product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), eBioscience™
catalog :
14-5381-85
quantity :
500µg
price :
US 289
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
nonconjugated
clone name :
eBio8.1.1 (8.1.1)
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; loading ...; fig ex10d
Croft A, Campos J, Jansen K, Turner J, Marshall J, Attar M, et al. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature. 2019;570:246-251 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5e
Stock A, Hansen J, Sleeman M, McKenzie B, Wicks I. GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease. J Exp Med. 2016;213:1983-98 pubmed publisher
Obulkasim H, Shi X, Wang J, Li J, Dai B, Wu P, et al. Podoplanin is an important stromal prognostic marker in perihilar cholangiocarcinoma. Oncol Lett. 2018;15:137-146 pubmed publisher
Payne H, Ponomaryov T, Watson S, Brill A. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood. 2017;129:2013-2020 pubmed publisher
Gurung H, Carr M, Carr D. Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1. Immunol Cell Biol. 2017;95:87-98 pubmed publisher
Blanco S, Bandiera R, Popis M, Hussain S, Lombard P, Aleksic J, et al. Stem cell function and stress response are controlled by protein synthesis. Nature. 2016;534:335-40 pubmed publisher
Shinoda K, Hirahara K, Iinuma T, Ichikawa T, Suzuki A, Sugaya K, et al. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc Natl Acad Sci U S A. 2016;113:E2842-51 pubmed publisher
Nobs S, Schneider C, Heer A, Huotari J, Helenius A, Kopf M. PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection. PLoS Pathog. 2016;12:e1005508 pubmed publisher
Lua I, Li Y, Zagory J, WANG K, French S, Sévigny J, et al. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 2016;64:1137-1146 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Cloonan S, Glass K, Laucho Contreras M, Bhashyam A, Cervo M, Pabón M, et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016;22:163-74 pubmed publisher
Sapoznikov A, Falach R, Mazor O, Alcalay R, Gal Y, Seliger N, et al. Diverse profiles of ricin-cell interactions in the lung following intranasal exposure to ricin. Toxins (Basel). 2015;7:4817-31 pubmed publisher
Hitchcock J, Cook C, Bobat S, Ross E, Flores Langarica A, Lowe K, et al. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest. 2015;125:4429-46 pubmed publisher
Lynskey N, Banerji S, Johnson L, Holder K, Reglinski M, Wing P, et al. Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. PLoS Pathog. 2015;11:e1005137 pubmed publisher
Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed publisher
Lowe K, Finney B, Deppermann C, Hägerling R, Gazit S, Frampton J, et al. Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood. 2015;125:3769-77 pubmed publisher
Nakayama Y, Brinkman C, Bromberg J. Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L. Transplantation. 2015;99:1561-7 pubmed publisher
Kitamura J, Uemura M, Kurozumi M, Sonobe M, Manabe T, Hiai H, et al. Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer. PLoS ONE. 2015;10:e0117986 pubmed publisher
Acton S, Farrugia A, Astarita J, Mourão Sá D, Jenkins R, Nye E, et al. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature. 2014;514:498-502 pubmed publisher
Kizhatil K, Ryan M, Marchant J, Henrich S, John S. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol. 2014;12:e1001912 pubmed publisher
Jarjour M, Jorquera A, Mondor I, Wienert S, Narang P, Coles M, et al. Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells. J Exp Med. 2014;211:1109-22 pubmed publisher
Desai T, Brownfield D, Krasnow M. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-4 pubmed publisher
Lua I, James D, Wang J, WANG K, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014;60:311-22 pubmed publisher
Ruseva M, Takahashi M, Fujita T, Pickering M. C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014;176:84-92 pubmed publisher
Zotes T, Spada R, Mulens V, Pérez Yagüe S, Sorzano C, Okkenhaug K, et al. PI3K p110? is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LT?R mRNA levels. PLoS ONE. 2013;8:e72960 pubmed publisher
Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, et al. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem. 2013;288:2118-31 pubmed publisher
Kloxin A, Lewis K, DeForest C, Seedorf G, Tibbitt M, Balasubramaniam V, et al. Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D. Integr Biol (Camb). 2012;4:1540-9 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
Nakayama Y, Bromberg J. Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts. Am J Transplant. 2012;12:2322-34 pubmed publisher
Asahina K, Tsai S, Li P, Ishii M, Maxson R, Sucov H, et al. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009;49:998-1011 pubmed publisher
Mahtab E, Wijffels M, Van Den Akker N, Hahurij N, Lie Venema H, Wisse L, et al. Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008;237:847-57 pubmed publisher
Farr A, Berry M, Kim A, Nelson A, Welch M, Aruffo A. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med. 1992;176:1477-82 pubmed
Farr A, Nelson A, Hosier S. Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus. J Histochem Cytochem. 1992;40:651-64 pubmed
product information
Product Type :
Antibody
Product Name :
Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), eBioscience™
Catalog # :
14-5381-85
Quantity :
500µg
Price :
US 289
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Syrian Hamster
Reactivity :
Mouse, Rat
Applications :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1 µg/mL
Species :
Mouse, Rat
Clone :
eBio8.1.1 (8.1.1)
Isotype :
IgG
Storage :
4° C
Description :
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1 µg/mL
Aliases :
29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; Glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1A; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; Type I cell 40 kDa protein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA