CD196 (CCR6) Monoclonal Antibody (R6H1), eBioscience | Invitrogen 14-1969-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD196 (CCR6) Monoclonal Antibody (R6H1), eBioscience

catalog :

14-1969-80

quantity :

25 µg

price :

US 127.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

R6H1

reactivity :

human, rat

application :

western blot, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human	Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed publisher
western blot; rat	Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-? production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Ann Rheum Dis. 2014;73:1223-31 pubmed publisher
	Zou M, Zhang X, Jiang D, Zhao Y, Wu T, Gong Q, et al. Transcriptional Regulation of CD40 Expression by 4 Ribosomal Proteins via a Functional SNP on a Disease-Associated CD40 Locus. Genes (Basel). 2020;11: pubmed publisher
	Win Maung H, Chan On W, Kunkeaw N, Khaenam P. Common transcriptional programs and the role of chemokine (C-C motif) ligand 20 (CCL20) in cell migration of cholangiocarcinoma. EXCLI J. 2020;19:154-166 pubmed publisher
	Wallin E, Hill D, Linterman M, Wood K. The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells. Front Immunol. 2018;9:1184 pubmed publisher
	Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, et al. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLoS Genet. 2016;12:e1006292 pubmed publisher
	Skovdahl H, Granlund A, Ã˜stvik A, Bruland T, Bakke I, Torp S, et al. Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells. PLoS ONE. 2015;10:e0141710 pubmed publisher
	Zhang W, Nie L, Wang Y, Wang X, Zhao H, Dongol S, et al. CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues. PLoS ONE. 2013;8:e66286 pubmed publisher
	Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013;190:3142-52 pubmed publisher
	Lang J, Kelly M, Freed B, McCarter M, Kedl R, Torres R, et al. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013;190:2090-101 pubmed publisher
	Kenna T, Davidson S, Duan R, Bradbury L, McFarlane J, Smith M, et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive ?/? T cells in patients with active ankylosing spondylitis. Arthritis Rheum. 2012;64:1420-9 pubmed publisher
	Lugering A, Ross M, Sieker M, Heidemann J, Williams I, Domschke W, et al. CCR6 identifies lymphoid tissue inducer cells within cryptopatches. Clin Exp Immunol. 2010;160:440-9 pubmed publisher
	Liu H, Rohowsky Kochan C. Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol. 2008;180:7948-57 pubmed
	Singh S, Zhang H, Foley J, Hedrick M, Farber J. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008;180:214-21 pubmed
	Lim H, Lee J, Hillsamer P, Kim C. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008;180:122-9 pubmed
	Carramolino L, Kremer L, Goya I, Varona R, Buesa J, Gutierrez J, et al. Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4. J Leukoc Biol. 1999;66:837-44 pubmed

product information

Product Type :

Antibody

Product Name :

CD196 (CCR6) Monoclonal Antibody (R6H1), eBioscience

Catalog # :

14-1969-80

Quantity :

25 µg

Price :

US 127.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 5 µg/mL

Species :

Human

Clone :

R6H1

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 5 µg/mL

Aliases :

BN-1; CC chemokine receptor 6; C-C chemokine receptor type 6; C-C CKR-6; C-C motif chemokine receptor 6; CC-CKR-6; CCR6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKR6; CKRL3; CKR-L3; Cmkbr6; DCR2; DRY6; DRY-6; G protein-coupled receptor 29; GPR29; GPRCY4; GPR-CY4; G-protein coupled receptor 29; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22

more info or order :

Invitrogen product webpage