Amphiregulin Monoclonal Antibody (AREG559), eBioscience | Invitrogen 14-5370-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Amphiregulin Monoclonal Antibody (AREG559), eBioscience

catalog :

14-5370-82

quantity :

100 ug

price :

US 285.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AREG559

reactivity :

human

application :

western blot, flow cytometry

citations: 1

Reference
Wang Y, Lifshitz L, Silverstein N, Mintzer E, Luk K, StLouis P, et al. Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis. EMBO J. 2023;42:e114153 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Amphiregulin Monoclonal Antibody (AREG559), eBioscience

Catalog # :

14-5370-82

Quantity :

100 ug

Price :

US 285.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent, Western Blot: 1-10 ug/mL

Species :

Human

Clone :

AREG559

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Western Blot: 1-10 ug/mL

Aliases :

amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF