
Grinberg Bleyer Y, Dainichi T, Oh H, Heise N, Klein U, Schmid R, et al. Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin. J Immunol. 2015;194:2472-6 pubmed publisher
Rei M, Gonçalves Sousa N, Lança T, Thompson R, Mensurado S, Balkwill F, et al. Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A. 2014;111:E3562-70 pubmed publisher
Cao Q, Wang Y, Wang X, Lu J, Lee V, Ye Q, et al. Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy. J Am Soc Nephrol. 2015;26:349-63 pubmed publisher
Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, et al. Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect Immun. 2014;82:1606-15 pubmed publisher
Baccarella A, Fontana M, Chen E, Kim C. Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun. 2013;81:4431-42 pubmed publisher
Wang B, Zhuang X, Deng Z, Jiang H, Mu J, Wang Q, et al. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther. 2014;22:522-534 pubmed publisher
Grishkan I, Ntranos A, Calabresi P, Gocke A. Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells. Cell Immunol. 2013;284:68-74 pubmed publisher
Guo Y, Sun X, Shibata K, Yamada H, Muta H, Podack E, et al. CD30 is required for activation of a unique subset of interleukin-17A-producing ?? T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection. Infect Immun. 2013;81:3923-34 pubmed publisher
Kole A, He J, Rivollier A, Silveira D, Kitamura K, Maloy K, et al. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis. J Immunol. 2013;191:2771-9 pubmed publisher
Gonzalo Gil E, Criado G, Santiago B, Dotor J, Pablos J, Galindo M. Transforming growth factor (TGF)-? signalling is increased in rheumatoid synovium but TGF-? blockade does not modify experimental arthritis. Clin Exp Immunol. 2013;174:245-55 pubmed publisher
Cheng H, Wu R, Gebre A, Hanna R, Smith D, Parks J, et al. Increased cholesterol content in gammadelta (??) T lymphocytes differentially regulates their activation. PLoS ONE. 2013;8:e63746 pubmed publisher
Mielke L, Jones S, Raverdeau M, Higgs R, Stefanska A, Groom J, et al. Retinoic acid expression associates with enhanced IL-22 production by ?? T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210:1117-24 pubmed publisher
Jojic V, Zuk O, Sun X, Best A, Knell J, Goldrath A, et al. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013;14:633-43 pubmed publisher
Yang Q, Monticelli L, Saenz S, Chi A, Sonnenberg G, Tang J, et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013;38:694-704 pubmed publisher
Oda H, Tamehiro N, Patrick M, Hayakawa K, Suzuki H. Differential requirement for RhoH in development of TCR?? CD8?? IELs and other types of T cells. Immunol Lett. 2013;151:1-9 pubmed publisher
Jiang J, Champion C, Wei B, Liu G, Kelly K. CD8?CXCR5? T cells regulate pathology in the genital tract. Infect Dis Obstet Gynecol. 2013;2013:813238 pubmed publisher
Bahri R, Bollinger A, Bollinger T, Orinska Z, Bulfone Paus S. Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-?-mediated suppressor activities. PLoS ONE. 2012;7:e45234 pubmed publisher
Ribot J, deBarros A, Mancio Silva L, Pamplona A, Silva Santos B. B7-CD28 costimulatory signals control the survival and proliferation of murine and human ?? T cells via IL-2 production. J Immunol. 2012;189:1202-8 pubmed publisher
Valdez P, Vithayathil P, Janelsins B, Shaffer A, Williamson P, Datta S. Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells. Immunity. 2012;36:668-79 pubmed publisher
Roberts N, White A, Jenkinson W, Turchinovich G, Nakamura K, Withers D, et al. Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity. 2012;36:427-37 pubmed publisher
Zlotoff D, Zhang S, De Obaldia M, Hess P, Todd S, Logan T, et al. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011;118:1962-70 pubmed publisher
Tabbekh M, Franciszkiewicz K, Haouas H, Lecluse Y, Benihoud K, Raman C, et al. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 2011;187:102-9 pubmed publisher
Do J, Visperas A, Dong C, Baldwin W, Min B. Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ ?? T cells. J Immunol. 2011;186:4546-50 pubmed publisher
Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog. 2011;7:e1001274 pubmed publisher
Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, et al. Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis. J Immunol. 2011;186:3462-71 pubmed publisher
Liu H, Chi A, Arnett K, Chiang M, Xu L, Shestova O, et al. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010;24:2395-407 pubmed publisher
Gossens K, Naus S, Hollander G, Ziltener H. Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity. PLoS ONE. 2010;5:e12766 pubmed publisher
Redford P, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, et al. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur J Immunol. 2010;40:2200-10 pubmed publisher
Henry T, Kirimanjeswara G, Ruby T, Jones J, Peng K, Perret M, et al. Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J Immunol. 2010;184:3755-67 pubmed publisher
Shang L, Thirunarayanan N, Viejo Borbolla A, Martin A, Bogunovic M, Marchesi F, et al. Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine. Gastroenterology. 2009;137:1006-18, 1018.e1-3 pubmed publisher
Allison J, Raulet D. The immunobiology of gamma delta+ T cells. Semin Immunol. 1990;2:59-65 pubmed
Maloy K, Mowat A, Zamoyska R, Crispe I. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology. 1991;72:555-62 pubmed
Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol. 1991;147:1746-51 pubmed
product information
Product Type :
Antibody
Product Name :
TCR gamma/delta Monoclonal Antibody (eBioGL3 (GL-3, GL3)), eBioscience
Catalog # :
14-5711-82
Quantity :
100 µg
Price :
US 106
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Immunoprecipitation: Assay-Dependent
Species :
Mouse
Clone :
eBioGL3 (GL-3, GL3)
Isotype :
IgG
Storage :
4° C
Description :
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Immunoprecipitation: Assay-Dependent
Aliases :
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA