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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), eBioscience
catalog :
14-1331-80
quantity :
25 µg
price :
US 114.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
13A4
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 96
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Ma Y, Deng M, Zhao X, Liu M. Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway. Exp Neurobiol. 2020;29:150-163 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 2e
Athanasiou D, Aguilà M, Opefi C, South K, Bellingham J, Bevilacqua D, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017;26:305-319 pubmed publisher
  • immunohistochemistry; human; 1:200; fig s1
Jun S, Jung Y, Suh H, Wang W, Kim M, Oh Y, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016;7:10994 pubmed publisher
  • flow cytometry; human; fig  1
Das J, Voelkel N, Felty Q. ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases. Microvasc Res. 2015;98:126-38 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 6
Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita Fujimura Y, et al. Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease. Brain Res. 2015;1594:310-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
  • western blot; mouse; 1:100
Holmberg Olausson K, Maire C, Haidar S, Ling J, Learner E, Nistér M, et al. Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas. PLoS ONE. 2014;9:e106694 pubmed publisher
  • flow cytometry; mouse; 1:50
Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig 2
  • immunohistochemistry; mouse; 1:500; fig 1
Main H, Radenkovic J, Jin S, Lendahl U, Andersson E. Notch signaling maintains neural rosette polarity. PLoS ONE. 2013;8:e62959 pubmed publisher
  • flow cytometry; mouse
Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
  • flow cytometry; mouse; 1:50
Buono K, Vadlamuri D, Gan Q, Levison S. Leukemia inhibitory factor is essential for subventricular zone neural stem cell and progenitor homeostasis as revealed by a novel flow cytometric analysis. Dev Neurosci. 2012;34:449-62 pubmed publisher
  • flow cytometry; mouse; 1:100
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, et al. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet. 2013;45:98-103 pubmed publisher
  • flow cytometry; mouse; fig 7
  • immunohistochemistry; mouse; fig 7
Mukouyama Y, Deneen B, Lukaszewicz A, Novitch B, Wichterle H, Jessell T, et al. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006;103:1551-6 pubmed
Oh H, Heo W, Yoo G, Kim K, Hwang J, Hwang E, et al. CD133-Src-TAZ signaling stimulates ductal fibrosis following DDC diet-induced liver injury. J Cell Physiol. 2022;237:4504-4516 pubmed publisher
Seo S, Kim E, Yoon M, Lee S, Park B, Choi K. Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment. Exp Mol Med. 2022;54:1511-1523 pubmed publisher
Serra C, Liu H, Qian J, Mori M, LU J, Cardoso W. Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. iScience. 2022;25:104751 pubmed publisher
Ye X, Li M, Bian W, Wu A, Zhang T, Li J, et al. RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells in both in vitro and in vivo studies. Eur J Neurosci. 2022;56:3839-3860 pubmed publisher
Liu X, Rulina A, Choi M, Pedersen L, Lepland J, Takle S, et al. C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer. Nat Commun. 2022;13:69 pubmed publisher
Velloso F, Kumari E, Buono K, Frondelli M, Levison S. Analyzing mouse neural stem cell and progenitor cell proliferation using EdU incorporation and multicolor flow cytometry. STAR Protoc. 2022;3:101065 pubmed publisher
Ezzeldeen Y, Swidan S, ElMeshad A, Sebak A. Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma. Int J Nanomedicine. 2021;16:5693-5712 pubmed publisher
Belenguer G, Duart Abadia P, Domingo Muelas A, Morante Redolat J, Farinas I. Cell population analysis of the adult murine subependymal neurogenic lineage by flow cytometry. STAR Protoc. 2021;2:100425 pubmed publisher
Yarmishyn A, Yang Y, Lu K, Chen Y, Chien Y, Chou S, et al. Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1. Cancer Cell Int. 2020;20:597 pubmed publisher
Gagniac L, Rusidzé M, Boudou F, Cagnet S, Adlanmerini M, Jeannot P, et al. Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium. Development. 2020;147: pubmed publisher
Min J, Vega P, Engevik A, Williams J, Yang Q, Patterson L, et al. Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach. Nat Commun. 2019;10:5549 pubmed publisher
Asahina K, Balog S, Hwang E, Moon E, Wan E, Skrypek K, et al. Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras. Am J Physiol Gastrointest Liver Physiol. 2020;318:G265-G276 pubmed publisher
Zurkirchen L, Varum S, Giger S, Klug A, Häusel J, Bossart R, et al. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019;10:2192 pubmed publisher
Robson J, Remke M, Kool M, Julian E, Korshunov A, Pfister S, et al. Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells. PLoS ONE. 2019;14:e0210665 pubmed publisher
Edamakanti C, Do J, Didonna A, Martina M, Opal P. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018;128:2252-2265 pubmed publisher
Li F, Ma Z, Liu H, Zhang Q, Cai X, Qu Y, et al. Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-β/ERK/p90RSK Signalling. Stem Cells Int. 2017;2017:6193106 pubmed publisher
Albert M, Kalebic N, Florio M, Lakshmanaperumal N, Haffner C, Brandl H, et al. Epigenome profiling and editing of neocortical progenitor cells during development. EMBO J. 2017;36:2642-2658 pubmed publisher
Yu L, Chen S, Luo N, He S. The C-terminus domain of the hepatitis B virus x protein stimulates the proliferation of mouse foetal hepatic progenitor cells, although it is not required for the formation of spheroids. Int J Mol Med. 2017;40:400-410 pubmed publisher
Beattie R, Postiglione M, Burnett L, Laukoter S, Streicher C, Pauler F, et al. Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells. Neuron. 2017;94:517-533.e3 pubmed publisher
Shang Z, Xu Y, Liang W, Liang K, Hu X, Wang L, et al. Isolation of cancer progenitor cells from cancer stem cells in gastric cancer. Mol Med Rep. 2017;15:3637-3643 pubmed publisher
Weng L, Hu X, Kumar B, García M, Todorov I, Jung X, et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep. 2016;6:38632 pubmed publisher
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
Le Coz V, Zhu C, Devocelle A, Vazquez A, Boucheix C, Azzi S, et al. IGF-1 contributes to the expansion of melanoma-initiating cells through an epithelial-mesenchymal transition process. Oncotarget. 2016;7:82511-82527 pubmed publisher
Wang K, Zhou X, Wu M, Kang F, Wang Z, Zhu Y. Role of CD133+ cells in tongue squamous carcinomas: Characteristics of 'stemness' in vivo and in vitro. Oncol Lett. 2016;12:863-870 pubmed
Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Siavashi V, Nassiri S, Rahbarghazi R, Vafaei R, Sariri R. ECM-Dependence of Endothelial Progenitor Cell Features. J Cell Biochem. 2016;117:1934-46 pubmed publisher
Oudin M, Hughes S, Rohani N, Moufarrej M, Jones J, Condeelis J, et al. Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clin Exp Metastasis. 2016;33:249-61 pubmed publisher
Dosch J, Ziemke E, Shettigar A, Rehemtulla A, Sebolt Leopold J. Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer. Cancer Res. 2015;75:4582-92 pubmed publisher
Kaushal G, Rognoni E, Lichtenberger B, Driskell R, Kretzschmar K, Hoste E, et al. Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation. J Invest Dermatol. 2015;135:2926-2934 pubmed publisher
Luo Y, Coskun V, Liang A, Yu J, Cheng L, Ge W, et al. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell. 2015;161:1175-1186 pubmed publisher
Zechner D, Radecke T, Amme J, Bürtin F, Albert A, Partecke L, et al. Impact of diabetes type II and chronic inflammation on pancreatic cancer. BMC Cancer. 2015;15:51 pubmed publisher
Cuevas E, Rybak Wolf A, Rohde A, Nguyen D, Wulczyn F. Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20 pubmed publisher
Carulli A, Keeley T, Demitrack E, Chung J, Maillard I, Samuelson L. Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration. Dev Biol. 2015;402:98-108 pubmed publisher
Torres C, Olivares A, Stoore C. Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells. Oncol Rep. 2015;33:2235-44 pubmed publisher
Murray A, Vuong L, Brobst D, Fliesler S, Peachey N, Gorbatyuk M, et al. Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs. Hum Mol Genet. 2015;24:2709-23 pubmed publisher
Miller T, Wang J, Sukhdeo K, Horbinski C, Tesar P, Wechsler Reya R, et al. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS ONE. 2014;9:e114433 pubmed publisher
Liu B, Yang L, Lu X, Song X, Li X, Chen G, et al. Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol. 2015;26:1576-87 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Jin L, Feng T, Chai J, Ghazalli N, Gao D, Zerda R, et al. Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures. Rev Diabet Stud. 2014;11:35-50 pubmed publisher
Quante T, Wegwitz F, Abe J, Rossi A, Deppert W, Bohn W. Aberrant Proliferation of Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of SV40-TAg Transgenic Mice. Front Oncol. 2014;4:168 pubmed publisher
Sun W, Wilhelmina Aalders T, Oosterwijk E. Identification of potential bladder progenitor cells in the trigone. Dev Biol. 2014;393:84-92 pubmed publisher
Conley S, Al Ubaidi M, Han Z, Naash M. Rim formation is not a prerequisite for distribution of cone photoreceptor outer segment proteins. FASEB J. 2014;28:3468-79 pubmed publisher
Flaht Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska Steifer E, Madej M, et al. Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec (Hoboken). 2014;297:1115-30 pubmed publisher
Lua I, James D, Wang J, WANG K, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014;60:311-22 pubmed publisher
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, et al. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS ONE. 2013;8:e75222 pubmed publisher
Adorno M, Sikandar S, Mitra S, Kuo A, Nicolis Di Robilant B, Haro Acosta V, et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013;501:380-4 pubmed publisher
Lesko M, Driskell R, Kretzschmar K, Goldie S, Watt F. Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013;382:15-26 pubmed publisher
Tasso R, Ulivi V, Reverberi D, Lo Sicco C, Descalzi F, Cancedda R. In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche. Stem Cells Dev. 2013;22:3178-91 pubmed publisher
Krelin Y, Berkovich L, Amit M, Gil Z. Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model. PLoS ONE. 2013;8:e62124 pubmed publisher
Dukic Stefanovic S, Walther J, Wosch S, Zimmermann G, Wiedemann P, Alexander H, et al. Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions. PLoS ONE. 2012;7:e52567 pubmed publisher
Morrison B, Steel J, Morris J. Sphere culture of murine lung cancer cell lines are enriched with cancer initiating cells. PLoS ONE. 2012;7:e49752 pubmed publisher
Peng X, Liu T, Wang Y, Yan Q, Jin H, Li L, et al. Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells. J Transl Med. 2012;10:196 pubmed publisher
Agrawal V, Siu B, Chao H, Hirschi K, Raborn E, Johnson S, et al. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012;18:1454-63 pubmed publisher
Alfaro Cervello C, Soriano Navarro M, Mirzadeh Z, Alvarez Buylla A, Garcia Verdugo J. Biciliated ependymal cell proliferation contributes to spinal cord growth. J Comp Neurol. 2012;520:3528-52 pubmed publisher
Morimoto H, Lee J, Tanaka T, Ishii K, Toyokuni S, Kanatsu Shinohara M, et al. In vitro transformation of mouse testis cells by oncogene transfection. Biol Reprod. 2012;86:148, 1-11 pubmed publisher
Stoll E, Habibi B, Mikheev A, Lasiene J, Massey S, Swanson K, et al. Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone. Stem Cells. 2011;29:2005-17 pubmed publisher
Kuo T, Chen C, Baron D, Onder T, Loewer S, Almeida S, et al. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol. 2011;13:1214-23 pubmed publisher
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, et al. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011;208:949-60 pubmed publisher
Yang Y, Ahn Y, Gibbons D, Zang Y, Lin W, Thilaganathan N, et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest. 2011;121:1373-85 pubmed publisher
Anderson L, Boulanger C, Smith G, Carmeliet P, Watson C. Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland. Dev Dyn. 2011;240:674-81 pubmed publisher
Aizawa T, Hasegawa K, Ohkumo T, Haga S, Ikeda K, Yoshikawa K. Neural stem cell-like gene expression in a mouse ependymoma cell line transformed by human BK polyomavirus. Cancer Sci. 2011;102:122-9 pubmed publisher
Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 2010;70:10411-21 pubmed publisher
Pfenninger C, Steinhoff C, Hertwig F, Nuber U. Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-term in vitro self-renewal and in vivo gene expression. Glia. 2011;59:68-81 pubmed publisher
Kemper K, Tol M, Medema J. Mouse tissues express multiple splice variants of prominin-1. PLoS ONE. 2010;5:e12325 pubmed publisher
Schniedermann J, Rennecke M, Buttler K, Richter G, Städtler A, Norgall S, et al. Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels. BMC Cell Biol. 2010;11:50 pubmed publisher
Swijnenburg R, Govaert J, van der Bogt K, Pearl J, Huang M, Stein W, et al. Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction. Circ Cardiovasc Imaging. 2010;3:77-85 pubmed publisher
Jacquet B, Salinas Mondragon R, Liang H, Therit B, Buie J, Dykstra M, et al. FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development. 2009;136:4021-31 pubmed publisher
Burger P, Gupta R, Xiong X, ONTIVEROS C, Salm S, Moscatelli D, et al. High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells. 2009;27:2220-8 pubmed publisher
Sun Y, Kong W, Falk A, Hu J, Zhou L, Pollard S, et al. CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS ONE. 2009;4:e5498 pubmed publisher
Snippert H, van Es J, van den Born M, Begthel H, Stange D, Barker N, et al. Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 2009;136:2187-2194.e1 pubmed publisher
Santisteban M, Reiman J, Asiedu M, Behrens M, Nassar A, Kalli K, et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 2009;69:2887-95 pubmed publisher
Zacchigna S, Oh H, Wilsch Bräuninger M, Missol Kolka E, Jászai J, Jansen S, et al. Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci. 2009;29:2297-308 pubmed publisher
Zhu L, Gibson P, Currle D, Tong Y, Richardson R, Bayazitov I, et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009;457:603-7 pubmed publisher
Maaser K, Borlak J. A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. Br J Cancer. 2008;99:1635-43 pubmed publisher
Mirzadeh Z, Merkle F, Soriano Navarro M, Garcia Verdugo J, Alvarez Buylla A. Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell. 2008;3:265-78 pubmed publisher
Meletis K, Barnabe Heider F, Carlen M, Evergren E, Tomilin N, Shupliakov O, et al. Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol. 2008;6:e182 pubmed publisher
Shmelkov S, Butler J, Hooper A, Hormigo A, Kushner J, Milde T, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008;118:2111-20 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
Pfenninger C, Roschupkina T, Hertwig F, Kottwitz D, Englund E, Bengzon J, et al. CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res. 2007;67:5727-36 pubmed
Sugiyama T, Rodriguez R, McLean G, Kim S. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A. 2007;104:175-80 pubmed
Ito Y, Hamazaki T, Ohnuma K, Tamaki K, Asashima M, Okochi H. Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133. J Invest Dermatol. 2007;127:1052-60 pubmed
Lamerato Kozicki A, Helm K, Jubala C, Cutter G, Modiano J. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol. 2006;34:870-8 pubmed
Lee A, Kessler J, Read T, Kaiser C, Corbeil D, Huttner W, et al. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005;8:723-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), eBioscience
Catalog # :
14-1331-80
Quantity :
25 µg
Price :
US 114.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Canine, Mouse
Applications :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Canine, Mouse
Clone :
13A4
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The CD133 (AC133) antigen is a 97 kDa glycoprotein, with 5 transmembrane domains, that shows up as a 120 kDa band on protein gels due to glycosylation. CD133 is a cell surface marker expressed by immature hematopoietic stem cells but not mature blood cells. In addition to hematopoietic stem and progenitor cells, CD133 has been found to be a marker for other stem and progenitor cells including neural and embryonic stem cells. CD133 has been shown to be expressed in cancers, including some leukemias and brain tumors, that may be derived from stem cells. Low level expression could also be detected in the kidney, pancreas, placenta, and fetal liver. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of the CD133 gene is also associated with several types of cancer. CD133 is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner, and multiple transcript variants encoding different isoforms have been found.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
4932416E19Rik; AC133; Antigen AC133; antigen AC133 homolog; antigen CD133; CD107b; CD133; CORD12; fudenine; hematopoietic stem cell antigen; hProminin; Lamp II; Lamp2; LAMP-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-96; LGP-B; Mac3; MCDR2; MSTP061; Prom; PROM1; Prom-1; prominin 1; prominin 1.s1; Prominin1; prominin-1; prominin-1.s2; prominin-like 1; prominin-like protein 1; PROML1; RP41; STGD4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA