MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience | Invitrogen 14-5503-37 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience

catalog :

14-5503-37

quantity :

2 mg

price :

US 1482.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RF6.1

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry

citations: 1

Reference
McNeil B, Pundir P, Meeker S, Han L, Undem B, Kulka M, et al. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519:237-41 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MCPT-1 (mMCP-1) Monoclonal Antibody (RF6.1), eBioscience

Catalog # :

14-5503-37

Quantity :

2 mg

Price :

US 1482.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Species :

Mouse

Clone :

RF6.1

Isotype :

IgG1

Storage :

4 C

Description :

MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry: Assay-Dependent

Aliases :

AV080368; mast cell protease 1; Mcp-1; Mcpt1; mMCP-1