This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
beta Catenin Monoclonal Antibody (15B8), eBioscience
catalog :
14-2567-82
quantity :
100 ug
price :
US 272.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
15B8

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 17
Reference
Thomas R, Pahl M, Wang L, Grant S, Hancock W, Wells A. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function. elife. 2024;12: pubmed publisher
Seltmann K, Hettich B, Abele S, Gurri S, Mantella V, Leroux J, et al. Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration. J Extracell Vesicles. 2024;13:e12430 pubmed publisher
Hao J, Liu C, Gu Z, Yang X, Lan X, Guo X. Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells. Nat Commun. 2024;15:2820 pubmed publisher
Hamam S, Abdelzaher E, Fadel S, Nassra R, Sharafeldin H. Prognostic value of microRNA-125a expression status in molecular groups of pediatric medulloblastoma. Childs Nerv Syst. 2023;39:1869-1880 pubmed publisher
Sung B, Lin Y, Kong Q, Shah P, Glick Bieler J, Palmer S, et al. Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1. J Clin Invest. 2022;132: pubmed publisher
Sarabia Sánchez M, Alvarado Ortiz E, Toledo Guzman M, Garcia Carranca A, Ortiz Sánchez E. ALDHHIGH Population Is Regulated by the AKT/β-Catenin Pathway in a Cervical Cancer Model. Front Oncol. 2020;10:1039 pubmed publisher
Volpini X, Ambrosio L, Fozzatti L, Insfrán C, Stempin C, Cervi L, et al. Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol. 2018;9:859 pubmed publisher
Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, et al. Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Cell Transplant. 2017;26:1365-1379 pubmed publisher
Zuppinger C, Gibbons G, Dutta Passecker P, Segiser A, Most H, Suter T. Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes. Eur J Histochem. 2017;61:2763 pubmed publisher
Liang S, Marti T, Dorn P, Froment L, Hall S, Berezowska S, et al. Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer. Cell Death Dis. 2015;6:e1824 pubmed publisher
Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, Gasche C. Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells. Biochem Pharmacol. 2014;87:312-20 pubmed publisher
Liu S, Li N, Yu X, Xiao X, Cheng K, Hu J, et al. Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells. Gastroenterology. 2013;144:1031-1041.e10 pubmed publisher
Barber A, Sentman C. NKG2D receptor regulates human effector T-cell cytokine production. Blood. 2011;117:6571-81 pubmed publisher
Xu M, Sharma A, Hossain M, Wiest D, Sen J. Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. J Immunol. 2009;182:759-65 pubmed
Staal F, Sen J. The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol. 2008;38:1788-94 pubmed publisher
Xu Y, Banerjee D, Huelsken J, Birchmeier W, Sen J. Deletion of beta-catenin impairs T cell development. Nat Immunol. 2003;4:1177-82 pubmed
Hoschuetzky H, Aberle H, Kemler R. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol. 1994;127:1375-80 pubmed
product information
Product Type :
Antibody
Product Name :
beta Catenin Monoclonal Antibody (15B8), eBioscience
Catalog # :
14-2567-82
Quantity :
100 ug
Price :
US 272.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 1 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 ug/mL
Species :
Human, Mouse
Clone :
15B8
Isotype :
IgG1, kappa
Storage :
4 C
Description :
Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 1 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 ug/mL
Aliases :
armadillo; armadillo homolog; Bcatenin; b-catenin; beta 1 88kDa; beta catenin; Betacatenin; beta-catenin; beta-catenin 1; Bfc; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein) beta 1; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; catenin beta 1; catenin beta 1 L homeolog; Catenin beta1; Catenin beta-1; Catenin ß 1; Catenin ß1; Catnb; CHBCAT; CTNB1; CTNNB; ctnnb1; ctnnb1.L; ctnnb1-a; ctnnb1-b; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; id:ibd2058; Mesc; MRD19; NAP; NYD-SP19; OK/SW-cl.35; OTTHUMP00000209289; P14L; PP8304; PRO2286; RP5-1118M15.1; wu:fb73e10; wu:fi81c06; wu:fk25h01; XELAEV_18031149mg; ß catenin; ßcatenin
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA