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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), eBioscience
catalog :
14-1071-81
quantity :
50 µg
price :
US 101.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eBio1D4B (1D4B)
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 92
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; fig 4j
Wang H, Do D, Liu J, Wang B, Qu J, Ke X, et al. Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2018;141:586-600.e6 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 4a
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Shifrin N, Kissiov D, Ardolino M, Joncker N, Raulet D. Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness. J Immunol. 2016;197:4127-4136 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
  • flow cytometry; mouse; fig 3
Moretto M, Khan I. IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. J Immunol. 2016;196:375-84 pubmed publisher
  • flow cytometry; mouse; fig 6
Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
  • flow cytometry; mouse; fig s3
Pereira I, Vilar Pereira G, Moreira O, Ramos I, Gibaldi D, Britto C, et al. Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response. PLoS Negl Trop Dis. 2015;9:e0003659 pubmed publisher
  • flow cytometry; mouse; 1:1000; fig 2g
Burton O, Logsdon S, Zhou J, Medina Tamayo J, Abdel Gadir A, Noval Rivas M, et al. Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. J Allergy Clin Immunol. 2014;134:1310-1317.e6 pubmed publisher
  • flow cytometry; mouse
Lee J, Walsh M, Hoehn K, James D, Wherry E, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol. 2014;192:3190-9 pubmed publisher
  • blocking or activating experiments; mouse
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
Zhong D, Wang R, Zhang H, Wang M, Zhang X, Chen H. Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity. Nat Commun. 2023;14:3997 pubmed publisher
Ta A, Ricci Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, et al. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023;14:2035 pubmed publisher
Zhu D, Huang Y, Guo S, Li N, Yang X, Sui A, et al. AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting Nav 1.6-Mediated Astrocyte Autophagy. Adv Sci (Weinh). 2023;10:e2205862 pubmed publisher
Ren J, Han X, Lohner H, Hoyle R, Li J, Liang S, et al. P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer. Cancer Immunol Res. 2023;11:290-305 pubmed publisher
Wu Y, Shao W, Todd T, Tong J, Yue M, Koga S, et al. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD. Cell Rep. 2021;36:109581 pubmed publisher
Pan P, Zhu J, Rizvi A, Zhu X, Tanaka H, Dreyfus C. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. J Biol Chem. 2021;297:100873 pubmed publisher
Wang X, Shi J, Li Z, Li L, Zhang R, Bai Y, et al. An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling. Front Pharmacol. 2021;12:673818 pubmed publisher
Benjamin S, Hawley K, Vera Licona P, La Vake C, Cervantes J, Ruan Y, et al. Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation. BMC Immunol. 2021;22:32 pubmed publisher
Wang X, Li Z, Bai Y, Zhang R, Meng R, Chen F, et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis. 2021;12:402 pubmed publisher
LeBlond N, Nunes J, Smith T, O Dwyer C, Robichaud S, Gadde S, et al. Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis. Int J Mol Sci. 2020;21: pubmed publisher
Leventhal D, Sokolovska A, Li N, Plescia C, Kolodziej S, Gallant C, et al. Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nat Commun. 2020;11:2739 pubmed publisher
Cham L, Torrez Dulgeroff L, Tal M, Adomati T, Li F, Bhat H, et al. Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection. Cell Rep. 2020;31:107494 pubmed publisher
Salhab A, Amer J, Yinying L, Safadi R. 25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor. BMC Gastroenterol. 2020;20:102 pubmed publisher
Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen C, Mashek D. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy. 2020;:1-16 pubmed publisher
Stone S, Wu S, Nave K, Lin W. The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP. JCI Insight. 2020;5: pubmed publisher
Charpentier J, Chen D, Lapinski P, Turner J, Grigorova I, Swanson J, et al. Macropinocytosis drives T cell growth by sustaining the activation of mTORC1. Nat Commun. 2020;11:180 pubmed publisher
Železnjak J, Lisnic V, Popovic B, Lisnić B, Babic M, Halenius A, et al. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. J Exp Med. 2019;: pubmed publisher
Yshii L, Pignolet B, Mauré E, Pierau M, Brunner Weinzierl M, Hartley O, et al. IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration. JCI Insight. 2019;4: pubmed publisher
Salerno F, Guislain A, Freen van Heeren J, Nicolet B, Young H, Wolkers M. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells. Oncoimmunology. 2019;8:e1532762 pubmed publisher
De Zuani M, Paolicelli G, Zelante T, Renga G, Romani L, Arzese A, et al. Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus. Front Immunol. 2018;9:2829 pubmed publisher
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed publisher
Danahy D, Anthony S, Jensen I, Hartwig S, Shan Q, Xue H, et al. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog. 2017;13:e1006569 pubmed publisher
Cheadle E, Lipowska Bhalla G, Dovedi S, Fagnano E, Klein C, Honeychurch J, et al. A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells. Leukemia. 2017;31:1611-1621 pubmed publisher
Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
Qi X, Man S, Malireddi R, Karki R, Lupfer C, Gurung P, et al. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016;213:2081-97 pubmed publisher
Frenkel D, Zhang F, Guirnalda P, Haynes C, Bockstal V, Radwanska M, et al. Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells. PLoS Pathog. 2016;12:e1005733 pubmed publisher
Ahn B, Kohanbash G, Ohkuri T, Kosaka A, Chen X, Ikeura M, et al. Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas. Oncoimmunology. 2015;4:e1047581 pubmed
Pascutti M, Geerman S, Slot E, van Gisbergen K, Boon L, Arens R, et al. Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection. PLoS Pathog. 2015;11:e1004675 pubmed publisher
Rogers G, Suzuki M, Zolotukhin I, Markusic D, MOREL L, Lee B, et al. Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer. J Innate Immun. 2015;7:302-14 pubmed publisher
Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015;194:125-133 pubmed publisher
Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, et al. Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock. PLoS ONE. 2014;9:e110585 pubmed publisher
Urban S, Welsh R. Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses. PLoS Pathog. 2014;10:e1004357 pubmed publisher
Goulding J, Abboud G, Tahiliani V, Desai P, Hutchinson T, Salek Ardakani S. CD8 T cells use IFN-? to protect against the lethal effects of a respiratory poxvirus infection. J Immunol. 2014;192:5415-25 pubmed publisher
Seto S, Tsujimura K, Horii T, Koide Y. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PLoS ONE. 2013;8:e86017 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Fulton R, Weiss K, Pewe L, Harty J, Varga S. Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection. J Virol. 2013;87:12694-700 pubmed publisher
Prabhu N, Ho A, Wong K, Hutchinson P, Chua Y, Kandasamy M, et al. Gamma interferon regulates contraction of the influenza virus-specific CD8 T cell response and limits the size of the memory population. J Virol. 2013;87:12510-22 pubmed publisher
Ding L, Chen T, Wang X, Zhou L, Shi A, Ning Q. CD69+NK cells contribute to the murine hepatitis virus strain 3-induced murine hepatitis. J Huazhong Univ Sci Technolog Med Sci. 2013;33:505-510 pubmed publisher
Baldwin S, Ching L, Pine S, Moutaftsi M, Lucas E, Vallur A, et al. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. J Immunol. 2013;191:2514-2525 pubmed publisher
Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, et al. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood. 2013;121:2943-51 pubmed publisher
Woolard M, Barrigan L, Fuller J, Buntzman A, Bryan J, Manoil C, et al. Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages. Front Microbiol. 2013;4:16 pubmed publisher
Leonhardt F, Grundmann S, Behe M, Bluhm F, Dumont R, Braun F, et al. Inflammatory neovascularization during graft-versus-host disease is regulated by ?v integrin and miR-100. Blood. 2013;121:3307-18 pubmed publisher
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, et al. Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity. J Invest Dermatol. 2013;133:702-711 pubmed publisher
Sepulveda F, Debeurme F, Menasche G, Kurowska M, Côte M, Pachlopnik Schmid J, et al. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013;121:595-603 pubmed publisher
D Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans Borgmeyer I, et al. Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol. 2013;43:194-208 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
Kawano Y, Ouchida R, Wang J, Yoshikawa S, Yamamoto M, Kitamura D, et al. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5. Mol Cell Biol. 2012;32:4462-71 pubmed publisher
Thomas M, Abdul Wajid S, Panduro M, Babiarz J, Rajaram M, Woodruff P, et al. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012;120:130-42 pubmed publisher
Semmrich M, Plantinga M, Svensson Frej M, Uronen Hansson H, Gustafsson T, Mowat A, et al. Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses. Mucosal Immunol. 2012;5:150-60 pubmed publisher
Huijbers I, Soudja S, Uyttenhove C, Buferne M, Inderberg Suso E, Colau D, et al. Minimal tolerance to a tumor antigen encoded by a cancer-germline gene. J Immunol. 2012;188:111-21 pubmed publisher
Rossi L, Avila D, Spallanzani R, Ziblat A, Fuertes M, Lapyckyj L, et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J Leukoc Biol. 2012;91:321-31 pubmed publisher
Ruzo A, Garcia M, Ribera A, Villacampa P, Haurigot V, Marcó S, et al. Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice. Mol Ther. 2012;20:254-66 pubmed publisher
Jessen B, Maul Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, et al. Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood. 2011;118:4620-9 pubmed publisher
Toma C, Okura N, Takayama C, Suzuki T. Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages. Cell Microbiol. 2011;13:1783-92 pubmed publisher
Lee G, Liou Y, Wang S, Ko K, Jiang S, Liao N. Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol. 2011;187:1212-21 pubmed publisher
Hoves S, Sutton V, Haynes N, Hawkins E, Fernández Ruiz D, Baschuk N, et al. A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol. 2011;187:1166-75 pubmed publisher
André M, Sigurdardottir D, Kuttruff S, Pömmerl B, Handgretinger R, Rammensee H, et al. Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction. Int J Cancer. 2012;131:1601-10 pubmed publisher
Sillé F, Martin C, Jayaraman P, Rothchild A, Fortune S, Besra G, et al. Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infect Immun. 2011;79:3053-63 pubmed publisher
Uchida Y, Kawai K, Ibusuki A, Kanekura T. Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells. J Immunol. 2011;186:6945-54 pubmed publisher
Fujita M, Kohanbash G, Fellows Mayle W, Hamilton R, Komohara Y, Decker S, et al. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res. 2011;71:2664-74 pubmed publisher
Gibbert K, Dietze K, Zelinskyy G, Lang K, Barchet W, Kirschning C, et al. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol. 2010;185:6179-89 pubmed publisher
Elliott J, Wahle J, Yokoyama W. MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment. J Exp Med. 2010;207:2073-9 pubmed publisher
Atkinson B, Jasuja R, Chen V, Nandivada P, Furie B, Furie B. Laser-induced endothelial cell activation supports fibrin formation. Blood. 2010;116:4675-83 pubmed publisher
Wang Y, Gorvel J, Chu Y, Wu J, Lei H. Helicobacter pylori impairs murine dendritic cell responses to infection. PLoS ONE. 2010;5:e10844 pubmed publisher
Heinsbroek S, Kamen L, Taylor P, Brown G, Swanson J, Gordon S. Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages. J Innate Immun. 2009;1:244-53 pubmed publisher
Motz G, Eppert B, Wortham B, Amos Kroohs R, Flury J, Wesselkamper S, et al. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2010;184:4460-9 pubmed publisher
Mohan J, Levisetti M, Calderon B, Herzog J, Petzold S, Unanue E. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol. 2010;11:350-4 pubmed publisher
COGHILL J, Carlson M, Panoskaltsis Mortari A, West M, Burgents J, Blazar B, et al. Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells. Blood. 2010;115:4914-22 pubmed publisher
Xie Y, Akpinarli A, Maris C, Hipkiss E, Lane M, Kwon E, et al. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med. 2010;207:651-67 pubmed publisher
White D, Keppel C, Schneider S, Reese T, Coder J, Payton J, et al. Latent herpesvirus infection arms NK cells. Blood. 2010;115:4377-83 pubmed publisher
Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, et al. Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression. Cancer Sci. 2009;100:1317-25 pubmed publisher
Whang M, Guerra N, Raulet D. Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin. J Immunol. 2009;182:4557-64 pubmed publisher
Tomihari M, Hwang S, Chung J, Cruz P, Ariizumi K. Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion. Exp Dermatol. 2009;18:586-95 pubmed publisher
Imai N, Ikeda H, Tawara I, Shiku H. Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells. Eur J Immunol. 2009;39:241-53 pubmed publisher
Halle A, Hornung V, Petzold G, Stewart C, Monks B, Reinheckel T, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008;9:857-65 pubmed publisher
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Hovav A, Panas M, Rahman S, Sircar P, Gillard G, Cayabyab M, et al. Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007;179:6725-33 pubmed
Hovav A, Cayabyab M, Panas M, Santra S, Greenland J, Geiben R, et al. Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. J Virol. 2007;81:74-83 pubmed
Betts M, Koup R. Detection of T-cell degranulation: CD107a and b. Methods Cell Biol. 2004;75:497-512 pubmed
Wolint P, Betts M, Koup R, Oxenius A. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J Exp Med. 2004;199:925-36 pubmed
Gough N, Zweifel M, Martinez Augustin O, Aguilar R, Bonifacino J, Fambrough D. Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals. J Cell Sci. 1999;112 ( Pt 23):4257-69 pubmed
Rohrer J, Schweizer A, Russell D, Kornfeld S. The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. J Cell Biol. 1996;132:565-76 pubmed
product information
Product Type :
Antibody
Product Name :
CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), eBioscience
Catalog # :
14-1071-81
Quantity :
50 µg
Price :
US 101.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Mouse
Clone :
eBio1D4B (1D4B)
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; LAMP1; LAMP-1; LAMPA; LGP120; LGP-120; LGPA; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA