TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), eBioscience | Invitrogen 14-5499-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), eBioscience

catalog :

14-5499-82

quantity :

100 ug

price :

US 287.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBio1A6 (1A6)

reactivity :

human

application :

western blot, flow cytometry

citations: 5

Reference
Wu S, Li L, Kopp N, Montero J, Chapuy B, Yoda A, et al. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2015;28:29-41 pubmed publisher
Ott C, Kopp N, Bird L, Paranal R, Qi J, Bowman T, et al. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012;120:2843-52 pubmed publisher
Lambert Q, Pradhan A, Roll J, Reuther G. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. Biochem J. 2011;438:155-64 pubmed publisher
Soumelis V, Reche P, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;3:673-80 pubmed
Reche P, Soumelis V, Gorman D, Clifford T, Liu Mr -, Travis M, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol. 2001;167:336-43 pubmed

product information

Product Type :

Antibody

Product Name :

TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), eBioscience

Catalog # :

14-5499-82

Quantity :

100 ug

Price :

US 287.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 ug/test, Western Blot: Assay-Dependent

Species :

Human

Clone :

eBio1A6 (1A6)

Isotype :

IgG2a, lambda

Storage :

4 C

Description :

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test, Western Blot: Assay-Dependent

Aliases :

CRL2; Crlf2; CRLF2Y; Crlm2; CRLM-2; cytokine receptor CRL2 precusor; Cytokine receptor-like 2; Cytokine receptor-like factor 2; cytokine receptor-like molecule 2; delta 1; ILXR; IL-XR; Ly114; lymphocyte antigen 114; P2RY8/CRLF2 fusion; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; thymic stromal-derived lymphopoietin, receptor; Tpte2; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; TSLP receptor; Tslpr; type I cytokine receptor delta 1; WI2-87105E3.1