MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience | Invitrogen 14-5503-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience

catalog :

14-5503-82

quantity :

100 ug

price :

US 313.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RF6.1

reactivity :

mouse

application :

ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:200	Li P, Cui Y, Song G, Wang Z, Zhang Q. Phenotypic characteristics of nasal mast cells in a mouse model of allergic rhinitis. ORL J Otorhinolaryngol Relat Spec. 2014;76:303-13 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:20	McNeil B, Pundir P, Meeker S, Han L, Undem B, Kulka M, et al. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519:237-41 pubmed publisher
	Otani Y, Yoshikawa S, Nagao K, Tanaka T, Toyooka S, Fujimura A. Connective tissue mast cells store and release noradrenaline. J Physiol Sci. 2023;73:24 pubmed publisher
	Caughey G. Mast cell tryptases and chymases in inflammation and host defense. Immunol Rev. 2007;217:141-54 pubmed
	Knight P, Wright S, Lawrence C, Paterson Y, Miller H. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J Exp Med. 2000;192:1849-56 pubmed
	Miller H, Wright S, Knight P, Thornton E. A novel function for transforming growth factor-beta1: upregulation of the expression and the IgE-independent extracellular release of a mucosal mast cell granule-specific beta-chymase, mouse mast cell protease-1. Blood. 1999;93:3473-86 pubmed
	Wastling J, Scudamore C, Thornton E, Newlands G, Miller H. Constitutive expression of mouse mast cell protease-1 in normal BALB/c mice and its up-regulation during intestinal nematode infection. Immunology. 1997;90:308-13 pubmed

product information

Product Type :

Antibody

Product Name :

MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience

Catalog # :

14-5503-82

Quantity :

100 ug

Price :

US 313.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Species :

Mouse

Clone :

RF6.1

Isotype :

IgG1

Storage :

4 C

Description :

MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Aliases :

AV080368; mast cell protease 1; Mcp-1; Mcpt1; mMCP-1

more info or order :

Invitrogen product webpage