FOXP3 Monoclonal Antibody (NRRF-30), eBioscience™ | Invitrogen 14-4771-95 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FOXP3 Monoclonal Antibody (NRRF-30), eBioscience™

catalog :

14-4771-95

quantity :

10 mg

price :

US 3000.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

NRRF-30

reactivity :

mouse

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

citations: 17

Reference
Chen Q, Xu L, Liang C, Wang C, Peng R, Liu Z. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Commun. 2016;7:13193 pubmed publisher
Patel M, Kim J, Theodros D, Tam A, Velarde E, Kochel C, et al. Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. J Immunother Cancer. 2016;4:28 pubmed publisher
Pallangyo C, Ziegler P, Greten F. IKKÎ² acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed publisher
Ahn B, Kohanbash G, Ohkuri T, Kosaka A, Chen X, Ikeura M, et al. Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas. Oncoimmunology. 2015;4:e1047581 pubmed
Sanin D, Prendergast C, Bourke C, Mountford A. Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. PLoS Pathog. 2015;11:e1004841 pubmed publisher
Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, et al. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014;2:1199-208 pubmed publisher
Devaud C, Yong C, John L, Westwood J, Duong C, House C, et al. Foxp3 expression in macrophages associated with RENCA tumors in mice. PLoS ONE. 2014;9:e108670 pubmed publisher
Maneva Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS ONE. 2014;9:e107213 pubmed publisher
Surana R, Wang S, Xu W, Jablonski S, Weiner L. IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model. Cancer Immunol Res. 2014;2:1103-12 pubmed publisher
Kosaka A, Ohkuri T, Okada H. Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. Cancer Immunol Immunother. 2014;63:847-57 pubmed publisher
EGHTESAD S, Jhunjhunwala S, Little S, Clemens P. Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle. Mol Med. 2011;17:917-24 pubmed publisher
McCarl C, Khalil S, Ma J, Oh Hora M, Yamashita M, Roether J, et al. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185:5845-58 pubmed publisher
EGHTESAD S, Zheng H, Nakai H, Epperly M, Clemens P. Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity. Gene Ther. 2010;17:1181-90 pubmed publisher
O Gorman W, Dooms H, Thorne S, Kuswanto W, Simonds E, Krutzik P, et al. The initial phase of an immune response functions to activate regulatory T cells. J Immunol. 2009;183:332-9 pubmed publisher
van Olffen R, Koning N, van Gisbergen K, Wensveen F, Hoek R, Boon L, et al. GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol. 2009;182:7490-500 pubmed publisher
Verhagen J, GabrysovÃ¡ L, Minaee S, Sabatos C, Anderson G, Sharpe A, et al. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A. 2009;106:3306-11 pubmed publisher
de Zoeten E, Lee I, Wang L, Chen C, Ge G, Wells A, et al. Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem. 2009;284:5709-16 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FOXP3 Monoclonal Antibody (NRRF-30), eBioscience™

Catalog # :

14-4771-95

Quantity :

10 mg

Price :

US 3000.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL

Species :

Mouse

Clone :

NRRF-30

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL

Aliases :

AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID