cGAS Monoclonal Antibody (HGAYN), eBioscience | Invitrogen 14-5158-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

cGAS Monoclonal Antibody (HGAYN), eBioscience

catalog :

14-5158-82

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HGAYN

reactivity :

human

application :

western blot

citations: 1

Reference
Omer A, Barrera M, Moran J, Lian X, Di Marco S, Beausejour C, et al. G3BP1 controls the senescence-associated secretome and its impact on cancer progression. Nat Commun. 2020;11:4979 pubmed publisher

product information

Product Type :

Antibody

Product Name :

cGAS Monoclonal Antibody (HGAYN), eBioscience

Catalog # :

14-5158-82

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Western Blot: 1-2 ug/mL

Species :

Human

Clone :

HGAYN

Isotype :

IgG2b, kappa

Storage :

4 C, do not freeze

Description :

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.

Immunogen :

E. coli-derived recombinant human cGAS protein

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1-2 ug/mL

Aliases :

C6orf150; h-cGAS; MB21D1