JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience™ | Invitrogen 14-5666-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience™

catalog :

14-5666-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

eBio4E10 (4E10)

reactivity :

mouse

application :

immunoprecipitation, flow cytometry

citations: 1

Reference
Witherden D, Verdino P, Rieder S, Garijo O, Mills R, Teyton L, et al. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science. 2010;329:1205-10 pubmed publisher

product information

Product Type :

Antibody

Product Name :

JAML Monoclonal Antibody (eBio4E10 (4E10)), eBioscience™

Catalog # :

14-5666-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent

Species :

Mouse

Clone :

eBio4E10 (4E10)

Isotype :

IgG

Storage :

4° C

Description :

AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent

Aliases :

adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; AMICA1; Crea7; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein Crea7; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Gm638; Jaml; junction adhesion molecule like; junctional adhesion molecule-like; mCrea7; UNQ722/PRO1387