JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience | Invitrogen 14-5666-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience

catalog :

14-5666-82

quantity :

100 ug

price :

US 259.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

eBio4E10 (4E10)

reactivity :

mouse

application :

immunoprecipitation, flow cytometry

citations: 3

Reference
Witherden D, Verdino P, Rieder S, Garijo O, Mills R, Teyton L, et al. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science. 2010;329:1205-10 pubmed publisher
Zen K, Liu Y, McCall I, Wu T, Lee W, Babbin B, et al. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell. 2005;16:2694-703 pubmed
Moog Lutz C, Cavé Riant F, Guibal F, Breau M, Di Gioia Y, Couraud P, et al. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 2003;102:3371-8 pubmed

product information

Product Type :

Antibody

Product Name :

JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience

Catalog # :

14-5666-82

Quantity :

100 ug

Price :

US 259.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test, Immunoprecipitation: Assay-Dependent

Species :

Mouse

Clone :

eBio4E10 (4E10)

Isotype :

IgG

Storage :

4 C

Description :

AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test, Immunoprecipitation: Assay-Dependent

Aliases :

adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; Amica1; Crea7; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein Crea7; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Gm638; Jaml; junction adhesion molecule like; junctional adhesion molecule-like; mCrea7; UNQ722/PRO1387