CD124 Monoclonal Antibody (X2/45-12), eBioscience | Invitrogen 14-1249-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD124 Monoclonal Antibody (X2/45-12), eBioscience

catalog :

14-1249-82

quantity :

100 ug

price :

US 259.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

X2/45-12

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry

citations: 6

Reference
Van Dyken S, Locksley R. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013;31:317-43 pubmed publisher
Khodoun M, Lewis C, Lewis C, Yang J, Orekov T, Potter C, et al. Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses. J Immunol. 2007;179:6429-38 pubmed
Vega F, Coombes K, Thomazy V, Patel K, Lang W, Jones D. Tissue-specific function of lymph node fibroblastic reticulum cells. Pathobiology. 2006;73:71-81 pubmed
Andrews A, Holloway J, Holgate S, Davies D. IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. J Immunol. 2006;176:7456-61 pubmed
Wäldele K, Schneider G, Ruckes T, Grassmann R. Interleukin-13 overexpression by tax transactivation: a potential autocrine stimulus in human T-cell leukemia virus-infected lymphocytes. J Virol. 2004;78:6081-90 pubmed
Tony H, Shen B, Reusch P, Sebald W. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur J Biochem. 1994;225:659-65 pubmed

product information

Product Type :

Antibody

Product Name :

CD124 Monoclonal Antibody (X2/45-12), eBioscience

Catalog # :

14-1249-82

Quantity :

100 ug

Price :

US 259.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunocytochemistry: 1:100, Western Blot: Assay-Dependent

Species :

Human

Clone :

X2/45-12

Isotype :

IgG1, kappa

Storage :

4 C

Description :

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunocytochemistry: 1:100, Western Blot: Assay-Dependent

Aliases :

582J2.1; CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; Il4r; IL4R nirs variant 1; IL-4R subunit alpha; IL4RA; IL-4RA; IL-4R-alpha; interleukin 4 receptor; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble interleukin-4 receptor subunit alpha