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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD207 (Langerin) Monoclonal Antibody (eBioL31), eBioscience
catalog :
14-2075-82
quantity :
100 µg
price :
US 317.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eBioL31
reactivity :
mouse
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 31
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig s1e
Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher
  • flow cytometry; mouse
MANICONE A, Huizar I, McGuire J. Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin). Am J Pathol. 2009;175:2319-31 pubmed publisher
Nasir G, Sinnis P. Transport of antibody into the skin is only partially dependent upon the neonatal Fc-receptor. PLoS ONE. 2023;18:e0273960 pubmed publisher
Tordesillas L, Lozano Ojalvo D, Dunkin D, Mondoulet L, Agudo J, Merad M, et al. PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs. Nat Commun. 2018;9:5238 pubmed publisher
Takeda K, WEBB T, Ning F, Shiraishi Y, Regan D, Chow L, et al. Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation. J Immunol. 2018;200:1261-1269 pubmed publisher
Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, et al. Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling. J Exp Med. 2017;214:2933-2946 pubmed publisher
Chung J, Ebens C, Perkey E, Radojcic V, Koch U, Scarpellino L, et al. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest. 2017;127:1574-1588 pubmed publisher
Wu X, Briseño C, Durai V, Albring J, Haldar M, Bagadia P, et al. Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells. J Exp Med. 2016;213:2553-2565 pubmed
Guerrini M, Okamoto K, Komatsu N, Sawa S, Danks L, Penninger J, et al. Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 2015;43:1174-85 pubmed publisher
Trautwein Weidner K, Gladiator A, Kirchner F, Becattini S, Rülicke T, Sallusto F, et al. Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis. PLoS Pathog. 2015;11:e1005164 pubmed publisher
Capucha T, Mizraji G, Segev H, Blecher Gonen R, Winter D, Khalaileh A, et al. Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes. Immunity. 2015;43:369-81 pubmed publisher
Stary G, Olive A, Radovic Moreno A, Gondek D, Alvarez D, Basto P, et al. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015;348:aaa8205 pubmed publisher
Hansell C, Maclellan L, Oldham R, Doonan J, Chapple K, Anderson E, et al. The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunol Cell Biol. 2015;93:167-76 pubmed publisher
Berres M, Lim K, Peters T, Price J, Takizawa H, Salmon H, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. J Exp Med. 2014;211:669-83 pubmed publisher
Heine S, Diaz McNair J, Andar A, Drachenberg C, Van de Verg L, Walker R, et al. Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes. J Immunol. 2014;192:1630-40 pubmed publisher
Elnekave M, Furmanov K, Shaul Y, Capucha T, Eli Berchoer L, Zelentsova K, et al. Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming. J Immunol. 2014;192:1395-403 pubmed publisher
Mollah S, Dobrin J, Feder R, Tse S, Matos I, Cheong C, et al. Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. J Invest Dermatol. 2014;134:1265-1275 pubmed publisher
Maina V, Marrella V, Mantero S, Cassani B, Fontana E, Anselmo A, et al. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol. 2013;94:1221-30 pubmed publisher
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed publisher
Khandelwal P, Blanco Mezquita T, Emami P, Lee H, Reyes N, Mathew R, et al. Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. PLoS ONE. 2013;8:e64193 pubmed publisher
Matsuo K, Ishii Y, Kawai Y, Saiba Y, Quan Y, Kamiyama F, et al. Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation. J Pharm Sci. 2013;102:1936-1947 pubmed publisher
Dong H, Stanek O, Salvador F, Langer U, Morillon E, Ung C, et al. Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells. Mucosal Immunol. 2013;6:522-34 pubmed publisher
Nakamura T, Nishibu A, Yasoshima M, Tanoue C, Yoshida N, Hatta J, et al. Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse. J Dermatol Sci. 2012;66:144-53 pubmed publisher
Otsuka A, Kubo M, Honda T, Egawa G, Nakajima S, Tanizaki H, et al. Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity. PLoS ONE. 2011;6:e25538 pubmed publisher
Li H, Kaplan D, Matte Martone C, Tan H, Venkatesan S, Johnson K, et al. Langerhans cells are not required for graft-versus-host disease. Blood. 2011;117:697-707 pubmed publisher
Arthur J, Lich J, Ye Z, Allen I, Gris D, Wilson J, et al. Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol. 2010;185:4515-9 pubmed publisher
Freire T, Zhang X, Deriaud E, Ganneau C, Vichier Guerre S, Azria E, et al. Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. Blood. 2010;116:3526-36 pubmed publisher
Kratzer R, Mauvais F, Burgevin A, Barilleau E, van Endert P. Fusion proteins for versatile antigen targeting to cell surface receptors reveal differential capacity to prime immune responses. J Immunol. 2010;184:6855-64 pubmed publisher
Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med. 2010;16:713-7 pubmed publisher
Qiu C, Miyake Y, Kaise H, Kitamura H, Ohara O, Tanaka M. Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol. 2009;182:4127-36 pubmed publisher
Idoyaga J, Suda N, Suda K, Park C, Steinman R. Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 2009;106:1524-9 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD207 (Langerin) Monoclonal Antibody (eBioL31), eBioscience
Catalog # :
14-2075-82
Quantity :
100 µg
Price :
US 317.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1 µg/test
Species :
Mouse
Clone :
eBioL31
Isotype :
IgG2a
Storage :
4° C
Description :
Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1 µg/test
Aliases :
CD 207 antigen; CD207; CD207 antigen; CD207 antigen, langerin; CD207 molecule; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin; langerin; RGD1565913
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA