CD207 (Langerin) Monoclonal Antibody (eBioRMUL.2), eBioscience | Invitrogen 14-2073-37 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD207 (Langerin) Monoclonal Antibody (eBioRMUL.2), eBioscience

catalog :

14-2073-37

quantity :

2 mg

price :

US 1452

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

eBioRMUL.2

reactivity :

mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 5 ug/ml; loading ...; fig 4a	Tatsumi N, Codrington A, El Fenej J, Phondge V, Kumamoto Y. Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry. Sci Immunol. 2021;6:eabg0336 pubmed publisher
	Antunes K, Cass xe3 o G, Santos L, Borges S, Poppe J, Gon xe7 alves J, et al. Airway Administration of Bacterial Lysate OM-85 Protects Mice Against Respiratory Syncytial Virus Infection. Front Immunol. 2022;13:867022 pubmed publisher
	Nakajima K, Kataoka S, Sato K, Takaishi M, Yamamoto M, Nakajima H, et al. Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production. J Dermatol Sci. 2019;93:82-91 pubmed publisher
	Jatana S, Palmer B, Phelan S, Gelein R, Delouise L. In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation. Part Fibre Toxicol. 2017;14:12 pubmed publisher
	Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll U, Seegobin S, et al. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. FASEB J. 2017;31:526-543 pubmed publisher
	Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lönnerberg P, et al. Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. Cell Syst. 2016;3:221-237.e9 pubmed publisher
	Chen Q, Li R, Zhao X, Liang B, Ma S, Li Z, et al. Prevention of ultraviolet radiation?induced immunosuppression by sunscreen in Candida albicans?induced delayed?type hypersensitivity. Mol Med Rep. 2016;14:202-8 pubmed publisher
	Lewis J, BÃ¼rgler C, Freudzon M, Golubets K, Gibson J, Filler R, et al. Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. J Invest Dermatol. 2015;135:2824-2833 pubmed publisher
	Yoo J, MANICONE A, McGuire J, Wang Y, Parks W. Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis. J Inflamm Res. 2014;7:29-38 pubmed publisher
	Fukunaga A, Khaskhely N, Ma Y, Sreevidya C, Taguchi K, Nishigori C, et al. Langerhans cells serve as immunoregulatory cells by activating NKT cells. J Immunol. 2010;185:4633-40 pubmed publisher
	Idoyaga J, Suda N, Suda K, Park C, Steinman R. Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 2009;106:1524-9 pubmed publisher
	Molinero L, Zhou P, Wang Y, Harlin H, Kee B, Abraham C, et al. Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells. Am J Transplant. 2008;8:21-31 pubmed
	Doepping S, Funk C, Habenicht A, Spanbroek R. Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin. J Invest Dermatol. 2007;127:1692-700 pubmed

product information

Product Type :

Antibody

Product Name :

CD207 (Langerin) Monoclonal Antibody (eBioRMUL.2), eBioscience

Catalog # :

14-2073-37

Quantity :

2 mg

Price :

US 1452

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Western Blot: 2 µg/mL

Species :

Mouse

Clone :

eBioRMUL.2

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Western Blot: 2 µg/mL

Aliases :

CD 207 antigen; CD207; CD207 antigen; CD207 antigen, langerin; CD207 molecule; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin; langerin; RGD1565913

more info or order :

Invitrogen product webpage