Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience | Invitrogen 14-1028-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience

catalog :

14-1028-82

quantity :

100 µg

price :

US 279.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Bcl-2/100

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:500; fig 1, 2, 3	Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed publisher
	Yang J, Guo W, Wang J, Yang X, Zhang Z, Zhao Z. T-2 Toxin-Induced Oxidative Stress Leads to Imbalance of Mitochondrial Fission and Fusion to Activate Cellular Apoptosis in the Human Liver 7702 Cell Line. Toxins (Basel). 2020;12: pubmed publisher
	Saunders I, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019;19:98 pubmed publisher
	Li Q, Tanaka Y, Miwa N. Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of normal human esophageal epitheliocytes. Med Gas Res. 2018;8:57-63 pubmed publisher
	Li Q, Tanaka Y, Miwa N. Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro. Med Gas Res. 2017;7:76-85 pubmed publisher
	Cummins N, Sainski Nguyen A, Natesampillai S, Aboulnasr F, Kaufmann S, Badley A. Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition. J Virol. 2017;91: pubmed publisher
	Zhang S, Li Y, He X, Dong S, Huang Y, Li X, et al. Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo. Int J Nanomedicine. 2014;9:1931-46 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience

Catalog # :

14-1028-82

Quantity :

100 µg

Price :

US 279.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry: Assay-Dependent, Western Blot: 2 µg/mL

Species :

Human

Clone :

Bcl-2/100

Isotype :

IgG1, kappa

Storage :

4° C

Description :

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay-Dependent, Western Blot: 2 µg/mL

Aliases :

apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50

more info or order :

Invitrogen product webpage