CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), eBioscience | Invitrogen 14-1038-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), eBioscience

catalog :

14-1038-82

quantity :

100 µg

price :

US 137.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

B-Ly7

reactivity :

African green monkey, human, rhesus macaque

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, mass cytometry

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1e	Bujko A, Atlasy N, Landsverk O, Richter L, Yaqub S, Horneland R, et al. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2018;215:441-458 pubmed publisher
mass cytometry; human; loading ...; fig 2a	Chew V, Lai L, Pan L, Lim C, Li J, Ong R, et al. Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Proc Natl Acad Sci U S A. 2017;114:E5900-E5909 pubmed publisher
flow cytometry; human; loading ...; tbl 1	Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed publisher
flow cytometry; human; fig 1f	Boddupalli C, Nair S, Gray S, Nowyhed H, Verma R, Gibson J, et al. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016;126:3905-3916 pubmed publisher
flow cytometry; human; 1:100; fig 1	Marafini I, Monteleone I, Di Fusco D, Sedda S, Cupi M, Fina D, et al. Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells. PLoS ONE. 2016;11:e0155103 pubmed publisher
flow cytometry; human; 9 ug/ml	Leong M, Newell E. Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry. Methods Mol Biol. 2015;1346:115-31 pubmed publisher
flow cytometry; African green monkey; loading ...; fig s1d	Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
flow cytometry; rhesus macaque	Klatt N, Estes J, Sun X, Ortiz A, Barber J, Harris L, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57 pubmed publisher
	Duhen R, Ballesteros Merino C, Frye A, Tran E, Rajamanickam V, Chang S, et al. Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. Nat Commun. 2021;12:1047 pubmed publisher
	Duhen T, Duhen R, Montler R, Moses J, Moudgil T, de Miranda N, et al. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nat Commun. 2018;9:2724 pubmed publisher
	Fenton T, Kelly A, Shuttleworth E, Smedley C, Atakilit A, Powrie F, et al. Inflammatory cues enhance TGFÎ² activation by distinct subsets of human intestinal dendritic cells via integrin Î±vÎ²8. Mucosal Immunol. 2017;10:624-634 pubmed publisher
	Jozwik A, Habibi M, Paras A, Zhu J, Guvenel A, Dhariwal J, et al. RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection. Nat Commun. 2015;6:10224 pubmed publisher
	Pichyangkul S, Yongvanitchit K, Limsalakpetch A, Kum Arb U, Im Erbsin R, Boonnak K, et al. Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection. J Immunol. 2015;195:4378-86 pubmed publisher
	Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-? production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Ann Rheum Dis. 2014;73:1223-31 pubmed publisher
	Poulin L, Reyal Y, Uronen Hansson H, Schraml B, Sancho D, Murphy K, et al. DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood. 2012;119:6052-62 pubmed publisher
	Lechner M, Megiel C, Russell S, Bingham B, Arger N, Woo T, et al. Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. J Transl Med. 2011;9:90 pubmed publisher
	Beitnes A, Raki M, Lundin K, Jahnsen J, Sollid L, Jahnsen F. Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion. Scand J Immunol. 2011;74:186-94 pubmed publisher
	Poulin L, Salio M, Griessinger E, Anjos Afonso F, Craciun L, Chen J, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010;207:1261-71 pubmed publisher
	Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
	De Harven E, Soligo D, Christensen H. Immunogold labeling for the diagnosis of leukemia by transmission and scanning electron microscopy. Scanning Microsc. 1995;9:1191-199; discussion 1199-1201 pubmed
	De Harven E, Christensen H, Poppema S, Scott J. Immunogold labelling of leukemic hairy cells with the B-ly7 monoclonal antibody: an SEM and TEM study. Microsc Res Tech. 1994;28:356-67 pubmed
	Thaler J, Dietze O, Faber V, Greil R, Gastl G, Denz H, et al. Monoclonal antibody B-ly7: a sensitive marker for detection of minimal residual disease in hairy cell leukemia. Leukemia. 1990;4:170-6 pubmed
	Schwarting R, Dienemann D, Kruschwitz M, Fritsche G, Stein H. Specificities of monoclonal antibodies B-ly7 and HML-1 are identical. Blood. 1990;75:320-1 pubmed
	Visser L, Dabbagh L, Poppema S. Reactivity of monoclonal antibody B-ly7 with a subset of activated T cells and T-cell lymphomas. Hematol Pathol. 1992;6:37-42 pubmed

product information

Product Type :

Antibody

Product Name :

CD103 (Integrin alpha E) Monoclonal Antibody (B-Ly7), eBioscience

Catalog # :

14-1038-82

Quantity :

100 µg

Price :

US 137.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Human

Clone :

B-Ly7

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

A530055J10; alpha-E1; alpha-M290; aM290; antigen CD103; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; DC; DCs; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha E; integrin alpha E, epithelial-associated; integrin alpha E1, epithelial-associated; integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; Integrin alpha-IEL; integrin subunit alpha E; integrin, alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); integrin, alpha E, epithelial-associated; Intregrin alpha E2; Itgae; MGC141996; Mucosal lymphocyte 1 antigen

more info or order :

Invitrogen product webpage