product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
EOMES Monoclonal Antibody (Dan11mag), eBioscience™
catalog :
14-4875-37
quantity :
2 mg
price :
1200.00 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
Dan11mag
reactivity :
mouse
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 41
Reference
Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, et al. Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome. elife. 2019;8: pubmed publisher
S nchez Guardado L, Lois C. Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb. elife. 2019;8: pubmed publisher
Rolot M, Dougall A, Chetty A, Javaux J, Chen T, Xiao X, et al. Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nat Commun. 2018;9:4516 pubmed publisher
Singh M, Ni M, Sullivan J, Hamerman J, Campbell D. B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation. J Exp Med. 2018;215:2429-2443 pubmed publisher
Wang B, Joo J, Mount R, Teubner B, Krenzer A, Ward A, et al. The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018;128:3319-3332 pubmed publisher
Silva C, Peyre E, Adhikari M, Tielens S, Tanco S, Van Damme P, et al. Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell. 2018;172:1063-1078.e19 pubmed publisher
Wang H, Li J, Han Q, Yang F, Xiao Y, Xiao M, et al. IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis. Int J Med Sci. 2017;14:977-983 pubmed publisher
Probst S, Daza R, Bader N, Hummel J, Weiß M, Tanriver Y, et al. A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing. Genesis. 2017;55: pubmed publisher
Vasanthakumar A, Xu D, Lun A, Kueh A, van Gisbergen K, Iannarella N, et al. A non-canonical function of Ezh2 preserves immune homeostasis. EMBO Rep. 2017;18:619-631 pubmed publisher
Chamoto K, Chowdhury P, Kumar A, Sonomura K, Matsuda F, Fagarasan S, et al. Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E761-E770 pubmed publisher
Haushalter C, Schuhbaur B, Dolle P, Rhinn M. Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development. Biol Open. 2017;6:148-160 pubmed publisher
Hoegl S, Ehrentraut H, Brodsky K, Victorino F, Golden Mason L, Eltzschig H, et al. NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol. 2017;101:471-480 pubmed publisher
Martínez Gómez J, Periasamy P, Dutertre C, Irving A, Ng J, Crameri G, et al. Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto. Sci Rep. 2016;6:37796 pubmed publisher
Hu Y, Kim J, He K, Wan Q, Kim J, Flach M, et al. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016;213:2759-2772 pubmed
Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed publisher
Fame R, MacDonald J, Dunwoodie S, Takahashi E, Macklis J. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016;36:6403-19 pubmed publisher
Wang L, Hou S, Han Y. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci. 2016;19:888-96 pubmed publisher
Takeo Y, Kurabayashi N, Nguyen M, Sanada K. The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway. Sci Rep. 2016;6:25180 pubmed publisher
Hamblet C, Makowski S, Tritapoe J, Pomerantz J. NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. J Immunol. 2016;196:2614-26 pubmed publisher
Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 2016;530:57-62 pubmed publisher
Mackay L, Wynne Jones E, Freestone D, Pellicci D, Mielke L, Newman D, et al. T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate. Immunity. 2015;43:1101-11 pubmed publisher
Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, et al. NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine. PLoS ONE. 2015;10:e0143224 pubmed publisher
Gupta P, Godec J, Wolski D, Adland E, Yates K, Pauken K, et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015;11:e1005177 pubmed publisher
Pearce V, Bouabe H, MacQueen A, Carbonaro V, Okkenhaug K. PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. J Immunol. 2015;195:3206-17 pubmed publisher
Kim M, Taparowsky E, Kim C. Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut. Immunity. 2015;43:107-19 pubmed publisher
Pollizzi K, Patel C, Sun I, Oh M, Waickman A, Wen J, et al. mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. J Clin Invest. 2015;125:2090-108 pubmed publisher
Pascutti M, Geerman S, Slot E, van Gisbergen K, Boon L, Arens R, et al. Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection. PLoS Pathog. 2015;11:e1004675 pubmed publisher
Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, et al. The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015;29:409-25 pubmed publisher
Dobenecker M, Kim J, Marcello J, Fang T, Prinjha R, Bosselut R, et al. Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation. J Exp Med. 2015;212:297-306 pubmed publisher
Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Exp Med. 2015;212:253-65 pubmed publisher
Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015;194:125-133 pubmed publisher
Nair S, Fang M, Sigal L. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment. Aging Cell. 2015;14:180-90 pubmed publisher
Iwashita M, Kataoka N, Toida K, Kosodo Y. Systematic profiling of spatiotemporal tissue and cellular stiffness in the developing brain. Development. 2014;141:3793-8 pubmed publisher
Seillet C, Huntington N, Gangatirkar P, Axelsson E, Minnich M, Brady H, et al. Differential requirement for Nfil3 during NK cell development. J Immunol. 2014;192:2667-76 pubmed publisher
Zumwalde N, Domae E, Mescher M, Shimizu Y. ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation. J Immunol. 2013;191:3681-93 pubmed publisher
Knudson K, Goplen N, Cunningham C, Daniels M, Teixeiro E. Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands. Cell Rep. 2013;4:554-65 pubmed publisher
Sandy A, Chung J, Toubai T, Shan G, Tran I, Friedman A, et al. T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells. J Immunol. 2013;190:5818-28 pubmed publisher
Mizuguchi R, Naritsuka H, Mori K, Mao C, Klein W, Yoshihara Y. Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. J Neurosci. 2012;32:8831-44 pubmed publisher
Li Q, Rao R, Vazzana J, Goedegebuure P, Odunsi K, Gillanders W, et al. Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity. J Immunol. 2012;188:3080-7 pubmed publisher
Qui H, Hagymasi A, Bandyopadhyay S, St Rose M, Ramanarasimhaiah R, Menoret A, et al. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol. 2011;187:3555-64 pubmed publisher
Marshall H, Prince A, Berg L, Welsh R. IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol. 2010;185:1419-28 pubmed publisher
product information
Product Type :
Antibody
Product Name :
EOMES Monoclonal Antibody (Dan11mag), eBioscience™
Catalog # :
14-4875-37
Quantity :
2 mg
Price (USD) :
1200.00 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Species :
Mouse
Clone :
Dan11mag
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
TBR2 is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation. TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Aliases :
C77258; Eomes; eomesodermin; eomesodermin homolog; eomesodermin homolog (Xenopus laevis); T-box brain protein 2; Tbr2; TBR-2; T-brain-2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA