This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), eBioscience
catalog :
14-1079-95
quantity :
10 mg
price :
US 3685.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
eBioH4A3
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 37
Reference
Zhang Y, Luo F, Dong K. Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncol Lett. 2023;26:297 pubmed publisher
Ding L, Chen X, Zhang W, Dai X, Guo H, Pan X, et al. Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling. J Clin Invest. 2023;133: pubmed publisher
Molero Valenzuela A, Fontova P, Alonso Carrillo D, Carreira Barral I, Torres A, Garc xed a Valverde M, et al. A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer. Cancers (Basel). 2022;14: pubmed publisher
Xiong X, Hasani S, Young L, Rivas D, Skaggs A, Martinez R, et al. Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer. Cell Death Differ. 2022;: pubmed publisher
von Schoenfeld A, Bronsert P, Poc M, Fuller A, Filby A, Kraft S, et al. Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol. Int J Mol Sci. 2021;23: pubmed publisher
Betriu N, Andreeva A, Semino C. Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel). 2021;13: pubmed publisher
Biadglegne F, Rademacher P, De Sulbaran Y, K xf6 nig B, Rodloff A, Zedler U, et al. Exosomes in serum‑free cultures of THP‑1 macrophages infected with Mycobacterium tuberculosis. Mol Med Rep. 2021;24: pubmed publisher
Silva J, Qi X, Grant M, Boulton M. Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells. Sci Rep. 2021;11:17400 pubmed publisher
Ressnerova A, Novotný F, Michalkova H, Pumera M, Adam V, Heger Z. Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots. ACS Nano. 2021;15:12899-12910 pubmed publisher
Tokarchuk I, Janser F, Schläfli A, Pinto M, Humbert M, Niklaus N, et al. Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability. Biochem Biophys Res Commun. 2021;569:47-53 pubmed publisher
Zheng G, Guo Z, Li W, Xi W, Zuo B, Zhang R, et al. Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab. Signal Transduct Target Ther. 2021;6:236 pubmed publisher
Cejas R, Tamaño Blanco M, Blanco J. Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21). Sci Rep. 2021;11:10981 pubmed publisher
Humbert M, Seiler K, Mosimann S, Rentsch V, Sharma K, Pandey A, et al. Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy. Cell Death Differ. 2021;28:2465-2481 pubmed publisher
Hope J, Bersi M, Dombroski J, Clinch A, Pereles R, Merryman W, et al. Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death. J Cell Sci. 2021;134: pubmed publisher
Skubalova Z, Rex S, Sukupova M, Zahalka M, Skladal P, Pribyl J, et al. Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System. Int J Nanomedicine. 2021;16:1-14 pubmed publisher
Menasche B, Davis E, Wang S, Ouyang Y, Li S, Yu H, et al. PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Sci Adv. 2020;6: pubmed publisher
Sant S, Quiñones Parra S, Koutsakos M, Grant E, Loudovaris T, Mannering S, et al. HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. PLoS Pathog. 2020;16:e1008714 pubmed publisher
Stunnenberg M, van Pul L, Sprokholt J, van Dort K, Gringhuis S, Geijtenbeek T, et al. MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals. Viruses. 2020;12: pubmed publisher
Arbore G, West E, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun. 2018;9:4186 pubmed publisher
Sponaas A, Yang R, Rustad E, Standal T, Thoresen A, Dao Vo C, et al. PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients. Oncotarget. 2018;9:32024-32035 pubmed publisher
Li Y, Hermanson D, Moriarity B, Kaufman D. Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity. Cell Stem Cell. 2018;23:181-192.e5 pubmed publisher
Kratchmarov R, Magun A, Reiner S. TCF1 expression marks self-renewing human CD8+ T cells. Blood Adv. 2018;2:1685-1690 pubmed publisher
Law C, Siu C, Fan K, Lai W, Au K, Lau Y, et al. Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons. Biochem Biophys Rep. 2016;5:335-345 pubmed publisher
Sibilano R, Gaudenzio N, DeGorter M, Reber L, Hernandez J, Starkl P, et al. A TNFRSF14-Fc?RI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016;7:13696 pubmed publisher
Kim S, Roy S, Chen B, Nguyen T, McMonigle R, McCracken A, et al. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 2016;126:4088-4102 pubmed publisher
Wahid R, Fresnay S, Levine M, Sztein M. Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a. Clin Immunol. 2016;173:87-95 pubmed publisher
Tan K, Ho M, Cho H, Yu J, Hung J, Yu A. Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. Cell Death Dis. 2016;7:e2347 pubmed publisher
Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, Iwayama N, et al. Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques. PLoS ONE. 2016;11:e0157535 pubmed publisher
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Singh N, Kulikovskaya I, Barrett D, Binder Scholl G, Jakobsen B, Martinez D, et al. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Oncoimmunology. 2016;5:e1040216 pubmed
Dieckmann N, Hackmann Y, Aricò M, Griffiths G. Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes. Traffic. 2015;16:1330-41 pubmed publisher
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Barlan A, Danthi P, Wiethoff C. Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome. Virology. 2011;412:306-14 pubmed publisher
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Huynh C, Andrews N. The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 2005;6:843-7 pubmed
product information
Product Type :
Antibody
Product Name :
CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), eBioscience
Catalog # :
14-1079-95
Quantity :
10 mg
Price :
US 3685.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.5 ug/test, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 0.5 ug/test
Species :
Human
Clone :
eBioH4A3
Isotype :
IgG1, kappa
Storage :
4 C
Description :
LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 0.5 ug/test
Aliases :
120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; LAMP1; LAMP-1; LAMPA; LGP120; LGP-120; LGPA; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA